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131.
Freud proposed that unwanted memories can be forgotten by pushing them into the unconscious, a process called repression. The existence of repression has remained controversial for more than a century, in part because of its strong coupling with trauma, and the ethical and practical difficulties of studying such processes in controlled experiments. However, behavioural and neurobiological research on memory and attention shows that people have executive control processes directed at minimizing perceptual distraction, overcoming interference during short and long-term memory tasks and stopping strong habitual responses to stimuli. Here we show that these mechanisms can be recruited to prevent unwanted declarative memories from entering awareness, and that this cognitive act has enduring consequences for the rejected memories. When people encounter cues that remind them of an unwanted memory and they consistently try to prevent awareness of it, the later recall of the rejected memory becomes more difficult. The forgetting increases with the number of times the memory is avoided, resists incentives for accurate recall and is caused by processes that suppress the memory itself. These results show that executive control processes not uniquely tied to trauma may provide a viable model for repression. 相似文献
132.
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis 总被引:23,自引:0,他引:23
Howe JR Bair JL Sayed MG Anderson ME Mitros FA Petersen GM Velculescu VE Traverso G Vogelstein B 《Nature genetics》2001,28(2):184-187
Juvenile polyposis (JP; OMIM 174900) is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. Previous studies have demonstrated a locus for JP mapping to 18q21.1 (ref. 3) and germline mutations in the homolog of the gene for mothers against decapentaplegic, Drosophila, (MADH4, also known as SMAD4) in several JP families. However, mutations in MADH4 are only present in a subset of JP cases, and although mutations in the gene for phosphatase and tensin homolog (PTEN) have been described in a few families, undefined genetic heterogeneity remains. Using a genome-wide screen in four JP kindreds without germline mutations in MADH4 or PTEN, we identified linkage with markers from chromosome 10q22-23 (maximum lod score of 4.74, straight theta=0.00). We found no recombinants using markers developed from the vicinity of the gene for bone morphogenetic protein receptor 1A (BMPR1A), a serine-threonine kinase type I receptor involved in bone morphogenetic protein (BMP) signaling. Genomic sequencing of BMPR1A in each of these JP kindreds disclosed germline nonsense mutations in all affected kindred members but not in normal control individuals. These findings indicate involvement of an additional gene in the transforming growth factor-beta (TGF-beta) superfamily in the genesis of JP, and document an unanticipated function for BMP in colonic epithelial growth control. 相似文献
133.
Dominant effector genetics in mammalian cells 总被引:6,自引:0,他引:6
Xu X Leo C Jang Y Chan E Padilla D Huang BC Lin T Gururaja T Hitoshi Y Lorens JB Anderson DC Sikic B Luo Y Payan DG Nolan GP 《Nature genetics》2001,27(1):23-29
We have expressed libraries of peptides in mammalian cells to select for trans-dominant effects on intracellular signaling systems. As an example-and to reveal pharmacologically relevant points in pathways that lead to Taxol resistance-we selected for peptide motifs that confer resistance to Taxol-induced cell death. Of several peptides selected, one, termed RGP8.5, was linked to upregulation of expression of the gene ABCB1 (also known as MDR1, for multiple drug resistance) in HeLa cells. Our data indicate that trans-dominant effector peptides can point to potential mechanisms by which signaling systems operate. Such tools may be useful in functional genomic analysis of signaling pathways in mammalian disease processes. 相似文献
134.
Owens Valley, California, was markedly different during the Wisconsin glacial stage from what it is today. Alpine glaciers bounded the Sierra Nevada, and pluvial Owens Lake reached highstands and overflowed its natural basin. We analyzed three layers from two packrat middens, dated to ca 23,000-14,500 yr BP, obtained from Haystack Mountain (1155 m) only 10 m above and Juniperus osteosperma ) and single-needle pinyon pine ( Pinus monophylla ) woodland existed at the site. In the layers dated to ca 17,500 and 16,000 yr BP, macrofossils document the presence of Rocky Mountain juniper ( Juniperus scopulorum ), a species that no longer occurs in California. It is suggested that meltwater from the retreating glacial ice inundated the Owens River Lake chain causing pluvial Owens Lake to reach its highstand. This caused an increase in effective moisture, due to high groundwater, allowing the mesophytic Rocky Mountain juniper to exist at the site. 相似文献
135.
