Lymphocyte responses to phytohemagglutinin in rheumatoid arthritis and glomerulonephritis and the effects of immunosuppression

Résumé La transformation lymphocytaire en phytohemagglutinine est étudiée chez des individus normaux, aussi bien que chez des malades souffrant de glomérulonéphrites aiguës et chroniques ainsi que de polyarthrite rhumatoïde. La réponse des glomérulonéphritiques fut conforme aux contrôles, les polyarthritiques eurent des réponses affaiblies. La transformation lymphocytaire est fortement réduite chez les patients sous immunosuppression.

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From the Gwynne Hazen Cherry Memorial Laboratories, Department of Pediatrics, University of California Medical Center for Health Sciences, Los Angeles, California and Divisions of Nephrology and Immunology, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, 630 W. 168th. St., New York, N.Y. 10032, USA.     

Simulation and uniform design-based automatic generation of risk scenarios

This paper presents a methodology for automatically generating risk scenarios for dynamic reliability applications in which some dynamic characteristics(e.g.,the order,timing and magnitude of events,the value of relevant process parameters and initial conditions) have a significant influence on the evolution of the system.The main idea of the methodology is:(i) making the system model "express itself" through simulation by having the model driven by an elaborated simulation engine;(ii) exploiting uniform design to pick out a small subset of representative design points from the space of relevant dynamic characteristics;(iii) for each selected design point,employing a depth-first systematic exploration strategy to cover all possible scenario branches at each branch point.A highly dynamic example adapted from the literature(a chemical batch reactor) is studied to test the effectiveness of the proposed methodology.     

Effective Approach to Elevate the Intelligence of Management Decision System

Based on the sticking point of the low intelligence of the existing management decision system, this paper puts forward the idea of enriching and refining the knowledge of the system and endowing it with the ability to learn by means of adopting three types of heterogeneous knowledge representation and knowledge management measures. At length, this paper outlines the basic framework of an intelligence system for the sake of management decision problem.