怎样利用Visual Basic制作PowerPoint多媒体课堂时间显示器

针对现代多媒体课堂教学中,PowerPoint全屏放映时无法看到系统时间,影响教学效率这一问题,本文介绍了利用V isual Basic制作PowerPoint多媒体课堂时间显示器的设计思想和方法.     

两点边值问题Daubechies小波δ-序列数值解法

使用广义函数δ-序列方法数值求解两点边值问题.这种δ-序列以Daubechies小波为基础,具有紧支、对称、拟插值的性质.以对流占优方程为例,空间导数采用Daubechies小波δ-序列作数值格式离散,验证了该方法的有效性.使用Daubechies小波δ-序列数值方法求解两点边值问题,方法简单,能方便地处理各类边值问题,计算精度高.数值算例表明,Daubechies小波δ-序列数值方法不仅能够较好地求解具有边界层的两点边值问题,而且可以非常方便地求解具有较高阶导数的梁、板等力学问题.     

动态环境下基于势场原理的避障方法

在保留传统人工势场法原理简单、易于实现优点的基础上,对其应用在具有移动障碍物的动态环境中所表现出的缺陷进行了改进,用碰撞时间参数代替相对位置参数并辅以碰撞角度约束来消除无渭的避碰运动,同时又引入障碍物作用于机器人、方向指向目标点的分力和局部波动函数,较好地解决了因局部最小以及障碍物与目标点相距太近造成的不能成功到达目标点的问题．仿真结果表明此方法能够使机器人在具有静态和移动障碍物的复杂环境中安全避障．     

电子电路设计有关问题的探讨

分析了电子电路设计在低频电子电路,高频电子电路,数字电路,印制版制作过程中应注意的实际问题,以提高设计者设计成功的一次性。     

Activation of ataxia telangiectasia muted under experimental models and human Parkinson’s disease

In the present study we demonstrated that neurotoxin MPP⁺-induced DNA damage is followed by ataxia telangiectasia muted (ATM) activation either in cerebellar granule cells (CGC) or in B65 cell line. In CGC, the selective ATM inhibitor KU-55933 showed neuroprotective effects against MPP⁺-induced neuronal cell loss and apoptosis, lending support to the key role of ATM in experimental models of Parkinson’s disease. Likewise, we showed that knockdown of ATM levels in neuroblastoma B65 cells using an ATM-specific siRNA attenuates the phosphorylation of retinoblastoma protein without affecting other cell-cycle proteins involved in the G₀/G₁ cell-cycle phase. Moreover, we demonstrated DNA damage, in human brain samples of PD patients. These findings support a model in which MPP⁺ leads to ATM activation with a subsequent DNA damage response and activation of pRb. Therefore, this study demonstrates a new link between DNA damage by MPP⁺ and cell-cycle re-entry through retinoblastoma protein phosphorylation.     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

自调式镦压挤胀复合液压机的研制

从力学原理、设计原理、整机结构、关键零部件的设计和工作程序,系统地介绍了自调式镦压挤胀复合液压机．由于压机设计了顶出缸对下活动横梁调节限位结构,回程拉杆对上镦压横梁的复位结构及镦压缸和气液储能器之间的连通协调结构,这不仅使该液压机结构紧凑,同时节省了上镦压横梁的回程液压缸、下活动横梁的镦压缸,并简化了上凸模与上镦压模分设的液压系统,而且解决了直齿圆柱齿轮在塑性成形过程中齿顶难以充满、齿根易出现微裂纹,以及成形压力过大和模具寿命过低的问题．     

广义进化的定义

广义进化的基本理论,尤其是一些基本概念有待研究。要找到广义进化的准确定义,必须分析清楚四个关系：第一,有序与适应性的关系;第二,进化与复杂化的关系;第三,复杂与有序的关系;第四,复杂与适应性的关系。序参量的评价标准应该是系统功能的总价值,只有当系统的新结构导致新功能出现时,才会使有序度增大。进化就是复杂化,复杂化就是创新,就是对称性破缺程度增大的过程,广义进化是所有物质系统的复杂化过程。     

Galanin – 25 years with a multitalented neuropeptide

Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Over the past decade, some of the receptor subtype-specific effects have been elucidated through pharmacological studies using subtype selective ligands, as well as through molecular approaches involving knockout animals. In the present review, we summarize the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.