Time Series of Zero‐Inflated Counts and their Coherent Forecasting

Poisson integer‐valued auto‐regressive process of order 1 (PINAR(1)) due to Al‐Osh and Alzaid (Journal of Time Series Analysis 1987; 8 (3): 261–275) and McKenzie (Advances in Applied Probability 1988; 20 (4): 822–835) has received a significant attention in modelling low‐count time series during the last two decades because of its simplicity. But in many practical scenarios, the process appears to be inadequate, especially when data are overdispersed in nature. This overdispersion occurs mainly for three reasons: presence of some extreme values, large number of zeros, and presence of both extreme values with a large number of zeros. In this article, we develop a zero‐inflated Poisson INAR(1) process as an alternative to the PINAR(1) process when the number of zeros in the data is larger than the expected number of zeros by the Poisson process. We investigate some important properties such as stationarity, ergodicity, autocorrelation structure, and conditional distribution, with a detailed study on h‐step‐ahead coherent forecasting. A comparative study among different methods of parameter estimation is carried out using some simulated data. One real dataset is analysed for practical illustration. Copyright © 2015 John Wiley & Sons, Ltd.     

Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes

The polyunsaturated fatty acids (PUFAs), linoleic acid (LA), alpha linolenic acid (ALA), gamma linolenic acid (GLA), arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), showed inhibition of growth of both normal and abnormal (Molt-4) human lymphocytes, and inhibition was concentration-dependent. Interestingly, the production of the lymphokine Interleukin-2 (IL-2) was elevated in Molt-4 cells, but it was reduced in the normal human lymphocytes. Addition of GLA or IL-2 or a combination of both showed enhancement of SO ₂ ^– and of lipid peroxidation levels, which were significantly higher in Molt-4 cells than in the normal lymphocytes. Reduction of protein concentration was also observed in both types of cells during this treatment. The data showed that the antiproliferative effects of GLA and IL-2 may partly be exerted through the elevated production of superoxide free radicals and peroxidatin products. This is a novel finding and therefore, further exploitation of combinations of PUFAs and IL-2 may be a possible way of combating cancer cell growth.     

Toward interoperable bioscience data

To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability and promote the growth of an open 'data commoning' culture. Here we describe the prerequisites for data commoning and present an established and growing ecosystem of solutions using the shared 'Investigation-Study-Assay' framework to support that vision.     

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.     

Effect of thiamine hydrochloride on the blood level of 2-formyl 1-methyl pyridinium oxime chloride (2-PAM.Cl) in rats

Summary The biological half-life of 2-PAM.Cl was found to increase in female rats pretreated with thiamine hydrochloride (10 mg/kg i.m.). No such effect was observed in the male rats.Dr B.L. Chowdhri very kindly synthesized the compound 2-PAM.Cl in the Department of Chemistry of this establishment for this work.The authors are thankful to Dr P.K. Ramachandran, Director, and Dr A.K. Chatterjee, Deputy Director, Defence Research and Development Establishment, Gwalior, for their keen interest in this work.     

Effects of Ethylnitrosourea on the development of brain

Zusammenfassung Wiederholte Applikation von Äthynitroso-Harnstoff bei trächtigen Ratten bewirkt bei Föten eine Hemmung der Gehirnentwicklung, wobei vor allem die hemisphären und das Cerebellum unterentwickelt bleiben. Diese Hemmung ist am ausgeprägtesteniw wenn die Behandlung am 14. Tag der Trächtigkeit einsetzt.     

A new strain ofAspergillus niger producing citric acid

Zusammenfassung Durch Behandlung eines Zitronensäure produzierenden Stammes vonAspergillus niger mit-Strahlen, N-Lost und UV-Strahlen konnte die Zitronensäureausbeute um ungefähr das Vierfache gesteigert werden.     

Isolation of the two paragonial substances deposited into the spermatophores ofAcanthoscelides obtectus (Coleoptera,Bruchidae)

Summary Aqueous extracts from spermatophores ofAcanthoscelides obtectus (Coleoptera, Bruchidae) have been chromatographed on Sephadex G 25 and G 15 columns, the active fractions being further purified by preparative SiO₂ TLC. The isolation and properties of 2 biologically active compounds are reported. The paragonial substance A has a favourable action upon oogenesis, is a low molecular weight molecule (500–1000) and gives 1 single amino acid on hydrolysis, corresponding to glycin on TLC. The paragonial substance B is toxic, or an inhibitor of oogenesis at lower concentration, thus showing an antagonistic effect.