Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity.     

基于动态贝叶斯网的时变样本空间无监督学习

提出了针对概率分布参数时变的样本空间的参数估计问题,由于一般的聚类和EM算法等参数估计方法是针对概率分布时不变的样本空间的问题所采用的。因此,对于概率分布时变的样本空间而言,这些方法均不能有效、准确地估计实时变化的样本参数。通过构建动态贝叶斯网,利用先验和后验的知识进行预测和滤波,结合贝叶斯增量式学习方法并充分利用了其学习所获得的样本空间概率模型变化演进的规律,这样可以较准确、平滑地学习实时概率模型及其分布参数。     

规模化经营对粮食生产的影响研究——基于空间计量模型的实证检验

土地规模化经营能否提高粮食生产效率,一直是学界争论的焦点.该研究基于2006年—2018年中国内地的省级面板数据,运用空间计量模型研究户均粮食播种面积对粮食单产的影响.研究发现,户均粮食播种面积和粮食单产均具有显著的空间自相关性,呈现出"高—高"型和"低—低"型集聚的特征;户均粮食播种面积对粮食单产具有显著影响,呈"U...     

交流永磁同步伺服系统仿真

在分析矢量控制原理的基础上,利用MATLAB/SIMULINK设计了交流永磁同步伺服系统的仿真模型,进行仿真研究。仿真结果验证了该仿真模型的有效性。     

基于遗传算法的船舶分段运输调度方法

为解决船厂平板运输车搬运船舶分段的日程计划问题,建立了利用最少数量的平板运输车完成分段搬运作业,以及所有分段搬运作业完成时间最小化的两阶段优化模型,提出了基于遗传算法的2种启发式方法以实现模型求解,并用数值实验的方法进行验证.结果表明,所提出的2种方法都能够较好地完成船舶分段运输调度计划,并实现平板运输车的高效利用.     

Lushan M_S7.0 earthquake:A blind reserve-fault event

In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas.     

专题学习网站的探索与思考

随着信息技术的发展,主题学习网站的建设正在全国如火如荼地展开,人们认识到这是一个融合学科教学、信息技术和研究性学习的良好平台.专题学习网站作为一种新型的网络教学资源,必将推进信息技术与各学科教学的整合.本文从构建专题学习网站实践层面对专题学习网站建设存在的问题、主题学习网站的建设要求和策略做了阐述.     

TPU/POE共混体系相分离过程的ATR-FTIR研究

探讨了一种新的共混体系热塑性聚氨酯(TPU)/聚乙烯-辛烯共聚物(POE)共混体系,在相分离过程中衰减全反射傅里叶变换红外光谱(ATR-FTIR),结果发现:对于不相容TPU/POE体系,随着热老化时间的增加,ATR-FT-IR特征峰面积也逐渐增加(温度较低除外),温度较高时则先增加后降低;而PU/POE/POE-g-...     

钢筋混凝土连续梁结构非弹性内力分析

本文在试验研究的基础上分析了纲筋混凝土连续梁结构内力的非弹性特性,并指出目前国际上的两种极限设计法,即“部分极限设计法”和“完全极限设计法”所存在的问题。文中把纲筋混凝土连续梁内力发展的全过程归结为三个不同性质的阶段。第二个阶段,也即因裂矮而引起内力的非弹性重分布,是非弹性分析中的一个重要环节,可按建议的“虚梁法”进行简便计算,按照试验资料还分析了传统线弹性方法的误差。对完全非弹性分析所需的两个关键荷载——开裂荷载和塑性铰荷载的计算方法也进行了分析。