过程-路径-层次三维集成管理控制模型

根据企业战略管理的实际需求,研究多维集成化管理控制系统的结构模型及其运行机理.将企业管理理论和自动控制理论相结合,把管理控制问题归纳成4个维度、5种机制,并从这些方面入手研究我国企业管理控制所存在的实际问题,探讨解决这些问题的管理控制系统的结构模型及其控制机理.从管理层次、管理过程和控制路径3个维度构建了多层次全过程前馈一反馈管理控制系统.由理论和应用研究可知,企业只有建立和完善这种多维集成化管理控制系统,通过层层反馈和前馈、层层调节和保障,才能确保其战略规划的最终实现.     

Characterization of the heteroepitaxial growth of 3C-SiC on Si during low pressure chemical vapor deposition

3C-SiC heteroepitaxial layers were grown on Si substrates using a horizontal, hot-wall low pressure chemical vapor deposition system. The crystal quality, surface morphology and thickness uniformity of the layers were characterized by X-ray diffraction, atomic force microcopy and Fourier transform infrared spectroscopy, respectively. Growth of the epitaxial layer was determined to follow a three-dimensional island mode initially and then switch to a step-flow mode as the growth time increases. Barrier epithelia, especially airway epithelial cells, are persistently exposed to micro-organisms and environmental factors. To protect the host from these microbial challenges, many immune strategies have evolved. The airway epithelium participates in the critical innate immune response through the secretion of immune effectors such as mucin, antimicrobial peptides (AMP), and reactive oxygen species (ROS) to entrap or kill invading microbes. In addition, airway epithelial cells can act as mediators connecting innate and adaptive immunity by producing various cytokines and chemokines. Here, we present an overview of the role of mucosal immunity in airway epithelium, emphasizing the framework of bacterial and viral infections along with regulatory mechanisms of immune effectors in human cells and selected animal models. We also describe pathophysiological roles for immune effectors in human airway disease.     

TRIM24 links a non-canonical histone signature to breast cancer

Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD) and bromodomain (Bromo) regions. The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional unit for combinatorial recognition of unmodified H3K4 (that is, histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3 acetylated at lysine 23, H3K23ac) within the same histone tail. TRIM24 binds chromatin and oestrogen receptor to activate oestrogen-dependent genes associated with cellular proliferation and tumour development. Aberrant expression of TRIM24 negatively correlates with survival of breast cancer patients. The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis.     

基于核磁共振技术的黄土内部孔径分布对逾渗特性的影响

黄土的逾渗特性作为黄土渗流中比较特别的性质,它涉及到了黄土渗透性突变的特殊问题,其重要性是毋庸置疑的。研究黄土内部的孔径分布对逾渗特性的影响可以为工程中的某些渗流问题提供理论依据与实践价值,然而前人的研究往往忽视了这部分内容。基于此,本文展开了一组原状黄土和两组重塑黄土的试验研究:采用变水头试验分析黄土渗流过程中的逾渗现象,然后利用核磁共振技术对三组试样进行孔隙分布评价,最终分析孔径分布对于黄土逾渗特性的影响。试验结果表明:（1）原状黄土由于原生结构较好,孔隙大小的分布较重塑黄土更为集中,孔径集中在0.011~ 0.11 μm的中孔隙最多;重塑黄土由于丧失了结构性,部分土颗粒会产生黏聚,从而导致土体内的微孔与大孔的比原状黄土多。（2）由于原状黄土孔隙更为集中,内部孔隙更不容易透水,所以更容易达到临界状态从而使得渗透性发生逾渗,原状黄土的临界水头比相同干密度的重塑黄土更高。而重塑黄土则是干密度越大,孔隙率越低,孔隙越小,临界水头越高。试验利用方便快捷的核磁共振技术,首次分析了黄土内部孔径分布对黄土逾渗特性的影响,富有创新性,试验可靠性高,成果可为黄土重大工程的基础建设中的有关渗流问题提供建议。     

低比转速离心泵叶轮切割对隔舌部位性能影响的数值分析

对MH-47—100型低比转速离心泵在D1／D2〉0．9和0．8〈D1／D2〈0．9的情况下共进行了5次切割,通过数值模拟得到了切割之后离心泵的性能曲线,并对切割后的各性能曲线和切割后离心泵隔舌部分的外特性和内特性进行对比分析,结果表明：切割量应保持在10％之内;小流量下对叶轮外径切割后泵隔舌部位流动影响较大,大流量时影响较小．     

