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101.
R. B. Chronister J. J. Bernstein S. F. Zornetzer L. E. White Jr. 《Cellular and molecular life sciences : CMLS》1973,29(5):588-589
Zusammenfassung Erstmaliger morphometrischer Nachweis bei 2 Gruppen reifer, altersunterschiedlicher Ratten, dass die Zahl der Synapsen im Hippocampus mit dem Alter zunimmt, wobei die effektive Steigerungsrate auch mit Umwelteinflüssen zusammenhängen könnte.
This work was supported by grants from the U.S. National Institutes of Health to JJB (No. NS-06164) and to LEW,Jr., (No. NS-09358) and funds from the Center for Neurobiological Sciences of the University of Florida (No. NIH-MH-10320). 相似文献
This work was supported by grants from the U.S. National Institutes of Health to JJB (No. NS-06164) and to LEW,Jr., (No. NS-09358) and funds from the Center for Neurobiological Sciences of the University of Florida (No. NIH-MH-10320). 相似文献
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Two distinct polypeptides have been isolated from rat heart and ox blood. They are both found to be effective in forming complexes with sodium ions, and it is suggested that they may have a function in stabilizing sodium ion activity. 相似文献
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Carlton JM Adams JH Silva JC Bidwell SL Lorenzi H Caler E Crabtree J Angiuoli SV Merino EF Amedeo P Cheng Q Coulson RM Crabb BS Del Portillo HA Essien K Feldblyum TV Fernandez-Becerra C Gilson PR Gueye AH Guo X Kang'a S Kooij TW Korsinczky M Meyer EV Nene V Paulsen I White O Ralph SA Ren Q Sargeant TJ Salzberg SL Stoeckert CJ Sullivan SA Yamamoto MM Hoffman SL Wortman JR Gardner MJ Galinski MR Barnwell JW Fraser-Liggett CM 《Nature》2008,455(7214):757-763
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species. 相似文献
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Pain A Böhme U Berry AE Mungall K Finn RD Jackson AP Mourier T Mistry J Pasini EM Aslett MA Balasubrammaniam S Borgwardt K Brooks K Carret C Carver TJ Cherevach I Chillingworth T Clark TG Galinski MR Hall N Harper D Harris D Hauser H Ivens A Janssen CS Keane T Larke N Lapp S Marti M Moule S Meyer IM Ormond D Peters N Sanders M Sanders S Sargeant TJ Simmonds M Smith F Squares R Thurston S Tivey AR Walker D White B Zuiderwijk E Churcher C Quail MA Cowman AF Turner CM Rajandream MA Kocken CH 《Nature》2008,455(7214):799-803
Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry. 相似文献
108.
Whitehurst AW Bodemann BO Cardenas J Ferguson D Girard L Peyton M Minna JD Michnoff C Hao W Roth MG Xie XJ White MA 《Nature》2007,446(7137):815-819
Abundant evidence suggests that a unifying principle governing the molecular pathology of cancer is the co-dependent aberrant regulation of core machinery driving proliferation and suppressing apoptosis. Anomalous proteins engaged in support of this tumorigenic regulatory environment most probably represent optimal intervention targets in a heterogeneous population of cancer cells. The advent of RNA-mediated interference (RNAi)-based functional genomics provides the opportunity to derive unbiased comprehensive collections of validated gene targets supporting critical biological systems outside the framework of preconceived notions of mechanistic relationships. We have combined a high-throughput cell-based one-well/one-gene screening platform with a genome-wide synthetic library of chemically synthesized small interfering RNAs for systematic interrogation of the molecular underpinnings of cancer cell chemoresponsiveness. NCI-H1155, a human non-small-cell lung cancer line, was employed in a paclitaxel-dependent synthetic lethal screen designed to identify gene targets that specifically reduce cell viability in the presence of otherwise sublethal concentrations of paclitaxel. Using a stringent objective statistical algorithm to reduce false discovery rates below 5%, we isolated a panel of 87 genes that represent major focal points of the autonomous response of cancer cells to the abrogation of microtubule dynamics. Here we show that several of these targets sensitize lung cancer cells to paclitaxel concentrations 1,000-fold lower than otherwise required for a significant response, and we identify mechanistic relationships between cancer-associated aberrant gene expression programmes and the basic cellular machinery required for robust mitotic progression. 相似文献
109.
Jones FC Grabherr MG Chan YF Russell P Mauceli E Johnson J Swofford R Pirun M Zody MC White S Birney E Searle S Schmutz J Grimwood J Dickson MC Myers RM Miller CT Summers BR Knecht AK Brady SD Zhang H Pollen AA Howes T Amemiya C;Broad Institute Genome Sequencing Platform & Whole Genome Assembly Team Baldwin J Bloom T Jaffe DB Nicol R Wilkinson J Lander ES Di Palma F Lindblad-Toh K Kingsley DM 《Nature》2012,484(7392):55-61
Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results indicate that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive evolution in nature. 相似文献
110.