创新:现代编辑传播的核心——读《编辑创新与现代传播》

创新是知识经济时代对现代编辑传播的核心要求.《编辑创新与现代传播》对这一命题做了四个方面的重要诠释:创新思维乃基础、创新能力为根本、理论创新应先行、实践创新是目的,从而以创新为理论圆点,构建了现代编辑主体的自我超越与发展之途,为编辑主体行为实践提供了具有活性的生命因子.     

Act in contravention: a non-planar coupled electrode design utilizing "tip effect" for ultra-high areal capacity,long cycle life zinc-based batteries

Aqueous zinc-based batteries (ZBBs) have great potential as commercial energy storage devices.However,the poor cycling stability of zinc anode under high areal ...     

铝箔碎屑收集负压管仿真优化设计

针对铝箔剪切机的碎屑收集问题,该文研究基于计算流体力学(CFD)使用负压管收集方法。在分析流场压力-速度耦合分布特征的基础上,探讨了不同管路结构对双支管吸力的影响规律,并给出管路优化设计建议。仿真结果表明：设置2个挡板时,第2个支管可形成有效负压及吸力,但在第1个支管附近会形成较大的低速回流区,气流流出支管;当2个支管共用1个出口时,2个支管均可产生负压及吸力,但支管与出口距离不一致时会导致支管速度差异达72.17%;优化后的等距型管路结构的支管速度差异降低至约2%,可在支管口形成均匀吸力,满足工业需求;随着挡板高度增加,支管口速度值、支管口速度差异分别呈现增大、减小趋势;支管与主管倒角设置对气流有良好的导向作用,支管速度可提高约9.64%。     

Cystic fibrosis transmembrane conductance regulator—emerging regulator of cancer

Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis, the most common life-limiting recessive genetic disease among Caucasians. CFTR mutations have also been linked to increased risk of various cancers but remained controversial for a long time. Recent studies have begun to reveal that CFTR is not merely an ion channel but also an important regulator of cancer development and progression with multiple signaling pathways identified. In this review, we will first present clinical findings showing the correlation of genetic mutations or aberrant expression of CFTR with cancer incidence in multiple cancers. We will then focus on the roles of CFTR in fundamental cellular processes including transformation, survival, proliferation, migration, invasion and epithelial–mesenchymal transition in cancer cells, highlighting the signaling pathways involved. Finally, the association of CFTR expression levels with patient prognosis, and the potential of CFTR as a cancer prognosis indicator in human malignancies will be discussed.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

中等专业学校加强档案工作建设刍议

作为纪录历史的档案文献,是党和国家的宝贵财富。学校档案工作是我国教育事业的重要组成部分,对学校教育教学管理和国家经济建设有着及其重要的作用。文章从梳理学校档案工作的概念和作用入手,对中等专业学校档案工作存在问题进行分析,提出一些加强这项工作的措施,以求科学、规范地做好中等专业学校档案工作。     

汽轮机通流部分清洗技术在6MW机组中的应用

通过对霍州煤电煤矸石热电厂2#汽轮机组推力瓦温度高原因分析,得出其主要原因为通流部分结垢严重,流通不畅,导致汽轮机做功能力下降,使机组无法带至额定负荷;并对通流部分结垢的原因进行分析、研究,作出清洗处理,有效降低了机组运行中的推力瓦温度,以提高机组的安全经济性。     

高超声速飞行器输入受限模糊反演控制

针对吸气式高超声速飞行器控制中存在的执行机构受限问题,提出一种模糊反演控制设计策略。设计一种新的辅助系统分别对跟踪误差和控制律进行补偿,在物理执行机构受限时能够同时保证闭环系统及跟踪误差的有界性。在反演控制的设计框架下,引入模糊控制器逼近模型中的不确定项,提高控制系统的鲁棒性。为防止出现传统反演方法中存在的“微分膨胀”问题,引入滑模微分器对虚拟导数进行求解。最后,通过实例仿真验证所设计控制策略的有效性。     

Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14⁺ monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)⁺ multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated activating phosphorylations of signaling molecules in monocytes that are critical for OC development. These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB. IL-33 also enhanced expression of OC differentiation factors including TNF-α receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells cytoplasmic 1, c-Fos, c-Src, cathepsin K, and calcitonin receptor. IL-33 eventually induced bone resorption. This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14⁺ monocytes.