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51.
R. B. Davis 《Cellular and molecular life sciences : CMLS》1968,24(2):175-177
Zusammenfassung Die Aggregation von Blutplättchen durchEscherichia coli Endotoxin wurde untersucht: Die Blutplättchenanhäufung erweist sich anfänglich als langsam, dann aber als sehr schnelle Abnahme der optischen Dichte eines blutplättchenreichen Plasmas. Die schnelle Abnahme der optischen Dichte konnte durch Heparin, und zwar nur in grösserer Menge, unterdrückt werden. Der Beginn der schnellen Ansammlung wurde durch Adenosin verzögert, wobei aber Adenosin keine Wirkung auf den Grad der Anhäufung durch das Endotoxin hatte. Die Ergebnisse weisen darauf hin, dass in vitro Thrombin und Adenosindiphosphat die Thrombozytenaggregation durch Endotoxin unterstützen.
Supported by U.S.P.H.S. grant No. H-7150.
U.S.P.H.S. Research Career Development Award Recipient. 相似文献
Supported by U.S.P.H.S. grant No. H-7150.
U.S.P.H.S. Research Career Development Award Recipient. 相似文献
52.
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 总被引:18,自引:0,他引:18
Loeys BL Chen J Neptune ER Judge DP Podowski M Holm T Meyers J Leitch CC Katsanis N Sharifi N Xu FL Myers LA Spevak PJ Cameron DE De Backer J Hellemans J Chen Y Davis EC Webb CL Kress W Coucke P Rifkin DB De Paepe AM Dietz HC 《Nature genetics》2005,37(3):275-281
We report heterozygous mutations in the genes encoding either type I or type II transforming growth factor beta receptor in ten families with a newly described human phenotype that includes widespread perturbations in cardiovascular, craniofacial, neurocognitive and skeletal development. Despite evidence that receptors derived from selected mutated alleles cannot support TGFbeta signal propagation, cells derived from individuals heterozygous with respect to these mutations did not show altered kinetics of the acute phase response to administered ligand. Furthermore, tissues derived from affected individuals showed increased expression of both collagen and connective tissue growth factor, as well as nuclear enrichment of phosphorylated Smad2, indicative of increased TGFbeta signaling. These data definitively implicate perturbation of TGFbeta signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events. 相似文献
53.
Identifying the genetic variation underlying quantitative trait loci remains problematic. Consequently, our molecular understanding of genetically complex, quantitative traits is limited. To address this issue directly, we mapped three quantitative trait loci that control yeast sporulation efficiency to single-nucleotide resolution in a noncoding regulatory region (RME1) and to two missense mutations (TAO3 and MKT1). For each quantitative trait locus, the responsible polymorphism is rare among a diverse set of 13 yeast strains, suggestive of genetic heterogeneity in the control of yeast sporulation. Additionally, under optimal conditions, we reconstituted approximately 92% of the sporulation efficiency difference between the two genetically distinct parents by engineering three nucleotide changes in the appropriate yeast genome. Our results provide the highest resolution to date of the molecular basis of a quantitative trait, showing that the interaction of a few genetic variants can have a profound phenotypic effect. 相似文献
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Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is achieved, we constructed soluble peptide-MHC heterodimers in which one peptide is an agonist and the other is one of the large number of endogenous peptide-MHCs displayed by presenting cells. We found that some specific combinations of these heterodimers can stimulate specific T cells in a CD4-dependent manner. This activation is severely impaired if the CD4-binding site on the agonist ligand is ablated, but the same mutation on an endogenous ligand has no effect. These data correlate well with analyses of lipid bilayers and cells presenting these ligands, and indicate that the basic unit of helper T cell activation is a heterodimer of agonist peptide- and endogenous peptide-MHC complexes, stabilized by CD4. 相似文献
57.
W. Davis 《Cellular and molecular life sciences : CMLS》1959,15(8):294-297
Zusammenfassung Die Chemotherapie von bösartigen Gechwülsten und Leukämien wurde am VII. Internationalen Krebskongress in London sowohl vom Gesichtspunkt der Klinik wie von demjenigen der experimentellen Forschung aus behandelt.Nahezu alle in diesem Zusammenhang erwähnten Pharmaka gehören entweder zur Gruppe der Alkylierungsmittel oder aber zu derjenigen der Stoffwechselantagonisten.Das klinische Interesse galt vor allem der Verbesserung von therapeutischen Anwendungsweisen bereits anerkannter Heilmittel, deren Brauchbarkeit zur Unterstützung der Chirurgie, sowie der Prüfung neuartiger Substanzen mit möglicher Hemmungswirkung auf Tumoren.Die Beiträge auf dem experimentellen Gebiet umfassten biochemische Studien über den Wirkungsmechanismus von Krebspharmaka und über den biologischen Einbau von Stoffwechselantagonisten. Einige Vorträge behandelten die Frage, welche Bedeutung den Enzymen in der Chemotherapie des Krebses zukomme.
The Abstracts of the VIIth International Cancer Congress were published under the auspices of the International Union against Cancer in London, July 1958. The full reports of the Congress will be published in a special edition of the ACTA of the International Union against Cancer. 相似文献
The Abstracts of the VIIth International Cancer Congress were published under the auspices of the International Union against Cancer in London, July 1958. The full reports of the Congress will be published in a special edition of the ACTA of the International Union against Cancer. 相似文献
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59.
Effect of lithium on the uptake of noradrenaline by synaptosomes 总被引:4,自引:0,他引:4
60.