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71.
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73.
Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: (1) x-ray analysis 总被引:6,自引:0,他引:6
M F Perutz H Miurhead J M Cox L C Goaman F S Mathews E L McGandy L E Webb 《Nature》1968,219(5149):29-32
74.
Many bacteria are capable of interacting with platelets and inducing platelet aggregation. This interaction may be a direct
interaction between a bacterial surface protein and a platelet receptor or may be an indirect interaction where plasma proteins
bind to the bacterial surface and subsequently bind to a platelet receptor. However, these interactions usually do not trigger
platelet activation as a secondary co-signal is also required. This is usually due to specific antibody bound to the bacteria
interacting with FcγRIIa on the platelet surface. Secreted bacterial products such as gingipains and lipopolysaccharide may
also be capable of triggering platelet activation. 相似文献
75.
A General Weighted Two-Way Dissimilarity Coefficient 总被引:1,自引:1,他引:0
76.
Malaria is a major cause of morbidity and mortality in the developing world and cerebral malaria is responsible for the majority
of malaria-associated deaths. There is a strong association between thrombocytopenia and outcome in malaria, suggesting a
role for platelets in the pathogenesis of malaria. This thrombocytopenia is likely due to platelet activation possibly through
an interaction between PfEMP1 on plasmodium and CD36 on platelets. Platelet activation by plasmodium has two potential consequences.
It can lead to the formation of micro-aggregates of infected red blood cells and platelets which can occlude blood vessels
and it also leads to binding to and activation of the endothelium. 相似文献
77.
Studies have demonstrated that some riparian trees may switch their reliance on surface soil water (unsaturated or vadose zone) to groundwater (saturated zone) sources during the growing season in association with changes in moisture availability. A closely related question is: How do these trees respond to pulse increases in water availability in previously dry zones? We tested the whole-tree physiological response of 6 natural Populus genotypes to water additions during the peak of summer drought in northern Utah, USA. We found clear evidence that trees were insensitive to water additions to the surface soil that were twice the magnitude of whole-tree transpiration rates. Our results suggest that some cottonwoods may have little immediate transpiration or leaf conductance response to pulse soil moisture increases. This lack of response may be related to a water-use strategy associated with regional climate patterns (i.e., genetic or environmental programming), cavitation recovery, or other physical determinants of water use such as depth to groundwater. Our data suggest that it is important to consider potential nonresponsiveness to changes in soil water availability when evaluating the impact of climate change on these important and productive ecosystems. 相似文献
78.
Form and dispersion of Mima mounds in relation to slope steepness and aspect on the Columbia Plateau
George W. Cox 《西北部美国博物学家》2011,50(1)
Patterned ground consisting of Mima-type earth mounds and associated sorted stone circles and nets is widespread on the Columbia Plateau of western North America. Studies of the geometric relationships of mounds and stone nets to slope aspect and steepness were carried out at the Lawrence Memorial Grassland Preserve, north central Oregon in June 1987. Mound and moundfield characteristics were sampled on randomly chosen 1-ha plots on slopes of different aspect and steepness. Mounds were largest, most circular and symmetrical in form, and most fully encircled by beds of size-sorted stones on level sites. On slopes of increasing steepness, mounds decreased in size, showed increasing asymmetry and downslope elongation, and became connected into lines oriented up- and downslope. Encircling stone beds became more weakly developed or disappeared on upslope and downslope sides of the mounds, and the lateral beds developed downslope extensions that eventually merged with those of adjacent upslope and downslope mounds. These patterns are interpreted as reflecting changes in the manner of soil translocation by northern pocket gophers, Thomomys talpoides , due to their responses to tunneling on slopes and to the modification of the flow of water across the slope because of the presence of mounds. 相似文献
79.
A detailed study of the anterior osteology and myology of Callisaurus, Cophosaurus, Holbrookia, and Uma reveals the phylogenetic relationships among the sand lizards. An SPSS discriminant analysis of osteological characters combined with myological characters indicates that Callisaurus is most primitive, Cophosaurus and Holbrookia are most closely related, and Uma is the most distinct of the sand lizard genera. Because of close relationships between Cophosaurus and Holbrookia, it is postulated that earlessness evolved once, and Cophosaurus is returned to synonymy under Holbrookia. 相似文献
80.
Sugar transporters for intercellular exchange and nutrition of pathogens 总被引:10,自引:0,他引:10
Chen LQ Hou BH Lalonde S Takanaga H Hartung ML Qu XQ Guo WJ Kim JG Underwood W Chaudhuri B Chermak D Antony G White FF Somerville SC Mudgett MB Frommer WB 《Nature》2010,468(7323):527-532
Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells. 相似文献