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211.
Szeltner Z Alshafee I Juhász T Parvari R Polgár L 《Cellular and molecular life sciences : CMLS》2005,62(19-20):2376-2381
The PREPL (previously called KIAA0436) gene encodes a putative serine peptidase from the prolyl oligopeptidase family. A chromosomal deletion involving the PREPL gene leads to a severe syndrome with multiple symptoms. Homology with oligopeptidase B suggested that the enzyme cleaves after an arginine or lysine residue. Several PREPL splice variants have been identified, and a 638-residue variant (PREPL A) was expressed in Escherichia coli and purified. Its secondary structure was similar to that of oligopeptidase B, but differential-scanning calorimetry indicated a higher conformational stability. Dimerization may account for the enhanced stability. Unexpectedly, the PREPL A protein did not cleave peptide substrates containing a P1 basic residue, but did slowly hydrolyse an activated ester substrate, and reacted with diisopropyl fluorophosphate. These results indicated that the catalytic serine is a reactive residue. However, the negligible hydrolytic activity suggests that the function of PREPL A is different from that of the other members of the prolyl oligopeptidase family. 相似文献
212.
Mannella N Yang WL Zhou XJ Zheng H Mitchell JF Zaanen J Devereaux TP Nagaosa N Hussain Z Shen ZX 《Nature》2005,438(7067):474-478
A characteristic feature of the copper oxide high-temperature superconductors is the dichotomy between the electronic excitations along the nodal (diagonal) and antinodal (parallel to the Cu-O bonds) directions in momentum space, generally assumed to be linked to the 'd-wave' symmetry of the superconducting state. Angle-resolved photoemission measurements in the superconducting state have revealed a quasiparticle spectrum with a d-wave gap structure that exhibits a maximum along the antinodal direction and vanishes along the nodal direction. Subsequent measurements have shown that, at low doping levels, this gap structure persists even in the high-temperature metallic state, although the nodal points of the superconducting state spread out in finite 'Fermi arcs'. This is the so-called pseudogap phase, and it has been assumed that it is closely linked to the superconducting state, either by assigning it to fluctuating superconductivity or by invoking orders which are natural competitors of d-wave superconductors. Here we report experimental evidence that a very similar pseudogap state with a nodal-antinodal dichotomous character exists in a system that is markedly different from a superconductor: the ferromagnetic metallic groundstate of the colossal magnetoresistive bilayer manganite La1.2Sr1.8Mn2O7. Our findings therefore cast doubt on the assumption that the pseudogap state in the copper oxides and the nodal-antinodal dichotomy are hallmarks of the superconductivity state. 相似文献
213.
CD36 is a sensor of diacylglycerides 总被引:1,自引:0,他引:1
Hoebe K Georgel P Rutschmann S Du X Mudd S Crozat K Sovath S Shamel L Hartung T Zähringer U Beutler B 《Nature》2005,433(7025):523-527
Toll-like receptor 2 (TLR2) is required for the recognition of numerous molecular components of bacteria, fungi and protozoa. The breadth of the ligand repertoire seems unusual, even if one considers that TLR2 may form heteromers with TLRs 1 and 6 (ref. 12), and it is likely that additional proteins serve as adapters for TLR2 activation. Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36 (oblivious) causes a recessive immunodeficiency phenotype in which macrophages are insensitive to the R-enantiomer of MALP-2 (a diacylated bacterial lipopeptide) and to lipoteichoic acid. Homozygous mice are hypersusceptible to Staphylococcus aureus infection. Cd36(obl) macrophages readily detect S-MALP-2, PAM(2)CSK(4), PAM(3)CSK(4) and zymosan, revealing that some--but not all--TLR2 ligands are dependent on CD36. Already known as a receptor for endogenous molecules, CD36 is also a selective and nonredundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer. 相似文献
214.
215.
Z. Šormová K. Šebesta J. Bauerová O. Melichar F. Šorm 《Cellular and molecular life sciences : CMLS》1960,16(5):189-190
Zusammenfassung Es wurde eine entwicklungsfördernde Wirkung von 5-Bromuracil und 5-Nitrouracil bereits in geringen Mengen auf manche Pflanzen (unter anderem Tomaten, Gurken und Gartenlattich) festgestellt. 5-Bromuracil wird dabei nicht in die Pflanzennukleinsäuren eingebaut, sondern unterliegt einem schnellen Abbau; weiterhin verursacht der Stoff eine Hemmung des Uracilabbaues. Die Möglichkeit einer Beeinflussung der genetischen Eigenschaften wird diskutiert. 相似文献
216.
Summary The addition of simple quaternary salts (as I and II) to solutions of local anaesthetics, effects a pronounced prolongation of the time of complete infiltration anaesthesia. These salts have no effect on the time of surface anaesthesia. Other pharmacological characteristics of these mixtures were also determined. 相似文献
217.
Zusammenfassung Bei Mäusen wurde die Strahlenschutzwirksamkeit des 5-Ethoxytryptamins und 5-Methoxytryptamins mit derjenigen von 5-Hydroxytriptamin, SAS (Benzothiophenverbindung) und 5-Methoxy-SAS verglichen. Die Ergebnisse zeigen, dass die Schutzwirksamkeit des 5-Ethoxytryptamins der des SAS sehr ähnlich ist. 相似文献
218.
Zusammenfassung Für das Aconitum-Alkaloid Napellin wurden auf Grund einer eingehenden Diskussion des Tatsachenmaterials die Strukturen XI bzw. X vorgeschlagen. Das Alkaloid Songorin ist das dazugehörige Ring-D-Keton. 相似文献
219.
220.
In man, in the process of evolution the proprioceptive reflexes from the chest muscle during apnea become weak. Probably the impulses from the respiratory stretch receptors do not take part in self-regulation of eupnea. 相似文献