Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.     

Facile synthesis of FeFe2O4 magnetic nanomaterial for removing methylene blue from aqueous solution

A facile and simple chemical precipitation method was utilized to synthesize FeFe_2O_4 magnetic nanomaterial for removing methylene blue(MB) from aqueous solution. Characterizations of this material were examined by using XRD, SEM, FT-IR, TGA-DTG and BET methods. Factors affecting the uptake of methylene blue, including p H, adsorption time, and MB initial concentration were also studied. The measured data were fitted by using four isotherm models including Langmuir, Freundlich, Sips and Temkin. Results showed that the Sips model offers the best fit to the data. In addition, the monolayer MB adsorption capacity obtained from the Langmuir model was 42.35 mg g~(-1) under the optimal conditions of p H = 10 and adsorption time = 80 min. In particular, the uptake of MB onto FeFe_2O_4 magnetic nanomaterial obtained from the kinetic and mechanism studies of the adsorption was in good agreement with prediction of the pseudo-first-order model, whereas the electrostatic interaction was found to play a primary mechanism.     

A new anti-hypoxia functional agent ―a Schizophyllum commune fermented broth and its possible biochemical mechanisms

In order to overcome hypoxia induced sickness,a stable source of anti-hypoxia functional agents, Schizophyllum commune fermented broth has been developed in this study. Animal experiments were conducted to examine its anti-hypoxia activities and possible mechanisms involved. The acute hypoxic experiment showed that Schizophyllum commune fermented broth could significantly prolong the survival time of mice. The underlying mechanisms were associated with improved energy metabolism based on a study carried out in rats exposed to a low pressure chamber simulating the low pressure environment of 8 000 m altitude. It was concluded that the Schizophyllum commune fermented broth was an effective anti-hypoxia functional agent and could be greatly bene- ficial to those living and working at high altitudes,such as people who reside in the reconstruction regions of Yushu.     

模拟隧道衬砌混凝土湿度演化规律

为了准确分析地下隧道衬砌混凝土内部湿度的演化特征,建立了用以计算江底隧道衬砌混凝土湿度时变规律的湿度模型,并对模拟隧道衬砌混凝土的试件进行了温湿度试验.数值计算与试验结果表明:所建立的考虑胶凝材料水化影响的湿度演化模型可以很好地对地下隧道衬砌混凝土的湿度分布特征进行预测和分析;在距离蒸发面较近的100 mm位置处,衬砌混凝土内部湿含量变化受扩散过程影响较大,在距离蒸发面较远的位置处湿含量时变主要是胶凝材料水化耗水所致;模型还预测了隧道衬砌服役10年时,距离蒸发面为100 mm以内的部分湿度均与环境湿度达到平衡;随着地下衬砌混凝土服役年限的延长,其内部湿度梯度逐渐向饱水面推进.     

New results on system of generalized quasi-Ky Fan inequalities with set-valued mappings in topological semilattice spaces

Under new assumptions, this paper obtains some extended versions of Ky Fan type inequality for a family of C-continuous set-valued mappings in the setting of topological semilattices. The obtained results are new and different from the corresponding known results in the literature. Some special cases of the main result are also discussed. Some examples are given to illustrate the results.     

某桥梁断桩事故的原因分析和处理对策

某桥梁桩基发生断桩事故,通过施工过程、现场取样等进行了致因分析,进而进行善后处理.提出了一些工程建议,为相似条件工程桩基施工提供技术参考.     

新疆农产品质量安全发展现状与对策

农产品质量安全直接关系到消费者的生存、生活和健康,越来越受到人们的普遍关注.主要分析了新疆农产品质量安全发展现状,并有针对性地提出了发展对策,要完善农产品质量安全监督管理法规体系、加快农业标准体系建设、依法开展农产品质量安全检验检测等.     

一种长距离浆体输送管道拒雷控制系统的设计

针对长距离矿浆管道输送存在的雷击灾害,提出了一种基于长距离浆体输送管道的拒雷控制系统,其系统包括浆体钢管、机电设备、综合有源+无源等离子拒雷装置和多个电涌保护器.在浆体钢管与机电设备之间的绝缘段的两侧分别安装第一电涌保护器和第二电涌保护器,采用瞬态接地的方式来实现等电位接地,克服了强制电流式阴极保护的矿浆钢管道不能直接接地的缺陷,同时防止了雷电侵入波对设备铁精矿管道的危害.实际应用表明了该方法的有效性.     

平流层通信系统在军事应用中的可行性探讨

平流层通信是利用长期运行于平流层高度的航空平台作为信息平台,提供大容量、远距离的信息服务。平流层通信系统具有费用低、部署快速、地面设备少、使用灵活、通信质量好等特点,其应用在军事中是一个新的突破。对平流层通信系统的特点及实现可行性进行了分析,提出了通信平台几个关键技术的解决方案,最后提出了平流层通信系统在军事中的应用。