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71.
In multicellular organisms, the coordination of cell behaviors largely relies on biochemical and biophysical signals. Understanding
how such signals control development is often challenging, because their distribution relies on the activity of individual
cells and, in a feedback loop, on tissue behavior and geometry. This review focuses on one of the best-studied structures
in biology, the shoot apical meristem (SAM). This tissue is responsible for the production of all the aerial parts of a plant.
In the SAM, a population of stem cells continuously produces new cells that are incorporated in lateral organs, such as leaves,
branches, and flowers. Organogenesis from stem cells involves a tight regulation of cell identity and patterning as well as
large-scale morphogenetic events. The gene regulatory network controlling these processes is highly coordinated in space by
various signals, such as plant hormones, peptides, intracellular mobile factors, and mechanical stresses. Many crosstalks
and feedback loops interconnecting these pathways have emerged in the past 10 years. The plant hormone auxin and mechanical
forces have received more attention recently and their role is more particularly detailed here. An integrated view of these
signaling networks is also presented in order to help understanding how robust shape and patterning can emerge from these
networks. 相似文献
72.
Corinne Abbadie Olivier Pluquet Albin Pourtier 《Cellular and molecular life sciences : CMLS》2017,74(24):4471-4509
Senescence is a cell state occurring in vitro and in vivo after successive replication cycles and/or upon exposition to various stressors. It is characterized by a strong cell cycle arrest associated with several molecular, metabolic and morphologic changes. The accumulation of senescent cells in tissues and organs with time plays a role in organismal aging and in several age-associated disorders and pathologies. Moreover, several therapeutic interventions are able to prematurely induce senescence. It is, therefore, tremendously important to characterize in-depth, the mechanisms by which senescence is induced, as well as the precise properties of senescent cells. For historical reasons, senescence is often studied with fibroblast models. Other cell types, however, much more relevant regarding the structure and function of vital organs and/or regarding pathologies, are regrettably often neglected. In this article, we will clarify what is known on senescence of epithelial cells and highlight what distinguishes it from, and what makes it like, replicative senescence of fibroblasts taken as a standard. 相似文献
73.
The fact that there exist in nature thoroughly deterministic systems whose future behavior cannot be predicted, no matter how advanced or fined-tune our cognitive and technical abilities turn out to be, has been well established over the last decades or so, essentially in the light of two different theoretical frameworks, namely chaos theory and (some deterministic interpretation of) quantum mechanics. The prime objective of this paper is to show that there actually exists an alternative strategy to ground the divorce between determinism and predictability, a way that is older than—and conceptually independent from—chaos theory and quantum mechanics, and which has not received much attention in the recent philosophical literature about determinism. This forgotten strategy—embedded in the doctrine called “emergent evolutionism”—is nonetheless far from being a mere historical curiosity that should only draw the attention of philosophers out of their concern for comprehensiveness. It has been indeed recently revived in the works of respected scientists. 相似文献
74.
Kaminsky R Ducray P Jung M Clover R Rufener L Bouvier J Weber SS Wenger A Wieland-Berghausen S Goebel T Gauvry N Pautrat F Skripsky T Froelich O Komoin-Oka C Westlund B Sluder A Mäser P 《Nature》2008,452(7184):176-180
Anthelmintic resistance in human and animal pathogenic helminths has been spreading in prevalence and severity to a point where multidrug resistance against the three major classes of anthelmintics--the benzimidazoles, imidazothiazoles and macrocyclic lactones--has become a global phenomenon in gastrointestinal nematodes of farm animals. Hence, there is an urgent need for an anthelmintic with a new mode of action. Here we report the discovery of the amino-acetonitrile derivatives (AADs) as a new chemical class of synthetic anthelmintics and describe the development of drug candidates that are efficacious against various species of livestock-pathogenic nematodes. These drug candidates seem to have a novel mode of action involving a unique, nematode-specific clade of acetylcholine receptor subunits. The AADs are well tolerated and of low toxicity to mammals, and overcome existing resistances to the currently available anthelmintics. 相似文献
75.
