BOG初次免疫联合结核分枝杆菌Ag85A DNA疫苗加强免疫效果的研究

为探讨BCG初次免疫,结核分枝杆菌Ag85A DNA疫苗加强免疫的序贯免疫策略对小鼠的免疫效果。采用BCG及结核分枝杆菌Ag85A DNA疫苗依次免疫小鼠,在末次免疫后的4、6、8周通过检测小鼠血清总IgG抗体、特异性淋巴细胞增殖．细胞因子的水平,观测BCG初次免疫,Ag85A DNA疫苗加强免疫的策略对小鼠的免疫效果。结果显示,采用BCG初次免疫,结核分枝杆菌Ag85A DNA疫苗加强免疫的策略组的小鼠与其它免疫方式组相比,IgG明显升高（P〈0．05）、特异性淋巴细胞明显增殖、IFN7、IL-2、IL-4水平明显增高（P〈0．05）。由此可知,在采用BCG初次免疫,结核分枝杆菌Ag85A DNA疫苗加强的免疫策略后,能增强对小鼠的免疫效应,尤其是Thl型细胞免疫反应增强明显,为进一步在动物体内进行保护性效应试验的研究提供了实验依据。     

Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China

Prevalence of allergic rhinitis has rapidly increased among Chinese children,but the reasons are unclear.Recent findings have suggested that exposure to outdoor air pollutants may increase the risk of allergic rhinitis,but the results were inconsistent.This study further investigated the effect of outdoor air pollutants on allergic rhinitis among preschool children.A standardized questionnaire on health,home and environmental factors was conducted for 4988 children aged 1–8 in the city of Changsha,and the concentrations of PM10(particle diameter 10 m),sulfur dioxide(SO2)and nitrogen dioxide(NO2)during 2006–2011 were acquired from the official web of Changsha Environmental Protection Agency.Results showed that the prevalence of children’s doctor diagnosed rhinitis was 8.4%(95%confidence interval[CI]7.0%–10.0%).It was found that the prevalence of rhinitis was not associated with site-specific background concentrations of air pollutants,but significantly positively correlated with age-related accumulative personal exposure of PM10,SO2and NO2.We conclude that age-related accumulative personal exposure to ambient air pollution may play an important role in the development of rhinitis.     

半群的广义Ω-模糊双理想

给定一个集合Ω,引入半群的广义Ω-模糊双理想概念,讨论了它的一些相关性质及等价刻画,研究了半群的广义Ω-模糊双理想的同态像与原像的性质。此外,通过在SΩ上定义运算得到半群(SΩ,),并研究了其双理想与广义Ω-模糊双理想。     

扩张李代数Schrödinger-Virasoro子代数生成元和一些李子代数幂零性

研究了扩张无限维李代数Schr?dinger-Virasoro子代数的生成元.证明了李子代数h2与商李代数h5/h2都无有限生成元,李代数Schr?dinger-Virasoro有有限生成元且生成元可为5.最后证明了李子代数h5为幂零子代数.     

碱金属阳离子对手性硼磷酸铜锂化合物LiCu_2[BP_2O_8(OH)_2]晶化的影响

采用硼酸熔融法研究对映体过量的开放骨架硼磷酸铜锂化合物LiCu_2[BP_2O_8(OH)_2]的合成条件,并用Na和K源取代Li源合成该手性化合物.实验结果表明:水和Li~+是生成该手性化合物的关键因素,水过量会使Li~+无法参与晶化,少量的水会促进目标产物形成大单晶;Na~+不能取代Li~+合成该化合物,K~+仅可部分取代Li~+合成该化合物,所得产物均发生对称性破缺.     

昆虫内生真菌Chaetomium globosum ZWC5的分离鉴定及其抗癌活性代谢产物的研究

为了研究中华稻蝗内生真菌ZWC5菌株及其活性代谢产物,通过菌株形态和其r DNA的ITS序列分析,鉴定其为球毛壳霉(Chaetomium globosum);采用MTT法和流式细胞技术测定其代谢产物的抗癌活性,结果表明其石油醚提取物对肝癌细胞HepG2和SMMC-7721的IC50分别为22.1 mg/L,33.8 mg/L,可诱导HepG2细胞凋亡,而对正常肝细胞LO-2未显示明显的细胞毒性;GC-MS检测分析显示其醚提物主要含12种化学成分.     

Temperature distribution study during the friction stir welding process of Al2024-T3 aluminum alloy

Heat flux characteristics are critical to good quality welding obtained in the important engineering alloy Al2024-T3 by the friction stir welding (FSW) process. In the present study, thermocouples in three different configurations were affixed on the welding samples to measure the temperatures: in the first configuration, four thermocouples were placed at equivalent positions along one side of the welding direction; the second configuration involved two equivalent thermocouple locations on either side of the welding path; while the third configuration had all the thermocouples on one side of the layout but with unequal gaps from the welding line. A three-dimensional, non-linear ANSYS computational model, based on an approach applied to Al2024-T3 for the first time, was used to simulate the welding temperature profiles obtained experimentally. The experimental thermal profiles on the whole were found to be in agreement with those calculated by the ANSYS model. The broad agreement between the two kinds of profiles validates the basis for derivation of the simulation model and provides an approach for the FSW simulation in Al2024-T3 and is potentially more useful than models derived previously.     

松嫩草原碱化草甸朝鲜碱茅光合生理生态特性的研究

在松嫩平原碱化草甸生长季中期,朝鲜碱茅不同龄级叶片净光合速率的日变化均为双峰曲线,第一个峰值出现在12:00左右,第二峰值出现在17:00左右;各龄级叶片中以4 a叶片的净光合速率最高,5 a叶片次之,3 a叶片最低.朝鲜碱茅为C3植物,光补偿点为56 μmol/ (m2·s),光饱和点为1 800 μmol/ (m2 ·s),光半饱和点为600 μmol/ (m2·s),光近饱和点为1 500 μmol/ (m2·s).     

扩充修正程序的一些基本结果

文献[4,5]为修正程序提出了一种包含经典否定的扩充,其关键特征在于能够区分“没有知识”和“具有否定的知识”,即区别“不知道”和“知道为否”。在这篇文章中,除了为该扩充修正程序提出了计算其合法修正的算法外,更重要的是,还研究了它的一些基本特征。这些特征形式化地表明了扩充修正程序的本质。     

盐碱胁迫对羊草可溶性蛋白质含量的影响

利用盆栽实验,对幼苗期灰绿和黄绿两个生态型羊草用NaCl和Na2CO3进行胁迫后,采用紫外分光光度法对可溶性蛋白含量进行了测定.定量分析结果表明,在不同浓度NaCl和Na2CO3胁迫条件下,灰绿型和黄绿型羊草可溶性蛋白质含量分别是对照的2.52～3.52倍,4.87～10.32倍,1.60～3.58倍和1.95～6.67倍.灰绿型和黄绿型羊草可溶性蛋白质含量在NaCl浓度为100 mmol/L和25 mmol/L,Na2CO3浓度为100 mmol/L和50 mmol/L时达到最高值.由此表明,灰绿型和黄绿型羊草具有一定的耐盐碱能力,且灰绿型羊草的耐盐碱能力高于黄绿型羊.