多用户多径环境下DOA估计算法研究

针对移动通信中多用户多径环境下的DOA估计问题，提出利用CARE算法求出各用户的空间循征矢量，进而利用基于对称阵列的改进MUSIC算法求出各用户对应多径信号DOA的联合算法，仿真结果表明：结合CARE算法，基于对称阵列的改进MUSIC算法能自动对多用户的DOA进行分组，并能对每个用户的多径相干信号进行DOA估计，不需要做平滑计算，不需要判断多径信号的个数，不增加计算量。     

The genome sequence of the rice blast fungus Magnaporthe grisea

Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.     

半导体物理

本书是一本教材，系统地介绍了半导体物理的理论知识。为了使学生能更好地理解和应用这些理论和概念，本书还对一些基于半导体的重要系统的原理进行了简单的解释。全书共分10章。第1章半导体简介，介绍了半导体的定义和重要性、半导体理论的基础和一维理想结晶固体的量子态；第2章理想半导体的量子态，重点介绍了三维半导体的量子态；第3章纯半导体的激发态和含杂质半导体的量子态；第4章均相半导体的统计学；第5章半导体中的迁移现象；第6章光效应；     

成本与变化性关系的灰色模型

在变化减少方案理论的基础上,对变化性二因素和制造系统成本的关系进行了研究,运用灰色系统理论,建立了成本与变化性关系的灰色模型;并应用某纺织机械厂浆纱机产品的成本与变化性关系对部分模型进行了验证．     

Preparation of composite tubular grafts for vascular repair via electrospinning

A novel type of composite vascular graft was developed via electrospinning in the present investigation.Collagen and chitosan were blended to form the inner and outer layer.Poly(1-lactide-co-caprolacto...     

大型钢管无溶剂环氧涂层自动涂装技术

介绍了大型钢管无溶剂环氧涂层自动涂装技术的系统组成、工艺流程、质量检验和涂层修补措施。大型钢管无溶剂环氧涂层自动涂装技术采用热固化技术、涂料加热技术,运用双组份喷涂设备喷涂无溶剂环氧涂料,漆膜均匀厚度偏差小,一次成膜厚、固化时间短,提高防腐涂层的整体防腐性能和生产率,降低工人的劳动强度。     

A loss-of-function RNA interference screen for molecular targets in cancer

The pursuit of novel therapeutic agents in cancer relies on the identification and validation of molecular targets. Hallmarks of cancer include self-sufficiency in growth signals and evasion from apoptosis; genes that regulate these processes may be optimal for therapeutic attack. Here we describe a loss-of-function screen for genes required for the proliferation and survival of cancer cells using an RNA interference library. We used a doxycycline-inducible retroviral vector for the expression of small hairpin RNAs (shRNAs) to construct a library targeting 2,500 human genes. We used retroviral pools from this library to infect cell lines representing two distinct molecular subgroups of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like DLBCL and germinal centre B-cell-like DLBCL. Each vector was engineered to contain a unique 60-base-pair 'bar code', allowing the abundance of an individual shRNA vector within a population of transduced cells to be measured using microarrays of the bar-code sequences. We observed that a subset of shRNA vectors was depleted from the transduced cells after three weeks in culture only if shRNA expression was induced. In activated B-cell-like DLBCL cells, but not germinal centre B-cell-like DLBCL cells, shRNAs targeting the NF-kappaB pathway were depleted, in keeping with the essential role of this pathway in the survival of activated B-cell-like DLBCL. This screen uncovered CARD11 as a key upstream signalling component responsible for the constitutive IkappaB kinase activity in activated B-cell-like DLBCL. The methodology that we describe can be used to establish a functional taxonomy of cancer and help reveal new classes of therapeutic targets distinct from known oncogenes.     

基于度信息的图像过渡区提取与分割

提出一种基于度信息的图像过渡区提取与分割算法．将一幅图像映射为带权无向图,权函数定义为节点之间的相似度,由于目标内部与背景内部的像素同质性好,相似度大,因此度值较大,而边缘像素的度值就小,由此提取过渡区并进行图像分割．实验结果表明,本方法能够稳定地提取过渡区,且处理速度明显优于原有的过渡区提取方法。     

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlying mechanisms remain poorly understood. Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its regulation to the nuclear receptor PPARγ (peroxisome proliferator activated receptor γ), which is the adipocyte master regulator and the target of the thiazolidinedione class of insulin sensitizing drugs. FGF1 is the prototype of the 22-member FGF family of proteins and has been implicated in a range of physiological processes, including development, wound healing and cardiovascular changes. Surprisingly, FGF1 knockout mice display no significant phenotype under standard laboratory conditions. We show that FGF1 is highly induced in adipose tissue in response to a high-fat diet and that mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with a high-fat diet. Further analysis of adipose depots in FGF1-deficient mice revealed multiple histopathologies in the vasculature network, an accentuated inflammatory response, aberrant adipocyte size distribution and ectopic expression of pancreatic lipases. On withdrawal of the high-fat diet, this inflamed adipose tissue fails to properly resolve, resulting in extensive fat necrosis. In terms of mechanisms, we show that adipose induction of FGF1 in the fed state is regulated by PPARγ acting through an evolutionarily conserved promoter proximal PPAR response element within the FGF1 gene. The discovery of a phenotype for the FGF1 knockout mouse establishes the PPARγ–FGF1 axis as critical for maintaining metabolic homeostasis and insulin sensitization.     

ELNF归约演算

ＥＬＮＦ演算是在ＬＮＦ演算的基础上扩充而成的函数／逻辑归约演算系统，扩充的主要工作包括逻辑变量、谓词名的引进。提出并描述了逻辑函子ＳＯＬＵＴＩＯＮ和ＰＲＯＶＥ及其归约规则．讨论了ＥＬＮＦ演算的基本概念。为表征ＨＯＲＮ子句提供了一种有效方式。