Vaccination against and treatment of tuberculosis, the leishmaniases and AIDS: perspectives from basic immunology and immunity to chronic intracellular infections

The occurrence of infectious disease represents a failure of the immune system, a failure that must be prevented by effective vaccination or remedied by treatment. Vaccination against acute diseases such as smallpox and polio are very effective, due to the rapid and increased immune response of vaccinated individuals upon natural infection. In contrast, effective vaccination against intracellular pathogens that cause chronic diseases, such as the leishmaniases, tuberculosis and AIDS, has not been achieved. Clinical observations suggest cell-mediated, Th1 responses, exclusive of antibody production and the generation of Th2 cells, are optimally protective against these intracellular pathogens. Effective vaccination must ensure the generation of such a protective response. We explore here whether understanding very broad features of the regulation of the immune response can accommodate modern findings on the immunological features of these diseases, and provide a perspective within which strategies for effective vaccination and treatment can be developed.     

南昌滕王阁明清庾楼群汇考——江右史话批判之四

本文通过地毯式发掘、排比明、清江右省、府、州、县、厅<官志>"省会水次漕仓"原始档案,系统还原明、清两代五个半世纪间.南昌章江水次五十余县邸阁漕仓"望江楼"群密集汇聚历史原貌;率先揭举明景泰三年又嘉靖六年江右官宪挪移高安等县废仓直接改筑滕王阁之滕学建筑秘史;并深刻揭示汉晋邸阁隋唐转型运动虽降至明、清,仍不断重复其农业文明仓储文化遗传基因漕仓邸阁/名胜楼阁/会馆公寓等社会政治、经济、文化三重复合身份循环转换的生命轮回模式;全面辩证洪州滕王阁原生态邸阁历史文化圈自然、人文、经济地理学核心价值;穿透封建史学迷雾与江右史话泡沫,复原千古名楼滕王阁庐山真面目.     

鼓励学生大胆猜想

猜想就是猜测,在探索性的思考中,几乎少不了猜想的成份.鼓励学生大胆猜想,可以打开思路、活跃思维,锻炼学生的想象力;思考、探索推理、判断能力.     

A Burgessian Critique of Nominalistic Tendencies in Contemporary Mathematics and its Historiography

We analyze the developments in mathematical rigor from the viewpoint of a Burgessian critique of nominalistic reconstructions. We apply such a critique to the reconstruction of infinitesimal analysis accomplished through the efforts of Cantor, Dedekind, and Weierstrass; to the reconstruction of Cauchy’s foundational work associated with the work of Boyer and Grabiner; and to Bishop’s constructivist reconstruction of classical analysis. We examine the effects of a nominalist disposition on historiography, teaching, and research.     

PbO过量对大各向异性改性PbTiO_3性能的影响

研究了一种新型的具有大各向异性的改性PbTiO3 陶瓷材料的性能随着材料制备中铅过量的变化而变化的关系 ,其中包括材料的机电耦合系数、机械品质因素、介电损耗等 .研究结果表明当铅过量为 1%～ 2 % (摩尔百分比 )时 ,材料的性能达到较佳 .通过分析认为 :当铅不足时 ,主要是由其它的B位掺杂离子取代A位的铅 ,从而造成配方B位离子的重新排列 ,材料的性能因而有所下降 ;当铅过量时 ,铅离子将取代A位的钙 ,部分钙离子将进入晶界 ,从而降低了材料的性能     

外腔法压窄半导体激光器线宽的二阶理论

对耦合于长无源外腔的半导体激光器的线宽行为进行了二阶理论分析，首次得到了 外腔半导体激光器的线宽压窄率随外腔长的增加而出现饱和的结论。并给出了饱和因子 的表述式。     

地中海伞藻(Acetabularia mediterranea)叶绿体DNA串联重复顺序的克隆和限制性内切酶图谱分析

以COS质粒(cosmid)pCOS 2EMBL 为载体,构建了地中海伞藻叶绿体基因组分子克隆库,并且筛选到含有串联重复顺序的克隆。经限制性内切酶酶解图谱分析,证明了串联重复顺序的存在,重复次数为4次以上。     

Au（Ⅲ）（H,Na）Cl／伯胺N1923体系活度问题探讨

本文通过考察萃取剂浓度、氯离子浓度以及体系温度等因素对伯胺N_(1923)萃取Au(Ⅲ)的影响,导出了N_(1923)的活度系数与浓度的关系式,测定并计算出该反应的热力学平衡常数及热力学函数。     

香港室内氡水平及其与建筑物表面氡析出率的关系

本文报导用活性炭盒吸附方法对香港室内氡浓度的测量结果及其浓度分布规律。对室内氡浓度与建筑物表面氡析出率的关系进行了分析研究。证实室内空气中的氡主要来源于建材中的镭,而氡浓度水平只决定于室内建筑物表面氡的析出率及通风状况。