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211.
T. Matsuoka T. Nishizaki Y. Ikeuchi Y. Okada K. Sumino 《Cellular and molecular life sciences : CMLS》1997,53(3):233-236
Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety
of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons),
and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency
of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward
currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the
cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances
of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower
slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT2 receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope
conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the
outward and fast inward currents may be mediated respectively by the 5-HT2 receptor, which is coupled to a G-protein, and by the 5-HT3 receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT2 and 5-HT3 receptors.
Received 27 September 1996; received after revision 4 November 1996; accepted 7 November 1996 相似文献
212.
J. W. M. Lagerberg J. VanSteveninck T. M. A. R. Dubbelman 《Cellular and molecular life sciences : CMLS》1997,53(3):257-262
The fluorescent dye Merocyanine 540 (MC540) is often used as a probe to monitor the molecular packing of phospholipids in
the outer leaflet of biomembranes. In a previous study we showed that the increased staining of erythrocytes with a perturbed
membrane structure was mainly due to an increase in the fluorescence yield of cell-bound MC540, rather than to an increase
of the number of bound molecules. Erythrocytes and ghosts exposed to continuous fluxes of H2O2 exhibited pronounced lipid peroxidation. Further, red blood cells subjected to this form of oxidative stress also showed
increased staining with MC540. It appeared that this was caused by a strong increase in binding of MC540, together with a
slight red shift of the fluorescence emission maximum and a small increase in the fluorescence yield of bound MC540. The changed
MC540 binding characteristics were not observed when lipid peroxidation was suppressed by the presence of the antioxidant
BHT in the incubation medium. However, open ghosts exposed to H2O2 showed no increase of MC540 binding, excluding a direct involvement of lipid peroxidation. Measurement of fluorescence emission
spectra and gel filtration studies showed that MC540 can bind to H2O2-exposed hemoglobin. Experiments with erythrocytes lysed in hypotonic medium after exposure to H2O2 revealed that peroxidation of lipids with H2O2 induced a non-specific permeabilization of the plasma membrane to MC540, thereby allowing MC540 to bind to the oxidatively
denatured, more hydrophobic hemoglobin. These results indicate that conclusions about packing of phospholipids in the outer
leaflet of the membrane based on increased MC540-staining should be drawn with care.
Received 27 September 1996; received after revision 5 November 1996; accepted 27 November 1996 相似文献
213.
214.
Conclusion The optimum wavelength of Nd3+-doped double-clad fiber laser or amplifier made in China is near 830 nm. The efficiency of Nd3+-doped double-clad fiber devices pumped by 820-nm laser is low due to ESA. In order to increase the photochemical stability
of the outer cladding, the material of the outer cladding must be advanced. 相似文献
215.
216.
The non-steroidal ecdysone agonist RH-5849 (1,2-dibenzoyl-l-tert-butylhydrazine) was found to be an effective neurotoxicant on injection into the American bird grasshopper,Schistocerca americana (Drury). Treated grasshoppers became immediately hyperactive, followed by loss of coordination, paralysis and eventually death. We also discovered that this compound induced bilateral autotomy of the metathoracic legs during the early stages of intoxication. However, no evidence of ecdysonergic or morphogenetic activities was observed. Synergism studies with neurotoxins of known mode of action suggested that RH-5849 has a mechanism of action similar to that of 4-amino pyridine, which blocks potassium channels. 相似文献
217.
The maximum consumption of the larvae of the pest and vector mosquitoCulex quinquefasciatus by the predatory mosquitoCulex (Lutzia) raptor was studied at various instars of both the predator and the prey. The prey preferences of the predator when given lavae of different instars were also investigated. The IVth instar of the predator consumed the maximum number of Ist instar and the maximum biomass of IVth instar larvae of the prey. Instars I and II of the predator preferred the Ist of the prey; instars III and IV of the predator preferred instars II and III of the prey respectively.The predator consumed an average of 157.1 larvae during its whole larval period, when each instar of the predator was given its preferred instar of the prey. 相似文献
218.
DeLuca-Termini混合熵的合理性分析及其推广 总被引:1,自引:0,他引:1
对DeLuca和Termini提出的混合熵的合理性进行了分析并加以推广,对其性质作了详细证明。并指出,本文混合熵的表达式具有更明确的数学及物理含义。 相似文献
219.
设m>1,n,p,q,r,s均为正整数,R是一个具有单位元1的环.证明了:如果R中的任意x,y满足且R具有Q(m)性质,则R是一个交换环.此外,在适当的条件下确立了R的交换性. 相似文献
220.
用子波变换分析方法实时监测视觉诱发电位的潜伏期 总被引:1,自引:0,他引:1
诱发电位的实时监测在临床中有重要意义。本文提出利用多分辨率子波分析技术来实时监测视觉诱发电位的潜伏期。为克服随机噪声的影响,我们引入相邻响应的相关系数来修正所检测得的潜伏期的偏移,并应用前一次响应的波峰位置来决定当前的搜寻范围。实验表明,本方法能实时监测视觉诱发电位的潜伏期。 相似文献