Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat

This paper describes the induction of uterine eosinophilia as well as of deep endometrial edema and increase of uterine wet weight in the immature rat by the catecholestrogens 2-OH-estradiol and 4-OH-estradiol. These effects are thought to be mediated by eosinophils via a specific eosinophil receptor system. 4-OH-estradiol was equipotent with estradiol, whereas the effect of 2-OH-estradiol was significantly weaker.     

统计学:社会的物理学

玻尔 (Ｂｏｈｒ)、玻恩 (Ｂｏｒｎ )和薛定谔(Ｓｃｈｒ ｄｉｎｇｅｒ)于 2 0世纪 2 0年代把概率引入了量子世界的自然本性之中。这一引进搅乱了科学的哲学基础 ,使得一些学者感到非常困惑。然而早在 1 9世纪中期 ,当统计学的思想进入经典物理学的时候 ,关于偶然性、概率和决定论的争论就已经十分激烈了。詹姆斯·克拉克·麦克斯韦 (ＪａｍｅｓＣｌｅｒｋＭａｘｗｅｌｌ)把概率物理学 (ｐｒｏｂａｂｉｌｉｓｔｉｃｐｈｙｓｉｃｓ)带到了神秘主义的边缘 ,他说 :“正是物理科学的某个独特的函数带领我们来到了一个不可理解的事物的边缘 ,并嘱咐…     

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10?? and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.