Chronic hepatic injury following experimental viral hepatitis in the dog

Zusammenfassung 20 junge, nicht immune Beagle Hunde (Neutralisationstiter < 1/4) wurden mit 300 ID₅₀ (Gewebskultur) des Hepatitis-canis-Virus infiziert. Alle Tiere starben innerhalb von 4–6 Tagen an ausgedehnter Lebernekrose. Im Gegensatz dazu überlebten 16 partiell immune Tiere (Neutralisationstiter 1/4 bis 1/100) die akute Erkrankung. Im Verlaufe einer Überlebenszeit bis zu 8 Monaten entwickelte sich eine der menschlichen Hepatitis chronica ähnliche Lebererkrankung.     

Isolation of filaments of the chick lens

A preparation of intermediate filaments isolated from the chicken lens is enriched with a 50,000 dalton polypeptide.     

Design of Smart Polymer-Protein Conjugates and Smart Magnetic Nanoparticles for Use in Microfluidic Diagnostic Assays

1 Results In this talk,I will describe the design,synthesis and application of smart polymers for use in microfluidic diagnostic devices.We are synthesizing a variety of temperature- and pH-responsive polymers using RAFT living free radical polymerization techniques.This allows us to control molecular weight and to achieve a narrow MW distribution of the polymers. Furthermore,RAFT polymers have reactive end groups that are used to conjugate the polymers to proteins.We are also using those groups to bind...     

A hydrogen-based subsurface microbial community dominated by methanogens.

The search for extraterrestrial life may be facilitated if ecosystems can be found on Earth that exist under conditions analogous to those present on other planets or moons. It has been proposed, on the basis of geochemical and thermodynamic considerations, that geologically derived hydrogen might support subsurface microbial communities on Mars and Europa in which methanogens form the base of the ecosystem. Here we describe a unique subsurface microbial community in which hydrogen-consuming, methane-producing Archaea far outnumber the Bacteria. More than 90% of the 16S ribosomal DNA sequences recovered from hydrothermal waters circulating through deeply buried igneous rocks in Idaho are related to hydrogen-using methanogenic microorganisms. Geochemical characterization indicates that geothermal hydrogen, not organic carbon, is the primary energy source for this methanogen-dominated microbial community. These results demonstrate that hydrogen-based methanogenic communities do occur in Earth's subsurface, providing an analogue for possible subsurface microbial ecosystems on other planets.