论章学诚的文书档案体式观

章学诚是清代著名的文史学家。《文史通义》为其代表作。其中有许多篇目提到文书档案的体式。文书档案的体式是指文书档案的体裁格式。章学诚关于文书档案的体式的观点,总的来看可分为体式的规范要求与行文、称谓、格式与成文方式等多个方面。通过对文书档案体式的梳理,可再现当时文书档案的原生态,使现代人明白文书档案的传承与其发展过程中的不足之处,从而使人明白古为今用的道理。     

利用张力样条模拟定向井井眼轨迹的方法研究

根据张力样条的特性及定向井井眼轨迹的形成规律,提出了用张力样条模拟定向井井眼轨迹的方法.详细介绍了用张力样条法确定定向井井眼轨迹的步骤.利用这种方法可以计算定向井任一点的空间位置.实例计算结果表明,在已知任意个相邻测点之间,用张力样条插值计算未知测点的井斜角和方位角,与实测值相比,误差很小,满足实际井眼轨迹计算的要求,具有实用价值,为定向井井眼轨迹的计算提供了一种新的方法.     

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.

14-3-3Sigma is a member of a family of proteins that regulate cellular activity by binding and sequestering phosphorylated proteins. It has been suggested that 14-3-3sigma promotes pre-mitotic cell-cycle arrest following DNA damage, and that its expression can be controlled by the p53 tumour suppressor gene. Here we describe an improved approach to the generation of human somatic-cell knockouts, which we have used to generate human colorectal cancer cells in which both 14-3-3sigma alleles are inactivated. After DNA damage, these cells initially arrested in the G2 phase of the cell cycle, but, unlike cells containing 14-3-3sigma, the 14-3-3sigma-/- cells were unable to maintain cell-cycle arrest. The 14-3-3sigma-/- cells died ('mitotic catastrophe') as they entered mitosis. This process was associated with a failure of the 14-3-3sigma-deficient cells to sequester the proteins (cyclin B1 and cdc2) that initiate mitosis and prevent them from entering the nucleus. These results may indicate a mechanism for maintaining the G2 checkpoint and preventing mitotic death.     

关于中小学数学课程改革的几点思考

本文阐述了实施素质教育对数学教材改革的必要性、迫切性 ,提出了数学课程内容现代化、结构层次化、表述过程化三个方面进行改革的构想。     

海洋声图像——用于研究和监测

海洋声学是一个重要的研究领域，它为海底及其水下形态和过程的勘探提供了必不可少的工具。本书收录了来自22个国家的120名海洋专家提供的400幅声图像，展现了一个应用于海洋声图像的全面概要。本书综合了地球物理学的多个研究领域，包括海滨工业及经济活动、全国监视以及海洋和大陆架的保护等。本书在展示由图像揭示的复杂关联的同时，还配有简明的文字解释，将复杂的结果浓缩为精华的信息，以便让不同领域的专家都能够清晰地理解。这本地图集跨学科地阐释了水下声学及其详细描绘水下世界的卓越能力。     

In Situ XRD and XAS Investigation of Cathode Materials in Li-ion Battery

1 Results Lithium ion batteries have been widely used in modern portable electronics,such as cellular phones and notebook computers,because of their low cost,long life,and high energy density.In the lithium ion batteries,the cathode provides lithium ion source and plays a critical role to determinate the performance of battery.Lithium transition metal oxides have been investigated as active cathode materials due to their high potential versus Li/Li and large proportion of the lithium ions can be insert...     

L(-)对甲苯磺酰乳酸乙酯的合成及催化剂研究

本文采用三乙胺催化剂合成了高效除草剂的合成单体——L（一）对甲苯磺酰乳酸乙酯，产率为96％，取得了较好的合成效果，分析测定了产物的旋光度，确定其纯度高达96％，表明三乙胺是一种高活性的催化剂。     

改性聚丙烯裁切板专用料的研制

为了改进聚丙烯(PP)的低温韧性,本研究采用弹性体对PP进行了共混改性,考察了共混体系各组分含量的变化对共混物硬度、冲击强度和拉伸强度的影响,确定出制得裁切板专用料的最佳配方.研究结果表明:当wPP∶w共聚PP∶w弹性体∶wPE为某一适当比时,制得的共混料完全可以满足裁切板性能的要求.     

Structure-activity relationship of endomorphins and their analogs

To study the structure-activity relationship of endomorphins (EMs), the action of opioid receptor binding (AORB), analgesic activity and vasodilator effects of EMs and their eight analogs were investigated, which were prepared by rationally replacing the 2-/3-amino acid (Aa) of EMs. The results showed: (ⅰ) The 2-Aa was comparatively more related to the selectivity of EMs while the 3-Aa to their affinity; (ⅱ) the analgesia and vasodilatation of EMs and their analogs were not completely dictated by their AORB (in vitro), the action of [D-Pro²]EM-2 was unusual; (ⅲ) EMs lost their analgesia in the central nervous system and their vasodilatation in the circulatory system with different mechanisms; the former was due to the degradation of some peptidase, and the latter possibly due to the feedback inhibition.