基于DMC204的数控系统开发与应用

提出了在Windows操作系统平台上实现实时多任务处理的CNC系统控制体系结构，并依据这一结构方案，具体实现了一个具有开放性、模块化特征的简易CNC应用软件，该数控软件在经改造后的CK6140H普通车床上应用结果表明，车床的运行精度和效率大为提高。     

大地测量学数学基础Torben Krarup论文选集

大地测量学数学原理是现代各种地面测量和卫星定位导航的基础。作为20世纪最著名的大地测量学家之—Torben Krarup在该领域做出了杰出的贡献。他是开创现代大地测量学的先锋，从1969年就在该领域被广泛认同，1999年被国际大地测量协会授予最高奖—Levallois奖。     

中国明代弹道学史料的考辨与述评

对明代火器文献进行分析,认为学术界关于“中国古代弹道知识是由西方传来”之说值得商榷．中国弹道学知识的形成有其自身的特点,初步形成了能在一定程度上反映火器命中技术发展规律的弹道理论,在中国火器弹道科学思想史上占有重要地位．     

具有时滞和常数收获率种群模型的稳定性

在生态系统中,种群的稳定性一直是研究的重点内容之一,在已有结果的基础上,考虑了一个同时具有时滞和常数收获率的捕食-被捕食模型,通过对特征方程的研究,给出了正平衡点稳定的充分条件.利用Matlab软件给出了种群模型的数值模拟结果,描述出了相平面的相轨线和种群数量随时间变化的曲线,进而更加直观地预测种群的发展趋势.     

基于OBB层次结构碰撞检测的改进算法

方向包围盒（Oriented bounding box：OBB）的构造以及包围盒的相交测试的计算量都比较大,严重影响了在模拟、仿真的应用,尤其是有变形物体的场景。引入近似凸包的思想提出一种快速构造方向包围盒算法,很大程度上减少了构造方向包围盒（0BB）层次结构的顶点数,改进后的算法在降低构造层次结构时间的同时,对方向包围盒的紧密性代价几乎没有影响,在有些时候还提高了包围盒的紧密性。在包围盒相交测试方面,提留了一种基于筒单羽以爱的相交须刿方击,该算法在检测过程中省去了大量包围盒的相交测试计算,提高了相交测试的速度。最后将两种改进算法联合的碰撞检测框架与常用的基于均值和协方差矩阵的包围盒构造和基于分裂轴的算法进行比较,证明了算法具有高效性。     

茉莉酸受体多功能纳米探针的合成与应用

将巯基丙酸修饰的CdTe量子点和植物激素茉莉酸通过一步法偶联到表面修饰氨基的Fe3O4纳米颗粒表面,合成了一种同时具有荧光信号、磁响应性能和特异性标记植物原生质体中茉莉酸受体的多功能磁性荧光纳米探针. 荧光光谱测试表明该探针保持了CdTe量子点荧光性能,具有荧光强度高,适用体系的pH范围宽,抗光漂白性能好等优点. 磁响应及磁滞回线测试充分说明该探针具有良好的超顺磁性. 使用该探针对绿豆原生质体中茉莉酸受体进行成像,结果表明,该探针对茉莉酸受体具有选择性标记的功能,茉莉酸受体主要存在于原生质体膜上. 该标记方法简单方便,能为茉莉酸信号转导研究提供可视化的信息.     

Catalysis of protein folding by prolyl isomerase

Rates of protein folding reactions vary considerably. Some denatured proteins regain the native conformation within milliseconds or seconds, whereas others refold very slowly in the time range of minutes or hours. Varying folding rates are observed not only for different proteins, but can also be detected for single polypeptide species. This originates from the co-existence of fast- and slow-folding forms of the unfolded protein, which regain the native state with different rates. The proline hypothesis provides a plausible explanation for this heterogeneity. It assumes that the slow-folding molecules possess non-native isomers of peptide bonds between proline and another residue, and that crucial steps in the refolding of the slow-folding molecules are limited in rate by the slow reisomerization of such incorrect proline peptide bonds. Recently the enzyme peptidyl-prolyl cis-trans isomerase (PPIase) was discovered and purified from pig kidney. It catalyses efficiently the cis in equilibrium trans isomerization of proline imidic peptide bonds in oligopeptides. Here we show that it also catalyses slow steps in the refolding of a number of proteins of which fast- and slow-folding species have been observed and where it was suggested that proline isomerization was involved in slow refolding. The efficiency of catalysis depends on the accessibility for the isomerase of the particular proline peptide bonds in the refolding protein chain.     

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome). HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans and apes. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CD8 surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients.     

Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin,and their mixture

We compared the effects ofAlzheimer's peptide (Abeta1-42), a,-antichymotrypsin (ACT) and an ACT/Abeta1-42 mixture on human glioma DK-MG cells. The solution of Abeta (5 microM) formed by 2-h incubation at room temperature induced tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 levels by 55 and 45%, respectively, and increased gelatinase B activity by 67%, while exposure of cells to the ACT/Abeta1-42 mixture (1:10 molar ratio ACT: Abeta1-42) under the same experimental conditions showed no effect on IL-6 levels or gelatinase B activity, but strongly induced TNF-alpha (by 190%), compared to the controls. Stimulation of the cells with Abeta1-42 alone, but not with ACT, increased by about 20% low-density lipoprotein (LDL) uptake and mRNA levels for LDL receptor and HMG-CoA reductase, while the ACT/Abeta1-42 mixture significantly increased LDL uptake (by 50%), up-regulated mRNA levels for LDL receptor and HMG-CoA reductase by 48 and 63%, respectively, and increased lipid accumulation by about 20-fold. These data suggest a possible new role for Abeta in Alzheimer's disease through its interaction with the inflammatory reactant, ACT.