全文获取类型
收费全文 | 226篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 3篇 |
教育与普及 | 1篇 |
现状及发展 | 49篇 |
研究方法 | 44篇 |
综合类 | 128篇 |
自然研究 | 2篇 |
出版年
2021年 | 2篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2014年 | 5篇 |
2013年 | 2篇 |
2012年 | 13篇 |
2011年 | 17篇 |
2010年 | 5篇 |
2008年 | 13篇 |
2007年 | 25篇 |
2006年 | 12篇 |
2005年 | 18篇 |
2004年 | 14篇 |
2003年 | 7篇 |
2002年 | 9篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 1篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 5篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 4篇 |
1964年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有227条查询结果,搜索用时 484 毫秒
131.
Shundong Bi Romain Amiot Claire Peyre de Fabrègues Michael Pittman Matthew C.Lamanna Yilun Yu Congyu Yu Tzuruei Yang Shukang Zhang Qi Zhao Xing Xu 《科学通报(英文版)》2021,(9):947-954
Recent studies demonstrate that many avialan features evolved incrementally prior to the origin of the group,but the presence of some of these features,such as ... 相似文献
132.
Molecular coupling of Tsix regulation and pluripotency 总被引:1,自引:0,他引:1
Navarro P Oldfield A Legoupi J Festuccia N Dubois A Attia M Schoorlemmer J Rougeulle C Chambers I Avner P 《Nature》2010,468(7322):457-460
133.
Amole C Ashkezari MD Baquero-Ruiz M Bertsche W Bowe PD Butler E Capra A Cesar CL Charlton M Deller A Donnan PH Eriksson S Fajans J Friesen T Fujiwara MC Gill DR Gutierrez A Hangst JS Hardy WN Hayden ME Humphries AJ Isaac CA Jonsell S Kurchaninov L Little A Madsen N McKenna JT Menary S Napoli SC Nolan P Olchanski K Olin A Pusa P Rasmussen CØ Robicheaux F Sarid E Shields CR Silveira DM Stracka S So C Thompson RI van der Werf DP Wurtele JS 《Nature》2012,483(7390):439-443
The hydrogen atom is one of the most important and influential model systems in modern physics. Attempts to understand its spectrum are inextricably linked to the early history and development of quantum mechanics. The hydrogen atom's stature lies in its simplicity and in the accuracy with which its spectrum can be measured and compared to theory. Today its spectrum remains a valuable tool for determining the values of fundamental constants and for challenging the limits of modern physics, including the validity of quantum electrodynamics and--by comparison with measurements on its antimatter counterpart, antihydrogen--the validity of CPT (charge conjugation, parity and time reversal) symmetry. Here we report spectroscopy of a pure antimatter atom, demonstrating resonant quantum transitions in antihydrogen. We have manipulated the internal spin state of antihydrogen atoms so as to induce magnetic resonance transitions between hyperfine levels of the positronic ground state. We used resonant microwave radiation to flip the spin of the positron in antihydrogen atoms that were magnetically trapped in the ALPHA apparatus. The spin flip causes trapped anti-atoms to be ejected from the trap. We look for evidence of resonant interaction by comparing the survival rate of trapped atoms irradiated with microwaves on-resonance to that of atoms subjected to microwaves that are off-resonance. In one variant of the experiment, we detect 23 atoms that survive in 110 trapping attempts with microwaves off-resonance (0.21 per attempt), and only two atoms that survive in 103 attempts with microwaves on-resonance (0.02 per attempt). We also describe the direct detection of the annihilation of antihydrogen atoms ejected by the microwaves. 相似文献
134.
