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51.
T Aoyagi T Wada M Nagai F Kojima S Harada T Takeuchi H Takahashi K Hirokawa T Tsumita 《Experientia》1990,46(1):94-97
We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2 x 10(-7) M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease. 相似文献
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53.
Karyotypes of Myotis siligorensis, Myotis mystacinus, Pipistrellus pulveratus, Tylonycteris robustula, Miniopterus schreibersi fuliginosus, Hipposideros fulvus and Aselliscus stoliczkanus from Thailand are investigated. 相似文献
54.
T Aoyagi T Wada F Kojima M Nagai S Harada T Takeuchi K Isse M Ogura M Hamamoto K Tanaka 《Experientia》1992,48(7):656-659
Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients. 相似文献
55.
56.
Control of osteoblast function and regulation of bone mass 总被引:41,自引:0,他引:41
The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course. 相似文献
57.
二成分混合流体Rayleigh-Benard对流 总被引:6,自引:0,他引:6
Rayleigh-Benard(RB)对流是研究非平衡对流的稳定性、非线性动力学特性及湍流形成机理的典型模型之一。在介绍RB对流研究方法的基础上,论述了其最新研究进展:混合流体RB对流运动的稳定性及其非线性动力特性;RB对流与水平流动相耦合时的非线性动力特性。最后提出了有待进一步研究和探讨的问题。 相似文献
58.
59.
Heterozygous TGFBR2 mutations in Marfan syndrome 总被引:24,自引:0,他引:24
Mizuguchi T Collod-Beroud G Akiyama T Abifadel M Harada N Morisaki T Allard D Varret M Claustres M Morisaki H Ihara M Kinoshita A Yoshiura K Junien C Kajii T Jondeau G Ohta T Kishino T Furukawa Y Nakamura Y Niikawa N Boileau C Matsumoto N 《Nature genetics》2004,36(8):855-860
Marfan syndrome is an extracellular matrix disorder with cardinal manifestations in the eye, skeleton and cardiovascular systems associated with defects in the gene encoding fibrillin (FBN1) at 15q21.1 (ref. 1). A second type of the disorder (Marfan syndrome type 2; OMIM 154705) is associated with a second locus, MFS2, at 3p25-p24.2 in a large French family (family MS1). Identification of a 3p24.1 chromosomal breakpoint disrupting the gene encoding TGF-beta receptor 2 (TGFBR2) in a Japanese individual with Marfan syndrome led us to consider TGFBR2 as the gene underlying association with Marfan syndrome at the MSF2 locus. The mutation 1524G-->A in TGFBR2 (causing the synonymous amino acid substitution Q508Q) resulted in abnormal splicing and segregated with MFS2 in family MS1. We identified three other missense mutations in four unrelated probands, which led to loss of function of TGF-beta signaling activity on extracellular matrix formation. These results show that heterozygous mutations in TGFBR2, a putative tumor-suppressor gene implicated in several malignancies, are also associated with inherited connective-tissue disorders. 相似文献
60.
Matsuzaki M Misumi O Shin-I T Maruyama S Takahara M Miyagishima SY Mori T Nishida K Yagisawa F Nishida K Yoshida Y Nishimura Y Nakao S Kobayashi T Momoyama Y Higashiyama T Minoda A Sano M Nomoto H Oishi K Hayashi H Ohta F Nishizaka S Haga S Miura S Morishita T Kabeya Y Terasawa K Suzuki Y Ishii Y Asakawa S Takano H Ohta N Kuroiwa H Tanaka K Shimizu N Sugano S Sato N Nozaki H Ogasawara N Kohara Y Kuroiwa T 《Nature》2004,428(6983):653-657
Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support the lives of photosynthetic eukaryotes, including higher plants. Here we report the 16,520,305-base-pair sequence of the 20 chromosomes of the unicellular red alga Cyanidioschyzon merolae 10D as the first complete algal genome. We identified 5,331 genes in total, of which at least 86.3% were expressed. Unique characteristics of this genomic structure include: a lack of introns in all but 26 genes; only three copies of ribosomal DNA units that maintain the nucleolus; and two dynamin genes that are involved only in the division of mitochondria and plastids. The conserved mosaic origin of Calvin cycle enzymes in this red alga and in green plants supports the hypothesis of the existence of single primary plastid endosymbiosis. The lack of a myosin gene, in addition to the unexpressed actin gene, suggests a simpler system of cytokinesis. These results indicate that the C. merolae genome provides a model system with a simple gene composition for studying the origin, evolution and fundamental mechanisms of eukaryotic cells. 相似文献