136.
Habitat use and food selection data were collected for deer mice ( Peromyscus maniculatus ), montane voles ( Microtus montanus ), Ord's kangaroo rats ( Dipodomys ordii ), and Townsend's ground squirrels ( Spermophilus townsendii ) near a sagebrush ( Artemisia tridentata )/crested wheatgrass ( Agropyron cristatum ) interface in southeastem Idaho. Significantly more captures occurred in the native sagebrush habitat than in areas planted in crested wheatgrass or in disturbed sites. Crested wheatgrass, a prolific seed producer, still accounted for over 30% of the total captures. Montane voles and Townsend's ground squirrels (during periods of aboveground activity) used the crested wheatgrass habitat throughout the summer, while deer mice and, Ord's kangaroo rats exhibited heavy use after seed set. 相似文献
137.
Loran C. Anderson 《西北部美国博物学家》2011,43(2)
Two groups of glabrous, narrow-leaved Chrysothamnus viscidiflorus (Asteraceae) are perceived, and appropriate taxonomic combinations are made, i.e., C. v. ssp. viscidiflorus var. stenophyllus and C. v. ssp. axillaris. The two are fairly distinct geographically, and they can be separated by floral morphology. A key to all species of section Chrysothamnus (to which C. viscidiflorus belongs) is given. 相似文献
138.
Tamara K. Anderson 《西北部美国博物学家》2011,65(2)
Eighty-two soil samples and additional hand-collection in Wind Cave National Park yielded over 2000 terrestrial gastropod specimens. The specimens represent 26 different species, including a South Dakota species of concern, Vertigo arthuri . New South Dakota state records for Gastrocopta pellucida and Vertigo tridentata were recorded. Samples from grassland habitats were less likely to contain snails and had lower species richness than samples from either forest or shrubland habitats. Canyons, creek beds, bases of limestone cliffs, and shrublands are important habitats for snails in the park. 相似文献
139.
Electrical stimulation of certain hypothalamic regions in cats and rodents can elicit attack behaviour, but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their relationship to mating circuits have not been clear. Genetic methods for neural circuit manipulation in mice provide a potentially powerful approach to this problem, but brain-stimulation-evoked aggression has never been demonstrated in this species. Here we show that optogenetic, but not electrical, stimulation of neurons in the ventromedial hypothalamus, ventrolateral subdivision (VMHvl) causes male mice to attack both females and inanimate objects, as well as males. Pharmacogenetic silencing of VMHvl reversibly inhibits inter-male aggression. Immediate early gene analysis and single unit recordings from VMHvl during social interactions reveal overlapping but distinct neuronal subpopulations involved in fighting and mating. Neurons activated during attack are inhibited during mating, suggesting a potential neural substrate for competition between these opponent social behaviours. 相似文献
140.
Madhusudhan N Harrington J Stevenson KB Nymeyer S Campo CJ Wheatley PJ Deming D Blecic J Hardy RA Lust NB Anderson DR Collier-Cameron A Britt CB Bowman WC Hebb L Hellier C Maxted PF Pollacco D West RG 《Nature》2011,469(7328):64-67
The carbon-to-oxygen ratio (C/O) in a planet provides critical information about its primordial origins and subsequent evolution. A primordial C/O greater than 0.8 causes a carbide-dominated interior, as opposed to the silicate-dominated composition found on Earth; the atmosphere can also differ from those in the Solar System. The solar C/O is 0.54 (ref. 3). Here we report an analysis of dayside multi-wavelength photometry of the transiting hot-Jupiter WASP-12b (ref. 6) that reveals C/O?≥?1 in its atmosphere. The atmosphere is abundant in CO. It is depleted in water vapour and enhanced in methane, each by more than two orders of magnitude compared to a solar-abundance chemical-equilibrium model at the expected temperatures. We also find that the extremely irradiated atmosphere (T?>?2,500?K) of WASP-12b lacks a prominent thermal inversion (or stratosphere) and has very efficient day-night energy circulation. The absence of a strong thermal inversion is in stark contrast to theoretical predictions for the most highly irradiated hot-Jupiter atmospheres. 相似文献