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231.
232.
233.
T. Matsuoka T. Nishizaki Y. Ikeuchi Y. Okada K. Sumino 《Cellular and molecular life sciences : CMLS》1997,53(3):233-236
Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety
of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons),
and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency
of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward
currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the
cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances
of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower
slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT2 receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope
conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the
outward and fast inward currents may be mediated respectively by the 5-HT2 receptor, which is coupled to a G-protein, and by the 5-HT3 receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT2 and 5-HT3 receptors.
Received 27 September 1996; received after revision 4 November 1996; accepted 7 November 1996 相似文献
234.
系统研究了正常及反常赖政-悌曼反应(NormalorAbnormalReliner-TiemannReavction,NRYorART);研究了相转移住化方法和超声波辐射技术及其在正常Reliner—Tiemann(NRT)反应中的应用,从而使反应条件温和,效率增加,对邻比大,时间缩短,取得较好收效。 相似文献
235.
The non-steroidal ecdysone agonist RH-5849 (1,2-dibenzoyl-l-tert-butylhydrazine) was found to be an effective neurotoxicant on injection into the American bird grasshopper,Schistocerca americana (Drury). Treated grasshoppers became immediately hyperactive, followed by loss of coordination, paralysis and eventually death. We also discovered that this compound induced bilateral autotomy of the metathoracic legs during the early stages of intoxication. However, no evidence of ecdysonergic or morphogenetic activities was observed. Synergism studies with neurotoxins of known mode of action suggested that RH-5849 has a mechanism of action similar to that of 4-amino pyridine, which blocks potassium channels. 相似文献
236.
Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system
H. Baker B. DeAngelis O. Frank M. Khalil S. H. Hutner E. R. Baker 《Cellular and molecular life sciences : CMLS》1996,52(6):597-599
Using a prokaryote (Escherichia coli) and a metazoa-resembling eukaryote (Ochromonas danica), we surveyed antioxidants which might overcome redox stress imposed by menadione sodium bisulphite (MD) and buthionine sulphoximine (BSO). BSO oxidant stress was evident only inO. danica; MD oxidant stress was evident in both organisms. Glutathione, its precursors, e.g. cysteine, homocysteine, and 2-oxo-4-thiazolidine carboxylic acid, and red blood cells, emerged as prime antioxidants for relieving BSO and MD oxidant stress. BSO and MD oxidant activity and antioxidant-annulling effect inO. danica were judged comparable to those found in animal cells whereas the resultsE. coli were not entirely equivalent. TheO. danica system emerged as a practical, rapid, and useful system for pinpointing oxidant stressors and antioxidants, and shows promise for studies with mammalian systems. 相似文献
237.
E. S. Fiala R. S. Sodum M. Bhattacharya H. Li 《Cellular and molecular life sciences : CMLS》1996,52(9):922-926
Reaction with peroxynitrite at pH 7.4 and 37°C was found to increase the 8-oxodeoxyguanosine levels in calf thymus DNA 35-38-fold. This oxidation of deoxyguanosine, as well as the peroxynitrite-mediated nitration of tyrosine to 3-nitrotyrosine, was significantly inhibited by ascorbic acid, glutathione and (–)-epigallocatechin gallate, a polyphenolic antioxidant present in tea. For 50% inhibition of the oxidation of deoxyguanosine to 8-oxodeoxyguanosine, 1.1, 7.6 of 0.25 mM ascorbate, glutathione or (–)-epigallocatechin gallate, respectively, was required. For 50% inhibition of tyrosine nitration, the respective concentrations were 1.4, 4.6 or 0.11 mM. Thus, (–)-epigallocatechin gallate is a significantly better inhibitor of both reactions than either ascorbate or glutathione. Reaction of (–)-epigallocatechin gallate with peroxynitrite alone resulted in the formation of a number of products. Ultraviolet spectra of two of these suggest that the tea polyphenol and/or its oxidation products are nitrated by peroxynitrite. 相似文献
238.
介绍2-丁烯醛与苯硫酚之间的酸催化分子间一步成环反应,合成一种二氢苯并噻喃衍生物的新方法,产品收率高达84%。 相似文献
239.
用子波变换分析方法实时监测视觉诱发电位的潜伏期 总被引:1,自引:0,他引:1
诱发电位的实时监测在临床中有重要意义。本文提出利用多分辨率子波分析技术来实时监测视觉诱发电位的潜伏期。为克服随机噪声的影响,我们引入相邻响应的相关系数来修正所检测得的潜伏期的偏移,并应用前一次响应的波峰位置来决定当前的搜寻范围。实验表明,本方法能实时监测视觉诱发电位的潜伏期。 相似文献
240.
Global warming: Take action or wait? 总被引:1,自引:0,他引:1
W.S.Broecder 《科学通报(英文版)》2006,51(9):1018-1029
Of all the changes wrought by human activity, the buildup in our atmosphere of the greenhouse gases, carbon dioxide, methane and nitrous oxide, has gener- ated the most contentious debate. Environmentalists warn that in the absence of firm action, over th… 相似文献