转基因生物对我们来说是好的么——人类学家对这场争论的贡献

转基因生物是有望带来巨大益处的新的生物体,同时也会带来诸多风险。人类学能够在看待转基因农作物和食品问题上提供重要的批判视角。为了对有关转基因生物的问题给出令人信服的回答,区分公共转基因生物和公司转基因生物十分必要,并且还必须坚持关注新技术的社会维度和政治维度。     

Artemisinins target the SERCA of Plasmodium falciparum

Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum. Artemisinins are sesquiterpene lactones widely used to treat multidrug-resistant malaria, a disease that annually claims 1 million lives. Despite extensive clinical and laboratory experience their molecular target is not yet identified. Activated artemisinins form adducts with a variety of biological macromolecules, including haem, translationally controlled tumour protein (TCTP) and other higher-molecular-weight proteins. Here we show that artemisinins, but not quinine or chloroquine, inhibit the SERCA orthologue (PfATP6) of Plasmodium falciparum in Xenopus oocytes with similar potency to thapsigargin (another sesquiterpene lactone and highly specific SERCA inhibitor). As predicted, thapsigargin also antagonizes the parasiticidal activity of artemisinin. Desoxyartemisinin lacks an endoperoxide bridge and is ineffective both as an inhibitor of PfATP6 and as an antimalarial. Chelation of iron by desferrioxamine abrogates the antiparasitic activity of artemisinins and correspondingly attenuates inhibition of PfATP6. Imaging of parasites with BODIPY-thapsigargin labels the cytosolic compartment and is competed by artemisinin. Fluorescent artemisinin labels parasites similarly and irreversibly in an Fe2+-dependent manner. These data provide compelling evidence that artemisinins act by inhibiting PfATP6 outside the food vacuole after activation by iron.     

GC/MS法追踪摇头丸杂质体系

本文运用GS/MS的总离子流法,选择离子法,对南京地区常见的几种摇头丸进行全面分析,找出与合成途径相关的痕量杂质,根据杂质情况初步确定其合成途径.     

Initial sequencing and comparative analysis of the mouse genome

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.     

2006-based national population projections for the U.K. and constituent countries

The 2006-based national population projections, carried out by the Office for National Statistics in consultation with the devolved administrations, show the population of the UK rising from 60.6 million in 2006, passing 65 million in 2016 and 70 million in 2028, to reach 71.1 million by 2031. In the longer-term, the projections suggest that the population will continue rising beyond 2031 for the full length of the projection period. The population will become older with the median age expected to rise from 39.0 years in 2006 to 41.8 years by 2031. Since the last projection round legislation has been passed to increase the state pension age from 65 to 66 for both sexes between 2024 and 2026. Despite this change, the number of people of working age for every person of state pensionable age will reduce from 3.32 in 2006 to 2.91 by 2031. The legislation includes further increases in the state pension age to 68 for both sexes by 2046.