含反馈控制的非自治3种群捕食系统的持续性

讨论了一类具有反馈控制的非自治3种群捕食系统的持续性和周期解,证明了在适当条件下该系统是持续生存的,得到该系统存在周期解的充分条件,并举例说明了定理的可实现性.     

基于非圆信号特征的实值张量ESPRIT算法

基于最大非圆率非圆信号特点,提出一种实值张量旋转不变子空间(estimation signal parameters via rotational invariance techniques, ESPRIT)算法。首先,通过研究张量与矩阵之间的转化关系,将阵列接收数据矩阵推广到张量空间;然后,利用欧拉公式将阵列接收数据张量转化成余弦与正弦数据张量,根据阵列维数将其分别在各维上加以拼接,并对拼接的实值数据张量做高阶奇异值分解,获取信号子空间;最后,通过构造选择矩阵和进行特征分解,来联合估计阵列各维相位差,实现波达方向估计。实验仿真结果表明,此算法具有良好的分辨力和测角精度。     

二相编码信号调制分析与识别

针对采用脉冲压缩体制的低截获概率雷达的应用场合,提出了一种识别二相编码脉冲压缩雷达信号的新算法。该算法基于信号的时频分析(小波分析和短时傅里叶变换),利用小波变换的相位尺度和载波尺度的模极大值特征辨识信号的相位调制规律,因而在无需计算全部小波系数的情况下,可快速地获得信号的数学模型,为算法在实际中的应用提供了良好的条件。给出了应用该方法的具体步骤,通过计算机仿真实验证明该算法的有效性。     

Mutations of the BRAF gene in human cancer

Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis signalling pathways in which at least one gene is mutated in human cancer. The RAS RAF MEK ERK MAP kinase pathway mediates cellular responses to growth signals. RAS is mutated to an oncogenic form in about 15% of human cancer. The three RAF genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. All mutations are within the kinase domain, with a single substitution (V599E) accounting for 80%. Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma.     

PbTe薄膜磁控溅射生长及其微结构研究

利用磁控溅射法在BaF2（111）单晶衬底上生长了PhTe薄膜,通过原子力显微镜（AFM）、X射线衍射（XRD）、傅里叶红外透射谱（FTIR）表征了溅射PbTe/BaF2（111）薄膜的微结构和光学特性．测量结果显示：溅射生长的PbTe／BaF2（111）薄膜表面由规则金字塔形岛和三角形坑组成的纳米颗粒构成,且薄膜沿〈111〉取向择优生长,其晶粒大小与表面纳米颗粒大小接近．室温下傅里叶红外透射谱及其理论模拟表明溅射生长的PbTe薄膜光学吸收带隙（Eg=0．351eV）出现蓝移,与PbTe纳米晶粒的尺寸效应有关．     

一种结构化P2P存储系统的负载均衡方法

针对结构化P2P存储系统中的负载不均衡问题,提出了一种基于虚节点划分的负载均衡方法.建立适用于P2P存储系统的节点性能模型,对网络节点进行性能评价,将物理网络中性能弱的临近节点划分成DHT网络中的一个虚拟节点以平衡系统的负载.实验结果表明该方法可以有效降低结构化P2P存储系统中负载不均衡节点的数量.     

基于平衡计分卡的高校战略绩效管理研究

目前高校绩效管理存在"借来"主义、考核指标设计不科学不全面等问题,尝试从平衡计分卡管理模式对高校绩效评价进行设计,通过对传统平衡计分卡体系的改进、战略地图的绘制以及战略中心组织的引入,来完善高校的绩效评价体系。     

平面图形设计中符号学原理的应用

图形设计作为视觉传达设计中的一种符号设计现象,其成功所在,是能得以运用设计的符号学原理不断挖掘其深处的潜质,并与人们内心深处的情感相沟通。因此,应该对此进行研究与认识,发掘更多的符号特性,更准确的运用符号学原理来进行平面图形设计。     

中国体育教师教育研究热点与前沿的可视化分析

研究以中国期刊网143篇体育教师教育相关核心期刊文献为研究对象,运用Citespace、Ucinet等可视化软件对该领域的作者、研究机构、研究热点及内容等进行系统分析。研究发现:我国体育教师教育领域的研究文献数量呈现逐年稳步上升的趋势;作者机构分布多为高校体育院系,作者数量多但合作程度不高;研究热点中体育教师专业化、体育教师教育的发展方式问题是重点;体育教师教育领域主要关注的是体育教师教育现状分析、百年来的反思进取、国际比较与借鉴、专业化发展途径。     

Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.

During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is accomplished through spontaneous folding to a thermodynamically stable and active native state. However, in the extracellular bacterial alpha-lytic protease (alphaLP) these two processes have become decoupled. The native state of alphaLP is thermodynamically unstable, and when denatured, requires millennia (t1/2 approximately 1,800 years) to refold. Folding is made possible by an attached folding catalyst, the pro-region, which is degraded on completion of folding, leaving alphaLP trapped in its native state by a large kinetic unfolding barrier (t1/2 approximately 1.2 years). alphaLP faces two very different folding landscapes: one in the presence of the pro-region controlling folding, and one in its absence restricting unfolding. Here we demonstrate that this separation of folding and unfolding pathways has removed constraints placed on the folding of thermodynamically stable proteins, and allowed the evolution of a native state having markedly reduced dynamic fluctuations. This, in turn, has led to a significant extension of the functional lifetime of alphaLP by the optimal suppression of proteolytic sensitivity.