Catalysis at the Homogeneous-Heterogeneous Chemistry Interface

1 Results Significant progress has been made in recent years in developing efficient, atom economical catalytic reactions of potential applicability to the pharmaceutical, petrochemical, and commodity chemical business sectors. In some cases, homogeneous catalytic processes offer advantages, but in others the use of heterogenized homogeneous catalysis provides a competitive advantage concerning recyclability and catalyst recovery. This presentation will consider new approaches to cyclization reactions a...     

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin. These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans.     

Old radiocarbon ages in the southwest Pacific Ocean during the last glacial period and deglaciation

Marine radiocarbon (14C) dates are widely used for dating oceanic events and as tracers of ocean circulation, essential components for understanding ocean-climate interactions. Past ocean ventilation rates have been determined by the difference between radiocarbon ages of deep-water and surface-water reservoirs, but the apparent age of surface waters (currently approximately 400 years in the tropics and approximately 1,200 years in Antarctic waters) might not be constant through time, as has been assumed in radiocarbon chronologies and palaeoclimate studies. Here we present independent estimates of surface-water and deep-water reservoir ages in the New Zealand region since the last glacial period, using volcanic ejecta (tephras) deposited in both marine and terrestrial sediments as stratigraphic markers. Compared to present-day values, surface-reservoir ages from 11,900 14C years ago were twice as large (800 years) and during glacial times were five times as large (2,000 years), contradicting the assumption of constant surface age. Furthermore, the ages of glacial deep-water reservoirs were much older (3,000-5,000 years). The increase in surface-to-deep water age differences in the glacial Southern Ocean suggests that there was decreased ocean ventilation during this period.     

Synthesis of rabbit beta-globin in cultured monkey kidney cells following infection with a SV40 beta-globin recombinant genome.

Rabbit beta-globin complementary DNA (cDNA) has been inserted into SV40 DNA in place of the gene coding for the virus' major capsid protein, VP1. The recombinant genome, SVGT5-RabetaG, multiplies efficiently in CV1 monkey kidney cell cultures and is transcribed to yield cytoplasmic, polyadenylated hybrid mRNAs containing the beta-globin coding sequence. Cells propagating SVGT5-RabetaG produce substantial quantities of rabbit beta-globin polypeptide.     

Correlation between electrophoretic mobility and heavy chain sub-classes of residual IgG from patients with severe hypogammaglobulinaemia

Summary The correlation between the electrophoretic mobility of residual IgG in hypogammaglobulinaemic sera and the distribution of IgG sub-classes was studied. It was found that IgG from sera with raised levels of IgG2 show fast electrophoretic mobility, and sera with very low or absent IgG2 show a slow moving IgG. IgG3 was absent or just detectable in fast moving IgGs, and present in higher titers in some slow IgGs.

---

Résumé La correlation entre la mobilité electrophorétique de l'IgG résiduelle des sérums hypogammaglobulinémiques et la distribution des sous-classes de l'IgG est l'objet de cet étude. Les IgG résiduelles de mobilité rapide ont des titres élevés d'IgG2 et celles de mobilité lente ne présentent que des traces d'IgG2.