超支化不饱和聚(酰胺-酯)的改性及热分解动力学

采用不同链长的十四酰氯和十八酰氯对超支化不饱和聚(酰胺-酯)(MHBP)的端羟基进行原位端基改性,制备出2种改性超支化聚合物,用傅立叶红外光谱(FTIR)、热重分析(TGA)、黏度法等对其结构及性能进行表征,并研究了它们的热分解行为及其热分解动力学.结果表明,其热分解反应不是一级反应,改性超支化聚合物的热稳定性与末端烷烃链的长度有关,用Ozawa法求出了热分解表观活化能.     

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

Epithelial organs, including the lung, are known to possess regenerative abilities through activation of endogenous stem cell populations, but the molecular pathways regulating stem cell expansion and regeneration are not well understood. Here we show that Gata6 regulates the temporal appearance and number of bronchioalveolar stem cells (BASCs) in the lung, its absence in Gata6-null lung epithelium leading to the precocious appearance of BASCs and concurrent loss in epithelial differentiation. This expansion of BASCs was the result of a pronounced increase in canonical Wnt signaling in lung epithelium upon loss of Gata6. Expression of the noncanonical Wnt receptor Fzd2 was downregulated in Gata6 mutants and increased Fzd2 or decreased beta-catenin expression rescued, in part, the lung epithelial defects in Gata6 mutants. During lung epithelial regeneration, canonical Wnt signaling was activated in the niche containing BASCs and forced activation of Wnt signaling led to a large increase in BASC numbers. Moreover, Gata6 was required for proper lung epithelial regeneration, and postnatal loss of Gata6 led to increased BASC expansion and decreased differentiation. Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration.     

Chromosome boundary elements and regulation of heterochromatin spreading

Chromatin is generally classified as euchromatin or heterochromatin, each with distinct histone modifications, compaction levels, and gene expression patterns. Although the proper formation of heterochromatin is essential for maintaining genome integrity and regulating gene expression, heterochromatin can also spread into neighboring regions in a sequence-independent manner, leading to the inactivation of genes. Because the distance of heterochromatin spreading is stochastic, the formation of boundaries, which block the spreading of heterochromatin, is critical for maintaining stable gene expression patterns. Here we review the current understanding of the mechanisms underlying heterochromatin spreading and boundary formation.     

Cramer法则在分式不等式证明中的应用

运用Cramer法则的工具,解决了一类分式不等式的证明问题,把数学知识进行高初的有机结合是对数学创新的一个重要目的.     

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

The rat neu gene, which encodes a protein closely related to the epidermal growth factor receptor, is a proto-oncogene that can be converted into an oncogene by a point mutation. Both genes encode proteins with a relative molecular mass of 185,000 but the question of why the neu gene product, p185neu, is oncogenic, whereas the product of c-neu, p185c-neu, is not, remains unanswered. The proteins have several features common to the family of tyrosine kinase growth-factor receptors, including cysteine-rich external domains, a hydrophobic transmembrane region and a cytoplasmic tyrosine kinase domain. The oncogenic p185neu differs from p185c-neu by an amino-acid substitution in the transmembrane region of the glycoprotein: this replacement of valine by glutamic acid at position 664 induces increased intrinsic tyrosine kinase activity which is associated with transformation. Many glycoproteins with charged amino acids in the transmembrane region exist as multimeric complexes at the plasma membrane. We have therefore investigated the association state of both products of the neu gene and show that the oncoprotein p185neu is organized at the plasma membrane primarily in an aggregated form, but that p185c-neu is not. Induction of an aggregated state may mimic aspects of ligand-induced receptor aggregation resulting in enzymatic activation that leads to cellular transformation.     

从国际货币体系改革趋势看中国金融发展战略

经过金融危机的冲击后,如何改革现有的国际货币体系成为国际金融界关注的重要课题,不同的经济体从各自的利益出发,提出了不同的改革意见和建议。从国际货币体系所主要包含的储备货币体系、国际收支平衡调节和国际资本流动等视角看,这些改革的设想从不同角度分析了现有的国际货币体系改革的潜在趋势。中国应当根据这些新的趋势,设定新的国际环境下的金融发展战略。     

对我校图书馆创建服务品牌的思考

高校图书馆服务品牌是在以自身资源服务过程中所形成的具有影响力的优质服务规范,创建高校图书馆服务品牌的主要目的是提升图书馆的服务质量,本文通过对高校图书馆服务品牌建设的思考,分析探讨了青海师范大学图书馆创建服务品牌的意义,提出了创建服务品牌的具体途径以及需要处理好的几个关系.     

基于时间序列的灰色预测技术在估产模型中的应用

在建立估产模型过程中，引进基于时间序列的灰色预测技术，通过对样本点建立基于时间序列的灰色预测模型和常规的多元线性回归气象模型的分析比较，试图找到一种计算简单，数据要求少而精度较高，时效性较好的建模方法，为时间序列预测在农作物估产方面的应用作出一点探索。     

江苏省优秀射箭运动员年龄结构特征分析

采用问卷调查、文献资料等方法,以江苏省射箭教练员、运动员作为调查对象,对其始训年龄、实际训练年限、出成绩的年龄段的特点和规律等问题进行调查分析,以全面了解射箭训练适应原理及与早期基础训练的关系,为青少年早期训练提供参考与建议.