Hemodynamic studies in acute venous stasis edema in rats

An increase in venous pressure in the rat tail is known to result in acute edema. Acute venous stasis edema of the rat tail was induced by applying a force-controlled banding of standard tension (200 g) proximally for a period of 6-12 h. The hemodynamic changes of acute venous stasis edema were evaluated using non-invasive plethysmography, fluorescence angiography, computer thermography and invasive radioactive microsphere techniques. It is shown here that reduction of tail circulation to 40% of the control value is followed by prolonged vascular disorder characterized by genesis of reversible edema, increased total blood flow to the tail and decreased local cutaneous blood flow, without affecting the general hemodynamics. The cutaneous circulation (decreased blood flow) seems to be principally involved in the edemogenic response, whereas the deeper vessels (hyperemia) may or may not play a determinant role in acute experimental venous stasis edema in rats.     

Determination of polyamine oxidase activities in human tissues

A very simple fluorometric assay for polyamine oxidase (PAO) in tissues, with N1-monoacetylspermine as substrate, is described. The PAO was present in all human organs tested; it was highest in the liver, followed by the testis, kidney, spleen and small intestine.     

Estrogen receptor in uteri of mice of different H-2 genotypes.

A relationship between the amount of available estradiol receptors in uteri of inbred mice and their H-2 genotype is suggested by study in congenic animals.     

(−)-Δ8-tetrahydrocannabinol: Two novel in vitro metabolites

Zusammenfassung (–)-⁸-Tetrahydrocannabinol ist einer der Aktivstoffe in Marihuana (Cannabis sativa L.). Inkubation dieser Verbindung mit der überstehenden Zentrifugationsfraktion (9000g) aus männlicher Hundeleber ergab zwei Hauptmetaboliten, welche durch Massenspektrometrie und Kernresonanzspektroskopie identifiziert wurden. Den beiden Verbindungen werden die Strukturen des 1-Hydroxy-⁸-tetrahydrocannabinols und des 3-Hydroxy-⁸-tetrahydrocannabinols zugeordnet.     

The antennae and mating behaviour ofDrosophila females

Summary The females ofDrosophila bipectinata andD. malerkotliana are able to discriminate between their own and alien males in the absence of antennae. Thus mate recognition seems to depend on contact chemoreceptors in these 2 species.We are grateful to the Head of the Department of Zoology, B.H.U. for providing the necessary facilities. Thanks are due to the U.G.C., New Delhi, India for awarding a junior research fellowship to O.P.S.     

l-DOPA treatment in Parkinson's disease: Effect on dopamine and related substances in discrete brain regions

Zusammenfassung Beil-DOPA behandelten Parkinsonpatienten wird gefunden, dass Dopamin und Homovanillinsäure besonders im Striatum akkumuliert wurden. Damit wird die Möglichkeit, dass Dopamin an der Antiparkinson-Wirkung desl-DOPA entscheidend beteiligt ist, in direkter Weise gestützt.