Cancer immunoediting is a process by which immune cells, particularly lymphocytes of the adaptive immune system, protect the host from the development of cancer and alter tumour progression by driving the outgrowth of tumour cells with decreased sensitivity to immune attack. Carcinogen-induced mouse models of cancer have shown that primary tumour susceptibility is thereby enhanced in immune-compromised mice, whereas the capacity for such tumours to grow after transplantation into wild-type mice is reduced. However, many questions about the process of cancer immunoediting remain unanswered, in part because of the known antigenic complexity and heterogeneity of carcinogen-induced tumours. Here we adapted a genetically engineered, autochthonous mouse model of sarcomagenesis to investigate the process of cancer immunoediting. This system allows us to monitor the onset and growth of immunogenic and non-immunogenic tumours induced in situ that harbour identical genetic and histopathological characteristics. By comparing the development of such tumours in immune-competent mice with their development in mice with broad immunodeficiency or specific antigenic tolerance, we show that recognition of tumour-specific antigens by lymphocytes is critical for immunoediting against sarcomas. Furthermore, primary sarcomas were edited to become less immunogenic through the selective outgrowth of cells that were able to escape T lymphocyte attack. Loss of tumour antigen expression or presentation on major histocompatibility complex I was necessary and sufficient for this immunoediting process to occur. These results highlight the importance of tumour-specific-antigen expression in immune surveillance, and potentially, immunotherapy. 相似文献
135.
An index to assess the health and benefits of the global ocean 总被引:15,自引:0,他引:15
BS Halpern C Longo D Hardy KL McLeod JF Samhouri SK Katona K Kleisner SE Lester J O'Leary M Ranelletti AA Rosenberg C Scarborough ER Selig BD Best DR Brumbaugh FS Chapin LB Crowder KL Daly SC Doney C Elfes MJ Fogarty SD Gaines KI Jacobsen LB Karrer HM Leslie E Neeley D Pauly S Polasky B Ris K St Martin GS Stone UR Sumaila D Zeller 《Nature》2012,488(7413):615-620
The ocean plays a critical role in supporting human well-being, from providing food, livelihoods and recreational opportunities to regulating the global climate. Sustainable management aimed at maintaining the flow of a broad range of benefits from the ocean requires a comprehensive and quantitative method to measure and monitor the health of coupled human–ocean systems. We created an index comprising ten diverse public goals for a healthy coupled human–ocean system and calculated the index for every coastal country. Globally, the overall index score was 60 out of 100 (range 36–86), with developed countries generally performing better than developing countries, but with notable exceptions. Only 5% of countries scored higher than 70, whereas 32% scored lower than 50. The index provides a powerful tool to raise public awareness, direct resource management, improve policy and prioritize scientific research. 相似文献
136.
Mountain beavers cache plants in neat piles above the ground near the entrances to their underground burrows, although the purpose of these hay piles remains controversial. We tested the hypothesis that drying plants in piles above ground may slow decay when the plants are stored underground. Predried plants and undried controls were placed in abandoned burrows. Plants that had been predried retained more green and decayed more slowly than undried controls. This experimental test supports the hypothesis that haying may extend the time during which plants are useful to mountain beavers. 相似文献
137.
Joron M Frezal L Jones RT Chamberlain NL Lee SF Haag CR Whibley A Becuwe M Baxter SW Ferguson L Wilkinson PA Salazar C Davidson C Clark R Quail MA Beasley H Glithero R Lloyd C Sims S Jones MC Rogers J Jiggins CD ffrench-Constant RH 《Nature》2011,477(7363):203-206
Supergenes are tight clusters of loci that facilitate the co-segregation of adaptive variation, providing integrated control of complex adaptive phenotypes. Polymorphic supergenes, in which specific combinations of traits are maintained within a single population, were first described for 'pin' and 'thrum' floral types in Primula and Fagopyrum, but classic examples are also found in insect mimicry and snail morphology. Understanding the evolutionary mechanisms that generate these co-adapted gene sets, as well as the mode of limiting the production of unfit recombinant forms, remains a substantial challenge. Here we show that individual wing-pattern morphs in the polymorphic mimetic butterfly Heliconius numata are associated with different genomic rearrangements at the supergene locus P. These rearrangements tighten the genetic linkage between at least two colour-pattern loci that are known to recombine in closely related species, with complete suppression of recombination being observed in experimental crosses across a 400-kilobase interval containing at least 18 genes. In natural populations, notable patterns of linkage disequilibrium (LD) are observed across the entire P region. The resulting divergent haplotype clades and inversion breakpoints are found in complete association with wing-pattern morphs. Our results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the P locus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. These findings highlight how genomic rearrangements can have a central role in the coexistence of adaptive phenotypes involving several genes acting in concert, by locally limiting recombination and gene flow. 相似文献
138.
