Serum and liver radioactivity levels in mice after intraperitoneal and subcutaneous injection of [14C]orotic acid

Summary [¹⁴C]Orotic acid was rapidly distributed in blood after, both i.p. and s.c. injection but was not completely absorbed from the peritoneal cavity until 20 min after injection. S.c. injection should be an acceptable alternative to i.p. injection although the incorporation into the liver acid soluble- and RNA-fractions was somewhat delayed after the s.c. injection.This work was supported by grants from the Carl Trygger Foundation and the Foundation of Director Albert Påhlsson.     

The effect of methaqualone on prenatal development in the rat

Methaqualone treatment of pregnant rats in doses of 100-200 mg/kg day produces resorption and a series of anomalies whose incidence increases with the dose-level employed.     

Destruction of the platelet aggregating activity of ristocetin A

Summary Hydrolysis of ristocetin A in 0.1 N HCl at 37°C for 2 h resulted in the loss of its ability to induce platelet aggregation in platelet-rich plasma derived from guinea-pigs and humans. However its antibiotic activity againstStaph. aureus was not lost.This work was supported, in part, by a contract from the National Heart, Lung, and Blood Institute (USPHS).     

Properties of vascular permeability factor in human sera for guinea-pig skin.

Properties of vascular permeability factor in native human sera (PF/Nat) showed close similarities with those of necrotizing factor. Time course studies revealed that skin necrosis could be initiated by enhanced vascular permeability.