全文获取类型
收费全文 | 291篇 |
免费 | 0篇 |
专业分类
系统科学 | 10篇 |
理论与方法论 | 1篇 |
现状及发展 | 77篇 |
研究方法 | 23篇 |
综合类 | 166篇 |
自然研究 | 14篇 |
出版年
2022年 | 1篇 |
2018年 | 4篇 |
2016年 | 1篇 |
2014年 | 2篇 |
2013年 | 3篇 |
2012年 | 6篇 |
2011年 | 29篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2008年 | 11篇 |
2007年 | 12篇 |
2006年 | 9篇 |
2005年 | 11篇 |
2004年 | 7篇 |
2003年 | 13篇 |
2002年 | 13篇 |
2001年 | 13篇 |
2000年 | 13篇 |
1999年 | 7篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 7篇 |
1982年 | 1篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1976年 | 10篇 |
1975年 | 7篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 9篇 |
1970年 | 9篇 |
1969年 | 2篇 |
1968年 | 5篇 |
1967年 | 6篇 |
1966年 | 6篇 |
1965年 | 3篇 |
1963年 | 1篇 |
1948年 | 1篇 |
排序方式: 共有291条查询结果,搜索用时 531 毫秒
41.
Effect of thiocyanate on nitrosation of amines 总被引:2,自引:0,他引:2
42.
Clayton DG Walker NM Smyth DJ Pask R Cooper JD Maier LM Smink LJ Lam AC Ovington NR Stevens HE Nutland S Howson JM Faham M Moorhead M Jones HB Falkowski M Hardenbol P Willis TD Todd JA 《Nature genetics》2005,37(11):1243-1246
The main problems in drawing causal inferences from epidemiological case-control studies are confounding by unmeasured extraneous factors, selection bias and differential misclassification of exposure. In genetics the first of these, in the form of population structure, has dominated recent debate. Population structure explained part of the significant +11.2% inflation of test statistics we observed in an analysis of 6,322 nonsynonymous SNPs in 816 cases of type 1 diabetes and 877 population-based controls from Great Britain. The remainder of the inflation resulted from differential bias in genotype scoring between case and control DNA samples, which originated from two laboratories, causing false-positive associations. To avoid excluding SNPs and losing valuable information, we extended the genomic control method by applying a variable downweighting to each SNP. 相似文献
43.
Sinkins SP Walker T Lynd AR Steven AR Makepeace BL Godfray HC Parkhill J 《Nature》2005,436(7048):257-260
Wolbachia is a common maternally inherited bacterial symbiont able to induce crossing sterilities known as cytoplasmic incompatibility (CI) in insects. Wolbachia-modified sperm are unable to complete fertilization of uninfected ova, but a rescue function allows infected eggs to develop normally. By providing a reproductive advantage to infected females, Wolbachia can rapidly invade uninfected populations, and this could provide a mechanism for driving transgenes through pest populations. CI can also occur between Wolbachia-infected populations and is usually associated with the presence of different Wolbachia strains. In the Culex pipiens mosquito group (including the filariasis vector C. quinquefasciatus) a very unusual degree of complexity of Wolbachia-induced crossing-types has been reported, with partial or complete CI that can be unidirectional or bidirectional, yet no Wolbachia strain variation was found. Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat-encoding genes associated with a prophage region, one of which is sex-specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue. 相似文献
44.
Summary Adenyl cyclase activity in isolated mouse liver cell membranes was stimulated two-fold by endotoxin. Furthermore, endotoxin inhibited epinephrine induction of adenyl cyclase activity, apparently through interruption of the phospholipid moiety of the enzyme complex. 相似文献
45.
46.
47.
48.
Effect of cyproheptadine on the octopamine-induced responses in the mammalian central nervous system
Summary Extracellular recordings have been made from rat thalamic neurones anaesthetized with urethane, 1.5–2 g/kg i.p. Iontophoretically applied octopamine excited certain thalamic neurones in the ventral basal complex while inhibiting others. Both effects were reversibly antagonized by iontophoretically applied cyproheptadine without affecting responses to noradrenaline and dopamine.Acknowledgment. We are grateful to Merck, Sharp and Dohme for a gift of cyproheptadine HCl. 相似文献
49.
De novo mutations revealed by whole-exome sequencing are strongly associated with autism 总被引:1,自引:0,他引:1
Sanders SJ Murtha MT Gupta AR Murdoch JD Raubeson MJ Willsey AJ Ercan-Sencicek AG DiLullo NM Parikshak NN Stein JL Walker MF Ober GT Teran NA Song Y El-Fishawy P Murtha RC Choi M Overton JD Bjornson RD Carriero NJ Meyer KA Bilguvar K Mane SM Sestan N Lifton RP Günel M Roeder K Geschwind DH Devlin B State MW 《Nature》2012,485(7397):237-241
Multiple studies have confirmed the contribution of rare de novo copy number variations to the risk for autism spectrum disorders. But whereas de novo single nucleotide variants have been identified in affected individuals, their contribution to risk has yet to be clarified. Specifically, the frequency and distribution of these mutations have not been well characterized in matched unaffected controls, and such data are vital to the interpretation of de novo coding mutations observed in probands. Here we show, using whole-exome sequencing of 928 individuals, including 200 phenotypically discordant sibling pairs, that highly disruptive (nonsense and splice-site) de novo mutations in brain-expressed genes are associated with autism spectrum disorders and carry large effects. On the basis of mutation rates in unaffected individuals, we demonstrate that multiple independent de novo single nucleotide variants in the same gene among unrelated probands reliably identifies risk alleles, providing a clear path forward for gene discovery. Among a total of 279 identified de novo coding mutations, there is a single instance in probands, and none in siblings, in which two independent nonsense variants disrupt the same gene, SCN2A (sodium channel, voltage-gated, type II, α subunit), a result that is highly unlikely by chance. 相似文献
50.