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Dubois M Demé B Gulik-Krzywicki T Dedieu JC Vautrin C Désert S Perez E Zemb T 《Nature》2001,411(6838):672-675
Self-assembled structures having a regular hollow icosahedral form (such as those observed for proteins of virus capsids) can occur as a result of biomineralization processes, but are extremely rare in mineral crystallites. Compact icosahedra made from a boron oxide have been reported, but equivalent structures made of synthetic organic components such as surfactants have not hitherto been observed. It is, however, well known that lipids, as well as mixtures of anionic and cationic single chain surfactants, can readily form bilayers that can adopt a variety of distinct geometric forms: they can fold into soft vesicles or random bilayers (the so-called sponge phase) or form ordered stacks of flat or undulating membranes. Here we show that in salt-free mixtures of anionic and cationic surfactants, such bilayers can self-assemble into hollow aggregates with a regular icosahedral shape. These aggregates are stabilized by the presence of pores located at the vertices of the icosahedra. The resulting structures have a size of about one micrometre and mass of about 1010 daltons, making them larger than any known icosahedral protein assembly or virus capsid. We expect the combination of wall rigidity and holes at vertices of these icosahedral aggregates to be of practical value for controlled drug or DNA release. 相似文献
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All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-dependent K+, Ca2+ and Na+ channels were regarded as a unique development of eukaryotic cells, adapted to accomplish specialized electrical signalling, as exemplified in neurons. Here we present the functional characterization of a voltage-dependent K+ (K(V)) channel from a hyperthermophilic archaebacterium from an oceanic thermal vent. This channel possesses all the functional attributes of classical neuronal K(V) channels. The conservation of function reflects structural conservation in the voltage sensor as revealed by specific, high-affinity interactions with tarantula venom toxins, which evolved to inhibit eukaryotic K(V) channels. 相似文献
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Marine iguanas die from trace oil pollution 总被引:1,自引:0,他引:1
An oil tanker ran aground on the Galapagos island of San Cristóbal on 17 January 2001, spilling roughly three million litres of diesel and bunker oil. The slick started to spread westwards and was dispersed by strong currents, so only a few marine animals were killed immediately as a result. Here we draw on the long-term data sets gathered before the spill to show that a population of marine iguanas (Amblyrhychus cristatus) on Sante Fe island suffered a massive 62% mortality in the year after the accident, due to a small amount of residual oil contamination in the sea. Another population on the more remote island of Genovesa was unaffected. 相似文献
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C Paulin Y Charnay P M Dubois J A Chayvialle 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1980,291(2):257-260
Substance P (SP) immunoreactive structures were localized by immunofluorescence technique within the central nervous system of human fetuses (12, 15, 19 and 24 weeks old). Specificity of the anti-SP serum was established by immunocytology and radio-immunology. A wide distribution of SP positive structures (pericaryons and/or fibres) was found in brain, spinal cord and dorsal root ganglia. Mesencephalon, pons and dorsal horns of the spinal cord showed very intense fluorescence. The preliminary observations are the first report concerning SP ontogeny in the Human central nervous system. However, it was difficult to ascribe a significance to this neuropeptide during fetal life. 相似文献
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