圆柱齿轮传动目标函数优化设计

圆柱齿轮传动是机械传动中应用最为广泛的装置，以其为例建立了用料最小的目标函数的数学模型，并进行了优化设计。该优化模型和优化方案比常规优化更接近实际，而且设计方法简便，易掌握。     

连续波强激光传输的研究

进行了千瓦级连续波ＣＯ２强激光传输的实验研究，传输距离分别为５０ｍ，８０ｍ和１００ｍ，接收到的远场花样中衍射次极大出现了不连续分布。通过远场强度分布的数值模拟对实验结果进行了定性的解释。研究结果为进一步深入研究提供了有益的资料。     

解非线性抛物型方程的多层网格扰动迭代法

提出一种数值求解非线性抛物型方程初边值问题的多层网格扰动迭代法；该方法有效地结合了多层网格方法和扰动迭代方法，在固定的时间网格层上该方法有二阶敛速，渐近最优；整体计算量为Ｏ（ＭＮ＿ｔ），其中Ｍ是时间计算层数目，Ｎ＿ｔ是空间分划细网层节点变量个数；计算误差不传播，且解决了迭代初值的选择问题。     

一种RAID评价新方法

引入时间冗余度对冗余磁盘阵列（ＲＡＩＤ）并行存储系统的速度特性给予直观描述，分析讨论为提高可靠性而付出的冗余时间开销程度，探索和建立一种ＲＡＩＤ评价新方法。这种方法以解析表达式给出时间冗余度与阵列结构特性参数间的关系，一方面可用作估计系统的带宽、比较不同系统的速度特性；另一方面可用以指导系统的优化设计。     

醇对SDS-CTAB-H2O体系双水相性质的影响

研究了短链一元醇(乙醇、正丁醇)和二元醇(乙二醇、1,4—丁二醇)对正负离子表面活性剂混合溶液(十二烷基硫酸钠—十六烷基三甲基溴化铵—水)双水相的影响。结果表明：一元醇的加入不但缩短了双水相的成相时间、使原水溶液双水相的区域得到扩展而且还会导致新双水相区域的出现,这种影响随着醇类链长的增长而增大。而二元醇的加入对双水相的相图影响不大,只是对形成双水相的表面活性剂最低总浓度稍有影响。实验结果也表明,出现双水相的表面活性剂最低总浓度与混合溶液的临界胶束浓度(CMC)有关,但CMC并不是决定出现双水相表面活性剂最低浓度的唯一因素。     

单角煤粉燃烧炉中煤粉着火与稳燃的数值模拟

在自行建立的数学模型基础上，对单角煤粉燃烧炉中煤粉着火与火焰稳定性进行了详尽的数值模拟。给出了直流式燃烧器、钝体燃烧铭及开缝钝体燃烧器的数值模拟结果，得到了与实验一致的结论，还针对直流式燃烧器考察了影响煤粉着火与火焰稳定性的各个因素。     

基于LARPBS模型的快速并行归并排序算法

提出了一种基于LARPBS模型上的并行归并排序算法,该算法使用M1 ε(0<ε<1)个处理器可以在O(lb lbM)时间内对Mε个有序序列进行归并.利用该归并算法对长度为N的序列进行排序,使用N1 ε个处理器可以在O((lb lb N)2)时间内完成.     

The joining of ribosomal subunits in eukaryotes requires eIF5B

Initiation of eukaryotic protein synthesis begins with the ribosome separated into its 40S and 60S subunits. The 40S subunit first binds eukaryotic initiation factor (eIF) 3 and an eIF2-GTP-initiator transfer RNA ternary complex. The resulting complex requires eIF1, eIF1A, eIF4A, eIF4B and eIF4F to bind to a messenger RNA and to scan to the initiation codon. eIF5 stimulates hydrolysis of eIF2-bound GTP and eIF2 is released from the 48S complex formed at the initiation codon before it is joined by a 60S subunit to form an active 80S ribosome. Here we show that hydrolysis of eIF2-bound GTP induced by eIF5 in 48S complexes is necessary but not sufficient for the subunits to join. A second factor termed eIF5B (relative molecular mass 175,000) is essential for this process. It is a homologue of the prokaryotic initiation factor IF2 (re and, like it, mediates joining of subunits and has a ribosome-dependent GTPase activity that is essential for its function.     

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function mutations in tumour suppressor genes, results in cell deregulation that is frequently associated with enhanced cellular stress (for example, oxidative, replicative, metabolic and proteotoxic stress, and DNA damage). Adaptation to this stress phenotype is required for cancer cells to survive, and consequently cancer cells may become dependent upon non-oncogenes that do not ordinarily perform such a vital function in normal cells. Thus, targeting these non-oncogene dependencies in the context of a transformed genotype may result in a synthetic lethal interaction and the selective death of cancer cells. Here we used a cell-based small-molecule screening and quantitative proteomics approach that resulted in the unbiased identification of a small molecule that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Significant antitumour effects are observed in piperlongumine-treated mouse xenograft tumour models, with no apparent toxicity in normal mice. Moreover, piperlongumine potently inhibits the growth of spontaneously formed malignant breast tumours and their associated metastases in mice. Our results demonstrate the ability of a small molecule to induce apoptosis selectively in cells that have a cancer genotype, by targeting a non-oncogene co-dependency acquired through the expression of the cancer genotype in response to transformation-induced oxidative stress.