Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.

Neurofibromatosis type I (NF1) is one of the most common single-gene disorders that causes learning deficits in humans. Mice carrying a heterozygous null mutation of the Nfl gene (Nfl(+/-) show important features of the learning deficits associated with NF1 (ref. 2). Although neurofibromin has several known properties and functions, including Ras GTPase-activating protein activity, adenylyl cyclase modulation and microtubule binding, it is unclear which of these are essential for learning in mice and humans. Here we show that the learning deficits of Nf1(+/-) mice can be rescued by genetic and pharmacological manipulations that decrease Ras function. We also show that the Nf1(+/-) mice have increased GABA (gamma-amino butyric acid)-mediated inhibition and specific deficits in long-term potentiation, both of which can be reversed by decreasing Ras function. Our results indicate that the learning deficits associated with NF1 may be caused by excessive Ras activity, which leads to impairments in long-term potentiation caused by increased GABA-mediated inhibition. Our findings have implications for the development of treatments for learning deficits associated with NF1.     

新型全固态铁离子敏感电极研究

采用稀土电极材料六硼化镧制备了一种新的全固态铁离子敏感电极。研究了该敏感电极在常见介质中对Ｆｅ３＋的响应行为。结果表明，该铁离子敏感电极在１．５ｍｏｌ／ＬＨ３ＰＯ４介质中的线性响应范围、检测下限和响应斜率分别为１．０×１０－５～１．０×１０－１ｍｏｌ／ＬＦｅ３＋，６．０×１０－６ｍｏｌ／ＬＦｅ３＋和６０ｍＶ／ｐＣ，且具有较好的选择性。     

The General Machining Process Simulator GMPS

Ｔｈｅ　Ｇｅｎｅｒａｌ　Ｍａｃｈｉｎｉｎｇ　Ｐｒｏｃｅｓｓ　Ｓｉｍｕｌａｔｏｒ　ＧＭＰＳＸｉａｏＴｉａｎｙｕａｎ，ＹａｎｇＧａｎｇ＆ＬｉＸｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＡｕｔｏｍａｔｉｏｎ，ＴｓｉｎｇｈｕａＵｎｉｖｅｒｓｉｔｙ，Ｂｅｉｊｉｎｇ，Ｃｈｉ...     

三峡二期围堰工程几个问题的研究及实践

三峡工程二期围堰是三峡工程最重要的临时建筑物之一，大江截流水深大，流量大；防渗墙深度大，工程量大，工期紧，且还要穿过各种复杂地层，通过试验，研究，采取有效地对策确保大江安全，顺利截流，基坑按三峡总工期目标要求抽干，检查渗漏量仅为设计估计量的1／10。     

轻质页岩脱色性能的研究

本文研究了轻质页岩的脱色性能，其最佳活化温度为６００～７００℃。最佳活化时间为０．５ｈ，并获得了有意义的结论。     

关于毛泽东的反对错误倾向的分析与思考

毛泽东关于反对错误倾向的思想是非常深刻、非常系统的。完全可以说,毛泽东关于反对错误倾向的思想是一整套严密的理论。我们应该学习和继承这一理论。但在反对错误倾向的问题上,毛泽东有沉重的经验教训值得我们记取。     

中厚板矫直技术发展的现状与展望

介绍了国内外矫直技术与矫直设备的发展水平与方向 ,在简要介绍中厚板矫直机理的基础上 ,指出了目前我国中厚板矫直技术存在的一些差距与不足 ,为我国中厚板矫直设备的改造提供了一定的参考依据。     

Studies on the Dd antigen-antibody system. I. The nature of antigen Dd and its antibodies

Summary The nature of antigen Dd, an antigen present in the extracts of human dandruff which precipitates human sera selectively, and antibodies reacting with it are reported.This work was supported through U.G.C. Grant No. F.23-230/75/SR II. H.K. participated in this study, first as J.R.F. of U.G.C. and then as S.R.F. of I.C.M.R. We are grateful to Dr Baruch S. Blumberg for his invaluable suggestions and to Professor H. Walter for the gift of IgG, IgM and IgA immune sera.     

从阿根廷金融危机分析"钉住汇率制"的利弊

1 32 0亿美元的巨额外债是阿根廷金融危机的导火索 ,而阿根廷在汇率制度上的僵化是产生金融危机的重要原因。本文以阿根廷金融危机为背景 ,分析钉住汇率制的优点主要是有利于国际贸易与资本流动 ;缺点主要是丧失独立的货币政策且不能利用汇率调整应对复杂多变的世界经济形势。对我国的启迪是人民币汇率的稳定不等于没有波动 ,汇率形成机制要市场化。     

生物酶在羊毛织物防毡缩工艺中的应用

将蛋白酶和转移酶E2进行复配，应用于羊毛织物防缩整理，探索了最佳复配方案和工艺条件，经复合酶处理过的羊毛织物，其毡缩率可降低到1.26%，小于机可洗要求3％，应用扫描电镜观察了织物鳞片表层的破坏情况，进而了解酶作用的结果。