Control of segment number in vertebrate embryos 总被引:1,自引:0,他引:1
The vertebrate body axis is subdivided into repeated segments, best exemplified by the vertebrae that derive from embryonic somites. The number of somites is precisely defined for any given species but varies widely from one species to another. To determine the mechanism controlling somite number, we have compared somitogenesis in zebrafish, chicken, mouse and corn snake embryos. Here we present evidence that in all of these species a similar 'clock-and-wavefront' mechanism operates to control somitogenesis; in all of them, somitogenesis is brought to an end through a process in which the presomitic mesoderm, having first increased in size, gradually shrinks until it is exhausted, terminating somite formation. In snake embryos, however, the segmentation clock rate is much faster relative to developmental rate than in other amniotes, leading to a greatly increased number of smaller-sized somites. 相似文献
76.
Jaillon O Bouhouche K Gout JF Aury JM Noel B Saudemont B Nowacki M Serrano V Porcel BM Ségurens B Le Mouël A Lepère G Schächter V Bétermier M Cohen J Wincker P Sperling L Duret L Meyer E 《Nature》2008,451(7176):359-362
Most eukaryotic genes are interrupted by non-coding introns that must be accurately removed from pre-messenger RNAs to produce translatable mRNAs. Splicing is guided locally by short conserved sequences, but genes typically contain many potential splice sites, and the mechanisms specifying the correct sites remain poorly understood. In most organisms, short introns recognized by the intron definition mechanism cannot be efficiently predicted solely on the basis of sequence motifs. In multicellular eukaryotes, long introns are recognized through exon definition and most genes produce multiple mRNA variants through alternative splicing. The nonsense-mediated mRNA decay (NMD) pathway may further shape the observed sets of variants by selectively degrading those containing premature termination codons, which are frequently produced in mammals. Here we show that the tiny introns of the ciliate Paramecium tetraurelia are under strong selective pressure to cause premature termination of mRNA translation in the event of intron retention, and that the same bias is observed among the short introns of plants, fungi and animals. By knocking down the two P. tetraurelia genes encoding UPF1, a protein that is crucial in NMD, we show that the intrinsic efficiency of splicing varies widely among introns and that NMD activity can significantly reduce the fraction of unspliced mRNAs. The results suggest that, independently of alternative splicing, species with large intron numbers universally rely on NMD to compensate for suboptimal splicing efficiency and accuracy. 相似文献
77.
78.
79.
Discovery of an aurora on Mars 总被引:1,自引:0,他引:1
Bertaux JL Leblanc F Witasse O Quemerais E Lilensten J Stern SA Sandel B Korablev O 《Nature》2005,435(7043):790-794
In the high-latitude regions of Earth, aurorae are the often-spectacular visual manifestation of the interaction between electrically charged particles (electrons, protons or ions) with the neutral upper atmosphere, as they precipitate along magnetic field lines. More generally, auroral emissions in planetary atmospheres "are those that result from the impact of particles other than photoelectrons" (ref. 1). Auroral activity has been found on all four giant planets possessing a magnetic field (Jupiter, Saturn, Uranus and Neptune), as well as on Venus, which has no magnetic field. On the nightside of Venus, atomic O emissions at 130.4 nm and 135.6 nm appear in bright patches of varying sizes and intensities, which are believed to be produced by electrons with energy <300 eV (ref. 7). Here we report the discovery of an aurora in the martian atmosphere, using the ultraviolet spectrometer SPICAM on board Mars Express. It corresponds to a distinct type of aurora not seen before in the Solar System: it is unlike aurorae at Earth and the giant planets, which lie at the foot of the intrinsic magnetic field lines near the magnetic poles, and unlike venusian auroras, which are diffuse, sometimes spreading over the entire disk. Instead, the martian aurora is a highly concentrated and localized emission controlled by magnetic field anomalies in the martian crust. 相似文献
80.