The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla 总被引:20,自引:0,他引:20
Jaillon O Aury JM Noel B Policriti A Clepet C Casagrande A Choisne N Aubourg S Vitulo N Jubin C Vezzi A Legeai F Hugueney P Dasilva C Horner D Mica E Jublot D Poulain J Bruyère C Billault A Segurens B Gouyvenoux M Ugarte E Cattonaro F Anthouard V Vico V Del Fabbro C Alaux M Di Gaspero G Dumas V Felice N Paillard S Juman I Moroldo M Scalabrin S Canaguier A Le Clainche I Malacrida G Durand E Pesole G Laucou V Chatelet P Merdinoglu D Delledonne M Pezzotti M Lecharny A Scarpelli C Artiguenave F 《Nature》2007,449(7161):463-467
The analysis of the first plant genomes provided unexpected evidence for genome duplication events in species that had previously been considered as true diploids on the basis of their genetics. These polyploidization events may have had important consequences in plant evolution, in particular for species radiation and adaptation and for the modulation of functional capacities. Here we report a high-quality draft of the genome sequence of grapevine (Vitis vinifera) obtained from a highly homozygous genotype. The draft sequence of the grapevine genome is the fourth one produced so far for flowering plants, the second for a woody species and the first for a fruit crop (cultivated for both fruit and beverage). Grapevine was selected because of its important place in the cultural heritage of humanity beginning during the Neolithic period. Several large expansions of gene families with roles in aromatic features are observed. The grapevine genome has not undergone recent genome duplication, thus enabling the discovery of ancestral traits and features of the genetic organization of flowering plants. This analysis reveals the contribution of three ancestral genomes to the grapevine haploid content. This ancestral arrangement is common to many dicotyledonous plants but is absent from the genome of rice, which is a monocotyledon. Furthermore, we explain the chronology of previously described whole-genome duplication events in the evolution of flowering plants. 相似文献
139.
The human microbiome project 总被引:3,自引:0,他引:3
A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease. 相似文献
140.
LeBoeuf D Doiron-Leyraud N Levallois J Daou R Bonnemaison JB Hussey NE Balicas L Ramshaw BJ Liang R Bonn DA Hardy WN Adachi S Proust C Taillefer L 《Nature》2007,450(7169):533-536
High-temperature superconductivity in copper oxides occurs when the materials are chemically tuned to have a carrier concentration intermediate between their metallic state at high doping and their insulating state at zero doping. The underlying evolution of the electron system in the absence of superconductivity is still unclear, and a question of central importance is whether it involves any intermediate phase with broken symmetry. The Fermi surface of the electronic states in the underdoped 'YBCO' materials YBa2Cu3O(y) and YBa2Cu4O8 was recently shown to include small pockets, in contrast with the large cylinder that characterizes the overdoped regime, pointing to a topological change in the Fermi surface. Here we report the observation of a negative Hall resistance in the magnetic-field-induced normal state of YBa2Cu3O(y) and YBa2Cu4O8, which reveals that these pockets are electron-like rather than hole-like. We propose that these electron pockets most probably arise from a reconstruction of the Fermi surface caused by the onset of a density-wave phase, as is thought to occur in the electron-doped copper oxides near the onset of antiferromagnetic order. Comparison with materials of the La2CuO4 family that exhibit spin/charge density-wave order suggests that a Fermi surface reconstruction also occurs in those materials, pointing to a generic property of high-transition-temperature (T(c)) superconductors. 相似文献