功能化氧化石墨烯的靶向肿瘤成像与光热治疗

整合素α_vβ₃是一种跨膜糖蛋白, 高表达于多种肿瘤细胞表面, 如人恶性胶质瘤(U87-MG). 它能够作为一类肿瘤标志物, 为肿瘤类型的诊断提供依据, 并为肿瘤治疗提供潜在作用靶点. 本文以人恶性胶质瘤细胞(U87-MG)为治疗模型, 利用靶向配体——整合素α_vβ₃单克隆抗体(integrin α_vβ₃ monoclonal antibody), 偶联新型纳米材料——氧化石墨烯(nano-graphene oxide, NGO), 构建成一种新型纳米探针(NGO-mAb-FITC)用于靶向成像及光热治疗. 这种纳米探针具有主动靶向功能, 可识别α_vβ₃阳性表达细胞U87-MG, 但不被α_vβ₃阴性表达的人乳腺癌细胞(MCF-7)摄取. 通过异硫氰酸荧光素(FITC)共价修饰靶向配体, 使纳米探针(NGO-mAb-FITC)获得对肿瘤细胞的靶向成像作用. 同时, 利用氧化石墨烯在808 nm近红外激光照射下的光热转化性能, 使得特异性摄取NGO-mAb-FITC纳米探针的肿瘤细胞内部产生过高热(hyperthermia), 从而诱导肿瘤细胞热损伤及细胞凋亡. 实验结果表明, NGO-mAb-FITC能有效识别靶细胞, 为肿瘤诊断提供依据, 而利用氧化石墨烯的高光热转换性能, 为肿瘤治疗提供新途径, 并有望成为一种有潜力的新型靶向光热转换探针而用于肿瘤的成像诊断与光热治疗.     

基于维护的产品使用可靠性评估及应用

在对定期维护条件下的产品进行可靠性分析时,由于现有性能退化处理方法没有考虑维修行为对产品性能信息的影响,导致处理结果无法准确反映工程需要。考虑维护对该类产品退化量的影响,利用复合Poisson过程对其退化过程进行了建模,并给出了模型参数的矩估计方法,进而给出了一种与定期维护条件下的产品退化过程更加相符的可靠性评估方法。通过进行仿真算例分析,验证了方法的可行性,并说明了方法对合理选取维修决策具有一定的应用价值。     

雷达海面目标识别技术研究进展

 针对雷达海面目标识别特征数据缺乏和识别算法推广能力差等问题,从雷达目标电磁散射特性和目标分类识别两方面总结了雷达海面目标识别技术的研究热点和发展趋势。围绕海面目标雷达特性,从电磁散射测量和建模两个方面综述了国内外研究现状;从低分辨雷达回波、高分辨距离像、高分辨雷达图像3方面综述了海面目标识别技术发展现状;介绍了雷达海面目标识别工程应用情况;最后展望了海面目标识别技术的发展趋势。     

Generalization of the linguistic aggregation operator and its application in decision making

A generalization of the linguistic aggregation functions (or operators) is presented by using generalized and quasiarithmetic means.Firstly,the linguistic weighted generalized mean (LWGM) and the linguistic generalized ordered weighted averaging (LGOWA) operator are introduced.These aggregation functions use linguistic information and generalized means in the weighted average (WA) and in the ordered weighted averaging (OWA) function.They are very useful for uncertain situations where the available information cannot be assessed with numerical values but it is possible to use linguistic assessments.These aggregation operators generalize a wide range of aggregation operators that use linguistic information such as the linguistic generalized mean (LGM),the linguistic OWA (LOWA) operator and the linguistic ordered weighted quadratic averaging (LOWQA) operator.We also introduce a further generalization by using quasi-arithmetic means instead of generalized means obtaining the quasi-LWA and the quasi-LOWA operator.Finally,we develop an application of the new approach where we analyze a decision making problem regarding the selection of strategies.     

红外热成像技术表征高聚物材料拉伸形变热效应的方法

用红外热成像技术可以表征高聚物材料拉伸形变过程的热效应特征.本文主要从测试装置的建立、红外热成像仪的镜头选择、材料发射率的确定及温度的采集方法等几个角度,介绍如何通过红外热成像仪提高测试高聚物材料形变热效应特征准确性的方法.