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41.
Raf-1 activates MAP kinase-kinase. 总被引:56,自引:0,他引:56
J M Kyriakis H App X F Zhang P Banerjee D L Brautigan U R Rapp J Avruch 《Nature》1992,358(6385):417-421
The normal cellular homologue of the acutely transforming oncogene v-raf is c-raf-1, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli. The physiological substrates of the protein c-Raf-1 are unknown. The mitogen-activated protein (MAP) kinases Erk1 and 2 are also activated by mitogens through phosphorylation of Erk tyrosine and threonine residues catalysed by a protein kinase of relative molecular mass 50,000, MAP kinase-kinase (MAPK-K). Here we report that MAPK-K as well as Erk1 and 2 are constitutively active in v-raf-transformed cells. MAPK-K partially purified from v-raf-transformed cells or from mitogen-treated cells can be deactivated by phosphatase 2A. c-Raf-1 purified after mitogen stimulation can reactivate the phosphatase 2A-inactivated MAPK-K over 30-fold in vitro. c-Raf-1 reactivation of MAPK-K coincides with the selective phosphorylation at serine/threonine residues of a polypeptide with M(r) 50,000 which coelutes precisely on cation-exchange chromatography with the MAPK-K activatable by c-Raf-1. These results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo. To our knowledge, MAPK-K is the first physiological substrate of the c-raf-1 protooncogene product to be identified. 相似文献
42.
Allosteric interactions in (Na+ plus K+)-ATPase 总被引:1,自引:0,他引:1
43.
Mungall AJ Palmer SA Sims SK Edwards CA Ashurst JL Wilming L Jones MC Horton R Hunt SE Scott CE Gilbert JG Clamp ME Bethel G Milne S Ainscough R Almeida JP Ambrose KD Andrews TD Ashwell RI Babbage AK Bagguley CL Bailey J Banerjee R Barker DJ Barlow KF Bates K Beare DM Beasley H Beasley O Bird CP Blakey S Bray-Allen S Brook J Brown AJ Brown JY Burford DC Burrill W Burton J Carder C Carter NP Chapman JC Clark SY Clark G Clee CM Clegg S Cobley V Collier RE Collins JE Colman LK Corby NR Coville GJ 《Nature》2003,425(6960):805-811
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45.
Michael J. Artis Anindya Banerjee Massimiliano Marcellino 《Journal of forecasting》2005,24(4):279-298
Data are now readily available for a very large number of macroeconomic variables that are potentially useful when forecasting. We argue that recent developments in the theory of dynamic factor models enable such large data sets to be summarized by relatively few estimated factors, which can then be used to improve forecast accuracy. In this paper we construct a large macroeconomic data set for the UK, with about 80 variables, model it using a dynamic factor model, and compare the resulting forecasts with those from a set of standard time‐series models. We find that just six factors are sufficient to explain 50% of the variability of all the variables in the data set. These factors, which can be shown to be related to key variables in the economy, and their use leads to considerable improvements upon standard time‐series benchmarks in terms of forecasting performance. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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47.
Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis 总被引:8,自引:0,他引:8
D. Grunberger R. Banerjee K. Eisinger E. M. Oltz L. Efros M. Caldwell V. Estevez K. Nakanishi 《Cellular and molecular life sciences : CMLS》1988,44(3):230-232
Summary The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE. 相似文献
48.
Supratim Biswas Saikat Samanta Rajib Dey Siddhartha Mukherjee Pataki C. Banerjee 《矿物冶金与材料学报》2013,20(8):705-712
Leaching of nickel and cobalt from two physical grades (S1, 125–190 μm, coarser and S3, 53–75 μm, finer) of chromite overburden was achieved by treating the overburden (2% pulp density) with 21-d culture filtrate of an Aspergillus niger strain grown in sucrose medium. Metal dissolution increases with ore roasting at 600°C and decreasing particle size due to the alteration of microstructural properties involving the conversion of goethite to hematite and the increase in surface area and porosity as evident from X-ray diffraction (XRD), thermogravimetry-differential thermal analysis (DT-TGA), and field emission scanning electron microscopy (FESEM). About 65% Ni and 59% Co were recovered from the roasted S3 ore employing bioleaching against 26.87% Ni and 31.3% Co using an equivalent amount of synthetic oxalic acid under identical conditions. The results suggest that other fungal metabolites in the culture filtrate played a positive role in the bioleaching process, making it an efficient green approach in Ni and Co recovery from lateritic chromite overburden. 相似文献
49.
Solt LA Wang Y Banerjee S Hughes T Kojetin DJ Lundasen T Shin Y Liu J Cameron MD Noel R Yoo SH Takahashi JS Butler AA Kamenecka TM Burris TP 《Nature》2012,485(7396):62-68
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-ERB-β have an integral role in regulating the expression of core clock proteins driving rhythms in activity and metabolism. Here we describe the identification of potent synthetic REV-ERB agonists with in vivo activity. Administration of synthetic REV-ERB ligands alters circadian behaviour and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases. 相似文献
50.
S. K. Banerjee 《Cellular and molecular life sciences : CMLS》1973,29(6):713-714
Résumé Nous avons étudié l'effet d'une l'illumination continue ou d'une obscurité de 7 jours sur le système hypothalamique neurosécréteur (HNS) du lézard des jardinsCalotes versicolor. L'illumination a stimulé le HNS par activation de la synthèse, du transport et de la libération de la neurohormone(s) tandis que l'obscurité a fait diminuer la quantité libérée de neurohormone de la pars nervosa. 相似文献