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161.
Driving involves long hours of physical work within c onfined compartment. Taxi drivers usually work with prolonged working hours, add itional stress may likely be induced on particular body limbs. Occupational heal th may occur and working efficiency may potentially be affected resulting fr om fatigues, pains or diseases. These problems, however, could be remedied if mo re attention is paid on seating design, the workplace and driving postures adopt ed. Ergonomics design can provide better understanding... 相似文献
162.
Summary 2 populations of cells were found in the Deiters' nucleus responsive to direct electrical stimulation of the ipsilateral saccule. Only those Deiters' neurons activated monosynaptically from the saccule could be driven antidromically from the oculomotor nucleus. Such an intracellular study provides strong evidence for a tri-neuronal arc in the sacculo-ocular reflex for vertical eye movements.Acknowledgment. This study was supported by the Medical Faculty Research Grant No. 377/004/03, University of Hong Kong. 相似文献
163.
Z Ma S W Morris V Valentine M Li J A Herbrick X Cui D Bouman Y Li P K Mehta D Nizetic Y Kaneko G C Chan L C Chan J Squire S W Scherer J K Hitzler 《Nature genetics》2001,28(3):220-221
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain. 相似文献
164.
Structural uniqueness of lactose operator 总被引:8,自引:0,他引:8
165.
A search for insect growth inhibitors in methanol extracts of soybean leaves resulted in isolation of pinitol. Pinitol caused a 50% reduction in weight gain (ED50) of Heliothis zea larvae at about 0.7% when added to a synthetic diet. Although myo-inositol is a normal component of the insect diet, it also caused growth inhibition at higher concentrations; ED50 4%. 相似文献
166.
González-Maeso J Ang RL Yuen T Chan P Weisstaub NV López-Giménez JF Zhou M Okawa Y Callado LF Milligan G Gingrich JA Filizola M Meana JJ Sealfon SC 《Nature》2008,452(7183):93-97
The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by their high affinity for serotonin 5-HT2A receptors (2AR). Drugs that interact with metabotropic glutamate receptors (mGluR) also have potential for the treatment of schizophrenia. The effects of hallucinogenic drugs, such as psilocybin and lysergic acid diethylamide, require the 2AR and resemble some of the core symptoms of schizophrenia. Here we show that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex. The 2AR-mGluR2 complex triggers unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolishes hallucinogen-specific signalling and behavioural responses. In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis. These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis. 相似文献
167.
GPS接收机中相位舍位噪声影响DDL的跟踪性能 总被引:1,自引:0,他引:1
为了解决在全球卫星定位系统(GPS)接收机中出现的阶梯状伪距测量结果的问题,在分析了接收机中伪码跟踪原理的基础上,找到了造成该问题的原因.通过研究数控振荡器(NCO)中相位舍位噪声的规律,得到了该噪声与数字中频采样率的关系,提出了基于减小相位舍位噪声的中频采样率优化方案.仿真结果显示: 选择高于且接近伪码速率整数倍的中频采样率能明显的抑止NCO相位舍位噪声.优选出的高分辨率、低漂移的数字中频采样率可以有效提高GPS接收机的跟踪精度. 相似文献
168.
研究了裂纹面内均匀载荷作用下的正交各向异性复合材料板周期平行裂纹尖端场问题。利用复变函数方法,将力学问题化为偏微分方程边值问题。根据叠加原理,将偏微分方程边值问题化为Ⅰ型和Ⅱ型两个边值问题求解。在复数域内,利用双曲函数的周期性,通过构造适当的Westergaard应力函数,将周期平行裂纹尖端场问题化为单一裂纹尖端场问题。得到混合型周期平行裂纹尖端附近的应力强度因子和应力场的解析表达式。由于平行裂纹的周期性分布,应力强度因子的大小取决于形状因子。所得结果表明,当裂纹间距趋于无穷大时,应力强度因子退化为含单个中心裂纹时的结果,并且所得到的解析解更好的体现了平行裂纹分布的周期性。研究结果为结构和材料的强度设计提供了有意义的参考。 相似文献
169.
Gudbjartsson DF Arnar DO Helgadottir A Gretarsdottir S Holm H Sigurdsson A Jonasdottir A Baker A Thorleifsson G Kristjansson K Palsson A Blondal T Sulem P Backman VM Hardarson GA Palsdottir E Helgason A Sigurjonsdottir R Sverrisson JT Kostulas K Ng MC Baum L So WY Wong KS Chan JC Furie KL Greenberg SM Sale M Kelly P MacRae CA Smith EE Rosand J Hillert J Ma RC Ellinor PT Thorgeirsson G Gulcher JR Kong A Thorsteinsdottir U Stefansson K 《Nature》2007,448(7151):353-357
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated with familial AF but account for only a small fraction of all cases of AF. We have performed a genome-wide association scan, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and find a strong association between two sequence variants on chromosome 4q25 and AF. Here we show that about 35% of individuals of European descent have at least one of the variants and that the risk of AF increases by 1.72 and 1.39 per copy. The association with the stronger variant is replicated in the Chinese population, where it is carried by 75% of individuals and the risk of AF is increased by 1.42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart. 相似文献
170.
Prevalence of allergic rhinitis has rapidly increased among Chinese children,but the reasons are unclear.Recent findings have suggested that exposure to outdoor air pollutants may increase the risk of allergic rhinitis,but the results were inconsistent.This study further investigated the effect of outdoor air pollutants on allergic rhinitis among preschool children.A standardized questionnaire on health,home and environmental factors was conducted for 4988 children aged 1–8 in the city of Changsha,and the concentrations of PM10(particle diameter 10 m),sulfur dioxide(SO2)and nitrogen dioxide(NO2)during 2006–2011 were acquired from the official web of Changsha Environmental Protection Agency.Results showed that the prevalence of children’s doctor diagnosed rhinitis was 8.4%(95%confidence interval[CI]7.0%–10.0%).It was found that the prevalence of rhinitis was not associated with site-specific background concentrations of air pollutants,but significantly positively correlated with age-related accumulative personal exposure of PM10,SO2and NO2.We conclude that age-related accumulative personal exposure to ambient air pollution may play an important role in the development of rhinitis. 相似文献