A novel assistance data processing method for AGPS location system

A method for efficiently transmitting location assistance information to an MS （mobile station） over a control channel with minimal impact on the capacity of the control channel. A location server provides a difference between satellite positions that have been computed using Almanac data and Ephemeris data. Sending only the differ ence between the positions and satellite clock corrections computed using the two different data types. The total amount of information to be transmitted to a MS is significantly reduced. Furthermore, by providing rate of change information, the method allows the location assistance information to remain valid for a relatively long time after it has been received by the MS.     

A graph based sliding window multi join over data stream

Join operation is a critical problem when dealing with sliding window over data streams. There have been many optimization strategies for sliding window join in the literature, but a simple heuristic is always used for selecting the join sequence of many sliding windows, which is ineffectively. The graphbased approach is proposed to process the problem. The sliding window join model is introduced primarily. In this model vertex represent join operator and edge indicated the join relationship among sliding windows. Vertex weight and edge weight represent the cost of join and the reciprocity of join operators respectively. Then good query plan with minimal cost can be found in the model. Thus a complete join algorithm combining setting up model, finding optimal query plan and executing query plan is shown. Experiments show that the graphbased approach is feasible and can work better in above environment     

First record of genus Promalactis Meyrick (Lepidoptera: oecophoridae) from Cambodia with five new species

In this study, species of the genus Promalactis found in Cambodia are reviewed for the first time. Five new species, P. infundibulina sp. nov., P. prolixa sp. nov., P. seimana sp. nov., P. serratiola sp. nov., P. spiraliola sp. nov., are described. Promalactis albisquama Kim and Park is also newly discovered in Cambodia. Illustrations of adults and genitalia of each species are also provided with distributional data.

www.zoobank.org/urn:lsid:zoobank.org:pub:88AF790D-B677-498F-20A5B4-F287B5D52318     

A cloud based fuzzy approach for spatial site selection  in decision support system 

In decision support system for spatial site selection, the fuzzy synthetic evaluation is a useful way. However, the method can’t pay attention to the randomness in factors. To remedy the problem, this paper proposes a cloudedbase fuzzy approach which combines advantages of cloud transform and fuzzy synthetic evaluation. The cloud transform considers the randomness in the factors and product the higher concept layer for data mining. At the same time, the check mechanism controls the quality of partitions in factors. Then the fuzzy approach was used to get final evaluation value with randomness and fuzziness. It make the final result is optimization. Finally, performance evaluations show that this approach spent less runtime and got more accuracy than the fuzzy synthetic. The experiments prove that the proposed method is faster and more accuracy than the original method.     

Mechanisms of protein toxicity in neurodegenerative diseases

Protein toxicity can be defined as all the pathological changes that ensue from accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most neurodegenerative diseases manifest protein toxicity as one of their key pathogenic mechanisms, the details of which remain unclear. By systematically deconstructing the nature of toxic proteins, we aim to elucidate and illuminate some of the key mechanisms of protein toxicity from which therapeutic insights may be drawn. In this review, we focus specifically on protein toxicity from the point of view of various cellular compartments such as the nucleus and the mitochondria. We also discuss the cell-to-cell propagation of toxic disease proteins that complicates the mechanistic understanding of the disease progression as well as the spatiotemporal point at which to therapeutically intervene. Finally, we discuss selective neuronal vulnerability, which still remains largely enigmatic.     

A graph-based sliding window multi-join over data stream

Join operation is a critical problem when dealing with sliding window over data streams. There have been many optimization strategies for sliding window join in the literature, but a simple heuristic is always used for selecting the join sequence of many sliding windows, which is ineffectively. The graph-based approach is proposed to process the problem. The sliding window join model is introduced primarily. In this model vertex represent join operator and edge indicated the join relationship among sliding windows. Vertex weight and edge weight represent the cost of join and the reciprocity of join operators respectively. Then good query plan with minimal cost can be found in the model. Thus a complete join algorithm combining setting up model, finding optimal query plan and executing query plan is shown. Experiments show that the graph-based approach is feasible and can work better in above environment.     

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons

Actin plays a fundamental role in the regulation of spine morphology (both shrinkage and enlargement) upon synaptic activation. In particular, actin depolymerization is crucial for the spine shrinkage in NMDAR-mediated synaptic depression. Here, we define the role of SPIN90 phosphorylation/dephosphorylation in regulating actin depolymerization via modulation of cofilin activity. When neurons were treated with NMDA, SPIN90 was dephosphorylated by STEP61 (striatal-enriched protein tyrosine phosphatase) and translocated from the spines to the dendritic shafts. In addition, phosphorylated SPIN90 bound cofilin and then inhibited cofilin activity, suggesting that SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. We found that SPIN90 YE, a phosphomimetic mutant, remained in the spines after NMDAR activation where it bound cofilin, thereby effectively preventing actin depolymerization. This led to inhibition of the activity-dependent redistribution of cortactin and drebrin A, as well as of the morphological changes in the spines that underlie synaptic plasticity. These findings indicate that NMDA-induced SPIN90 dephosphorylation and translocation initiates cofilin-mediated actin dynamics and spine shrinkage within dendritic spines, thereby modulating synaptic activity.     

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 (PINK1), a novel AR-JP-linked gene. Here, we show that PINK1 mutants exhibit indirect flight muscle and dopaminergic neuronal degeneration accompanied by locomotive defects. Furthermore, transmission electron microscopy analysis and a rescue experiment with Drosophila Bcl-2 demonstrated that mitochondrial dysfunction accounts for the degenerative changes in all phenotypes of PINK1 mutants. Notably, we also found that PINK1 mutants share marked phenotypic similarities with parkin mutants. Transgenic expression of Parkin markedly ameliorated all PINK1 loss-of-function phenotypes, but not vice versa, suggesting that Parkin functions downstream of PINK1. Taken together, our genetic evidence clearly establishes that Parkin and PINK1 act in a common pathway in maintaining mitochondrial integrity and function in both muscles and dopaminergic neurons.     

Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster

Several transient receptor potential channels were recently found to be activated by temperature stimuli in vitro. Their physiological and behavioral roles are largely unknown. From a temperature-preference behavior screen of 27,000 Drosophila melanogaster P-insertion mutants, we isolated a gene, named pyrexia (pyx), encoding a new transient receptor potential channel. Pyx was opened by temperatures above 40 degrees C in Xenopus laevis oocytes and HEK293T cells. It was ubiquitously expressed along the dendrites of a subset of peripheral nervous system neurons and was more permeable to K(+) than to Na(+). Although some pyx alleles resulted in abnormal temperature preferences, pyx null flies did not have significantly different temperature preferences than wild-type flies. But 60% of pyx null flies were paralyzed within 3 min of exposure to 40 degrees C, whereas only 9% of wild-type flies were paralyzed by the same stimulus. From these findings, we propose that the primary in vivo role of Pyx is to protect flies from high-temperature stress.