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61.
Malanchi I Peinado H Kassen D Hussenet T Metzger D Chambon P Huber M Hohl D Cano A Birchmeier W Huelsken J 《Nature》2008,452(7187):650-653
Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sustaining stemness have not been identified. In murine skin, follicular morphogenesis is driven by bulge stem cells that specifically express CD34. Here we identify a population of cells in early epidermal tumours characterized by phenotypic and functional similarities to normal bulge skin stem cells. This population contains CSCs, which are the only cells with tumour initiation properties. Transplants derived from these CSCs preserve the hierarchical organization of the primary tumour. We describe beta-catenin signalling as being essential in sustaining the CSC phenotype. Ablation of the beta-catenin gene results in the loss of CSCs and complete tumour regression. In addition, we provide evidence for the involvement of increased beta-catenin signalling in malignant human squamous cell carcinomas. Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas. 相似文献
62.
澳大利亚及斯洛文尼亚稻绿蝽(Nezara viridula)外生殖器微细结构电镜观察 总被引:2,自引:0,他引:2
齐宝瑛 《内蒙古师范大学学报(自然科学版)》2000,29(1)
澳大利亚和斯洛文尼亚的稻绿蝽因不完全的生殖隔离而曾被认为是两个不同的但互为姊妹的种群 .作者对采自于澳大利亚和斯洛文尼亚的稻绿蝽的雄性、雌性外生殖器及触角节上的感觉毛进行了解剖比较和扫描电子显微镜下的观察研究 ,旨在从外生殖器及触角感觉器等方面找出支持该观点的证据 .研究证明 ,上述几种器官的微细结构在两个种群间并无显著的差异 ,不存在将二者分为姊妹种的依据 .故两个群体间生殖隔离现象与外生殖器的结构无关 . 相似文献
63.
Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma 总被引:35,自引:0,他引:35
Burkitt's-type lymphomas-leukaemias (BL) are monoclonal proliferations of malignant B lymphocytes. Irrespective of whether they carry the Epstein-Barr virus (EBV) genome, these tumour cells have been shown consistently to have one of the specific reciprocal chromosome translocations, t(8; 14), t(2; 8) or t(8; 22), involving the long arm of chromosome 8 (on 8q24) and chromosome 14, 2 or 22 (on 14q32, 2p12 and 22q11, respectively). The latter chromosomes have been shown recently to carry genes for immunoglobulin (Ig) heavy chains, and kappa and lambda light chains, respectively. Furthermore, the localization of kappa light chains within 2pcen-2p13 encompasses the breakpoint observed in Burkitt's translocation (2p12). It was therefore considered of interest to determine whether the expression of immunoglobulin chains in BL cells is related to the type of chromosomal anomalies observed. We report here that there is a direct relationship between expression of immunoglobulin light chains and specific type of translocation: BL cells with t(8; 22) express lambda chains, whereas those with t(2; 8) express kappa chains. 相似文献
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65.
Decisions on ass et allocations are often determined by covariance estimates from historical market data. In this paper, we introduce a wavelet-based portfolio algorithm, distinguishing between newly embedded news and long-run information that has already been fully absorbed by the market. Exploiting the wavelet decomposition into short- and long-run covariance regimes, we introduce an approach to focus on particular covariance components. Using generated data, we demonstrate that short-run covariance regimes comprise the relevant information for periodical portfolio management. In an empirical application to US stocks and other international markets for weekly, monthly, quarterly, and yearly holding periods (and rebalancing), we present evidence that the application of wavelet-based covariance estimates from short-run information outperforms portfolio allocations that are based on covariance estimates from historical data. 相似文献
66.
Aloysius Domingo David Amar Karen Grütz Lillian V. Lee Raymond Rosales Norbert Brüggemann Roland Dominic Jamora Eva Cutiongco-dela Paz Arndt Rolfs Dirk Dressler Uwe Walter Dimitri Krainc Katja Lohmann Ron Shamir Christine Klein Ana Westenberger 《Cellular and molecular life sciences : CMLS》2016,73(16):3205-3215
67.
68.
P Walter 《Experientia》1991,47(2):178-181
Some recent evidence on the benefits and hazards of elevated dosages of vitamins is summarized. Special emphasis is given on the safety of vitamins A, D, K1 and B6. Furthermore, the possibly beneficial effects of vitamins for athletic performance as well as the preventive potential of antioxidative vitamins and of carotenoids against cancer are discussed. 相似文献
69.
70.
E. G. Berger M. M. Weiser K. J. Isselbacher 《Cellular and molecular life sciences : CMLS》1976,32(6):690-691
Summary Agarose derivatized withp-nitrophenyl-N-acetyl--d-glucosamine was used for affinity chromatography for soluble galactosyltransferase from various sources. Moreover, this adsorbant acts as an acceptor for galactose when incubated with prepurified galactosyltransferase.This work was supported by a grant from the USPHS (grant No. 1 PO1 CA 14294-2). 相似文献