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11.
12.
Zusammenfassung Es wird angenommen, dass mindestens zwei Fraktionen von intrazellulärem Kalzium am Kupplungsprozess zwischen Reizung und Kontraktion des Herzens beteiligt sind.
This work was supported by grants from the Manitoba Heart Foundation and the Medical Research Council of Canada. We thank Mr.Stan Vivian for development of the PDP8/I computer program to analyze the calcium uptake curves. 相似文献
This work was supported by grants from the Manitoba Heart Foundation and the Medical Research Council of Canada. We thank Mr.Stan Vivian for development of the PDP8/I computer program to analyze the calcium uptake curves. 相似文献
13.
Bailey Richard E. Bartos Dagmar Bartos F. Castro A. Dobson R. L. Grettie D. P. Kramer Rosanne Macfarlane Dorothy Sato K. 《Cellular and molecular life sciences : CMLS》1972,28(2):159-160
Résumé Un stress thermique aigu est un activateur rapide et puissant de la sécrétion du système rénineangiotensine et de l'aldosterone au cours d'une alimentation normo ou hyposodée, et peut être utilisé pour mesurer l'intégrité des systèmes de production de ces hormones. 相似文献
14.
The DNA sequence of human chromosome 22 总被引:75,自引:0,他引:75
Dunham I Shimizu N Roe BA Chissoe S Hunt AR Collins JE Bruskiewich R Beare DM Clamp M Smink LJ Ainscough R Almeida JP Babbage A Bagguley C Bailey J Barlow K Bates KN Beasley O Bird CP Blakey S Bridgeman AM Buck D Burgess J Burrill WD O'Brien KP 《Nature》1999,402(6761):489-495
Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome. 相似文献
15.
16.
M Debray-Sachs R Assan D Bailey J Hamburger 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,287(12):1161-1164
It is usually accepted that macrophages "activated" by lymphokines may be found cytotoxic against tumoral target cells but show no detectable cytotoxicity in in vitro tests using normal non tumoral cells as target cells. These data have been obtained mainly with the chromium-release test. The present paper describes a new test using normal isolated pancreatic cells as target cells and evaluating the effect of activated or non-activated macrophages on the insulin secretion response to glucose stimulation. The results show a striking decrease in this response following an 18-hr incubation of pancreatic islet cells with activated macrophages, as compared to that of the same cells incubated with control macrophages. This is clear evidence that activated macrophages may alter normal cells and suggests that their cytotoxic properties are not restricted to tumoral target cells. 相似文献
17.
Biological significance of the intermolecular crosslinks of collagen 总被引:26,自引:0,他引:26
18.
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region 总被引:1,自引:0,他引:1
Smyth DJ Cooper JD Bailey R Field S Burren O Smink LJ Guja C Ionescu-Tirgoviste C Widmer B Dunger DB Savage DA Walker NM Clayton DG Todd JA 《Nature genetics》2006,38(6):617-619
In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A --> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10). 相似文献
19.
Telomeres were first recognized as a bona fide constituent of the chromosome based on their inability to rejoin with broken chromosome ends produced by radiation. Today,
we recognize two essential and interrelated properties of telomeres. They circumvent the so-called end-replication problem
faced by genomes composed of linear chromosomes, which erode from their termini with each successive cell division. Equally
vital is the end-capping function that telomeres provide, which is necessary to deter chromosome ends from illicit recombination.
This latter property is critical in facilitating the distinction between the naturally occurring DNA double-strand breaks
(DSBs) found at chromosome ends (i.e., telomeres) and DSBs produced by exogenous agents. Here we discuss, in a brief historical narrative, key discoveries that
led investigators to appreciate the unique properties of telomeres in protecting chromosome ends, and the consequences of
telomere dysfunction, particularly as related to recombination involving radiation-induced DSBs.
Dedication. In appreciation of his heart-felt commitment to research and education, and the life-long influence he has had on the lives
of students and colleagues, the authors wish to dedicate this paper to Professor Joel S. Bedford.
Received 21 May 2007; received after revision 28 June 2007; accepted 6 August 2007 相似文献
20.
Todd JA Walker NM Cooper JD Smyth DJ Downes K Plagnol V Bailey R Nejentsev S Field SF Payne F Lowe CE Szeszko JS Hafler JP Zeitels L Yang JH Vella A Nutland S Stevens HE Schuilenburg H Coleman G Maisuria M Meadows W Smink LJ Healy B Burren OS Lam AA Ovington NR Allen J Adlem E Leung HT Wallace C Howson JM Guja C Ionescu-Tîrgovişte C;Genetics of Type Diabetes in Finland Simmonds MJ Heward JM Gough SC;Wellcome Trust Case Control Consortium Dunger DB Wicker LS Clayton DG 《Nature genetics》2007,39(7):857-864
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) 相似文献