康熙己卯顺天乡试案考辨

康熙三十八年发生的己卯顺天乡试案,是康熙朝科场大案之一,不仅牵涉甚广,而且对此后的科举制度发展产生了深远影响.文章主要考察了己卯顺天乡试案的案情始末,并对整个案件的处理情况进行了分析,指出此次科场案件不仅体现了康熙皇帝高明的政治手段和治国策略,更成为清朝科举制度改革的重要契机,由此而生发的各种科场改革对有清一代亦发挥重要作用.     

冀东金矿集中区控矿条件探讨

论述了冀东金矿集中区绿岩型金矿的矿质来源，并恢复其矿源层的原岩。对构造及中小型岩浆任入体的控矿作用作了论述，并提出了成矿模式。     

Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.

The inherited osteolyses or 'vanishing bone' syndromes are a group of rare disorders of unknown etiology characterized by destruction and resorption of affected bones. The multicentric osteolyses are notable for interphalangeal joint erosions that mimic severe juvenile rheumatoid arthritis (OMIMs 166300, 259600, 259610 and 277950). We recently described an autosomal recessive form of multicentric osteolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies in a number of consanguineous Saudi Arabian families. We localized the disease gene to 16q12-21 by using members of these families for a genome-wide search for homozygous-by-descent microsatellite markers. Haplotype analysis narrowed the critical region to a 1.2-cM region that spans the gene encoding MMP-2 (gelatinase A, collagenase type IV; (ref. 3). We detected no MMP2 enzymatic activity in the serum or fibroblasts of affected family members. We identified two family-specific homoallelic MMP2 mutations: R101H and Y244X. The nonsense mutation effects a deletion of the substrate-binding and catalytic sites and the fibronectin type II-like and hemopexin/TIMP2 binding domains. Based on molecular modeling, the missense mutation disrupts hydrogen bond formation within the highly conserved prodomain adjacent to the catalytic zinc ion.     

Algorithmic compression of empirical data: reply to Twardy, Gardner, and Dowe

This discussion note responds to objections by Twardy, Gardner, and Dowe to my earlier claim that empirical data sets are algorithmically incompressible. Twardy, Gardner, and Dowe hold that many empirical data sets are compressible by Minimum Message Length technique and offer this as evidence that these data sets are algorithmically compressible. I reply that the compression achieved by Minimum Message Length technique is different from algorithmic compression. I conclude that Twardy, Gardner, and Dowe fail to establish that empirical data sets are algorithmically compressible.     

对"晨光"体育活动的审度与思考

在总结河南省“晨光”体育活动成功经验的基础上 ,对提高学校体育的水平与质量进行了理论性论证 ,进而提出了“晨光”体育活动应推广与普及的合理化建议及可行性措施 .