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121.
Penkowa M Espejo C Martínez-Cáceres EM Montalban X Hidalgo J 《Cellular and molecular life sciences : CMLS》2003,60(1):185-197
Metallothioneins I+II (MT-I+II) are antioxidant, neuroprotective factors. We previously showed that MT-I+II deficiency during
experimental autoimmune encephalomyelitis (EAE) leads to increased disease incidence and clinical symptoms. Moreover, the
inflammatory response of macrophages and T cells, oxidative stress, and apoptotic cell death during EAE were increased by
MT-I+II deficiency. We now show for the first time that demyelination and axonal damage are significantly increased in MT-I+II
deficient mice during EAE. Furthermore, oligodendroglial regeneration, growth cone formation, and tissue repair including
expression of trophic factors were significantly reduced in MT-I+II-deficient mice during EAE. Accordingly, MT-I+II have protective
and regenerative roles in the brain.
Received 31 October 2002; received after revision 23 November 2002; accepted 26 November 2002
RID="*"
ID="*"Corresponding author. M. Penkowa and C. Espejo contributed equally to this paper. 相似文献
122.
Large Cretaceous sphenodontian from Patagonia provides insight into lepidosaur evolution in Gondwana
Sphenodontian reptiles successfully radiated during Triassic and Jurassic times, but were driven almost to extinction during the Cretaceous period. The sparse Early Cretaceous record of sphenodontians has been interpreted as reflecting the decline of the group in favour of lizards, their suspected ecological successors. However, recent discoveries in Late Cretaceous beds in Patagonia partially modify this interpretation. Numerous skeletons of a new sphenodontian, Priosphenodon avelasi gen. et sp. nov., were collected from a single locality in the Cenomanian-Turonian Candeleros Formation, where it is more abundant than any other tetrapod group recorded in the quarry (for example, Crocodyliformes, Serpentes, Dinosauria and Mammalia). Adult specimens of Priosphenodon reached one metre in length, larger than any previously known terrestrial sphenodontian. Here we propose, using available evidence, that sphenodontians were not a minor component of the Cretaceous terrestrial ecosystems of South America, and that their ecological replacement by squamates was delayed until the early Tertiary. The new discovery helps to bridge the considerable gap in the fossil record (around 120 million years) that separates the Early Cretaceous sphenodontians from their living relatives (Sphenodon). 相似文献
123.
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28 总被引:20,自引:0,他引:20
Taillon-Miller P Bauer-Sardiña I Saccone NL Putzel J Laitinen T Cao A Kere J Pilia G Rice JP Kwok PY 《Nature genetics》2000,25(3):324-328
Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in the human genome. Population genetic theory suggests that LD is determined by the age of the markers, population history, recombination rate, selection and genetic drift. Despite the uncertainties in determining the relative contributions of these factors, some groups have argued that LD is a simple function of distance between markers. Disease-gene mapping studies and a simulation study gave differing predictions on the degree of LD in isolated and general populations. In view of the discrepancies between theory and experimental observations, we constructed a high-density SNP map of the Xq25-Xq28 region and analysed the male genotypes and haplotypes across this region for LD in three populations. The populations included an outbred European sample (CEPH males) and isolated population samples from Finland and Sardinia. We found two extended regions of strong LD bracketed by regions with no evidence for LD in all three samples. Haplotype analysis showed a paucity of haplotypes in regions of strong LD. Our results suggest that, in this region of the X chromosome, LD is not a monotonic function of the distance between markers, but is more a property of the particular location in the human genome. 相似文献
124.
125.
Samuel Sarmiento Juan Manuel García-Manso Juan Manuel Martín-González Diana Vaamonde Javier Calderón Marzo Edir Da Silva-Grigoletto 《系统科学与复杂性》2013,26(1):104-116
The aim of this paper is to describe and analyse the behaviour of heart rate variability (HRV) during constant-load, high-intensity exercise using a time frequency analysis (Wavelet Transform). Eleven elite cyclists took part in the study (age: 18.6±3.0 years; VO2max: 4.88±0.61 litres·min?1). Initially, all subjects performed an incremental cycloergometer test to determine load power in a constant load-test (379.55±36.02 W; 89.0%). HRV declined dramatically from the start of testing (p <0.05). The behaviour of power spectral density within the LF band mirrored that of total energy, recording a significant decrease from the outset LF peaks fell rapidly thereafter, remaining stable until the end of the test. HF-VHF fell sharply in the first 20 to 30 seconds. The relative weighting (%) of HF-VHF was inverted with the onset of fatigue, [1.6% at the start, 7.1 (p <0.05) at the end of the first phase, and 43.1% (p <0.05) at the end of the test]. HF-VHFpeak displayed three phases: a moderate initial increase, followed by a slight fall, thereafter increasing to the end of the test. The LF/HF-VHF ratio increased at the start, later falling progressively until the end of the first phase and remaining around minimal values until the end of the test. 相似文献
126.
基于晶格格林函数和Landauer-Büttiker公式,研究了脱氧核糖核酸分子器件在不同电势降落下的电荷输运性质。界面处的电势降落可以导致负微分电导现象的出现,而且随着电势降落在脱氧核糖核酸分子上的比例的提高,这个效应更加明显。电势降落导致的分子轨道的局域化是产生负微分电导现象的关键因素。 相似文献
127.
128.
129.
The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. 总被引:1,自引:0,他引:1
C Rodríguez Esteban J Capdevila A N Economides J Pascual A Ortiz J C Izpisúa Belmonte 《Nature》1999,401(6750):243-251
In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo. 相似文献
130.
本文论述了经济可持续发展与科技发展的关系,认为平顶山市科技发展战略的模式包括优势技术战略和适用技术战略两个部分。 相似文献