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11.
The continuous need for miniaturization and increase in device speed drives the electronics industry to explore new avenues of information processing. One possibility is to use electron spin to store, manipulate and carry information. All such 'spintronics' applications are faced with formidable challenges in finding fast and efficient ways to create, transport, detect, control and manipulate spin textures and currents. Here we show how most of these operations can be performed in a relatively simple manner in a hybrid system consisting of a superconducting film and a paramagnetic diluted magnetic semiconductor (DMS) quantum well. Our proposal is based on the observation that the inhomogeneous magnetic fields of the superconducting film create local spin and charge textures in the DMS quantum well, leading to a variety of effects such as Bloch oscillations and an unusual quantum Hall effect. We exploit recent progress in manipulating magnetic flux bundles (vortices) in superconductors and show how these can create, manipulate and control the spin textures in DMSs. 相似文献
12.
Lymphangiogenesis in development and human disease 总被引:1,自引:0,他引:1
The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases. 相似文献
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1. Introduction Recent advances in Information and Communication Technologies (ICT) have occurred in a number of areas includinginformation quality (Chutimaskul and Wangpipatwong 2004), strategy (Sha, Hung and Lin 2004) organization (Crowne 2004), technological change (Mitchell 2004), and utility1. Introduction Recent advances in Information and Communication Technologies (ICT) have occurred in a number of areas includinginformation quality (Chutimaskul and Wangpipatwong 2004), strateg… 相似文献
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Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy 总被引:7,自引:0,他引:7
Zsurka G Kraytsberg Y Kudina T Kornblum C Elger CE Khrapko K Kunz WS 《Nature genetics》2005,37(8):873-877
Experimental evidence for human mitochondrial DNA (mtDNA) recombination was recently obtained in an individual with paternal inheritance of mtDNA and in an in vitro cell culture system. Whether mtDNA recombination is a common event in humans remained to be determined. To detect mtDNA recombination in human skeletal muscle, we analyzed the distribution of alleles in individuals with multiple mtDNA heteroplasmy using single-cell PCR and allele-specific PCR. In all ten individuals who carried a heteroplasmic D-loop mutation and a distantly located tRNA point mutation or a large deletion, we observed a mixture of four allelic combinations (tetraplasmy), a hallmark of recombination. Twelve of 14 individuals with closely located heteroplasmic D-loop mutation pairs contained a mixture of only three types of mitochondrial genomes (triplasmy), consistent with the absence of recombination between adjacent markers. These findings indicate that mtDNA recombination is common in human skeletal muscle. 相似文献
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Günther FISCHER 《系统科学与系统工程学报(英文版)》2006,15(4):399-418
1. Introduction The world food economy is increasingly being driven by a shift of diets towards livestock products. In the developing countries, consumption of meat has been growing at 5-6 percent p.a., and that of milk and dairy products at 3.3-3.5 percent p.a. in the last few decades. Much of the growth is taking place in China (Huang and Zhang et al. 2003a, Huang and Liu 2003b, Keyzer and van Veen 2004, Ma and Huang et al. 2004, Simpson and Cheng et al.1994, USDA Economic Research Se… 相似文献
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Formation of a functional thymus initiated by a postnatal epithelial progenitor cell 总被引:1,自引:0,他引:1
The thymus is essential for the generation of self-tolerant effector and regulatory T cells. Intrathymic T-cell development requires an intact stromal microenvironment, of which thymic epithelial cells (TECs) constitute a major part. For instance, cell-autonomous genetic defects of forkhead box N1 (Foxn1) and autoimmune regulator (Aire) in thymic epithelial cells cause primary immunodeficiency and autoimmunity, respectively. During development, the thymic epithelial rudiment gives rise to two major compartments, the cortex and medulla. Cortical TECs positively select T cells, whereas medullary TECs are involved in negative selection of potentially autoreactive T cells. It has long been unclear whether these two morphologically and functionally distinct types of epithelial cells arise from a common bi-potent progenitor cell and whether such progenitors are still present in the postnatal period. Here, using in vivo cell lineage analysis in mice, we demonstrate the presence of a common progenitor of cortical and medullary TECs after birth. To probe the function of postnatal progenitors, a conditional mutant allele of Foxn1 was reverted to wild-type function in single epithelial cells in vivo. This led to the formation of small thymic lobules containing both cortical and medullary areas that supported normal thymopoiesis. Thus, single epithelial progenitor cells can give rise to a complete and functional thymic microenvironment, suggesting that cell-based therapies could be developed for thymus disorders. 相似文献
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Andrada Tatu Enrico Bertini Tobias Schreck Daniel Keim Sebastian Bremm Tatiana von Landesberger 《清华大学学报》2012,(4):419-428
Subspace clustering addresses an important problem in clustering multi-dimensional data.In sparse multi-dimensional data,many dimensions are irrelevant and obscure the cluster boundaries.Subspace clustering helps by mining the clusters present in only locally relevant subsets of dimensions.However,understanding the result of subspace clustering by analysts is not trivial.In addition to the grouping information,relevant sets of dimensions and overlaps between groups,both in terms of dimensions and records,need to be analyzed.We introduce a visual subspace cluster analysis system called ClustNails.It integrates several novel visualization techniques with various user interaction facilities to support navigating and interpreting the result of subspace clustering.We demonstrate the effectiveness of the proposed system by applying it to the analysis of real world data and comparing it with existing visual subspace cluster analysis systems. 相似文献
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Greenman C Stephens P Smith R Dalgliesh GL Hunter C Bignell G Davies H Teague J Butler A Stevens C Edkins S O'Meara S Vastrik I Schmidt EE Avis T Barthorpe S Bhamra G Buck G Choudhury B Clements J Cole J Dicks E Forbes S Gray K Halliday K Harrison R Hills K Hinton J Jenkinson A Jones D Menzies A Mironenko T Perry J Raine K Richardson D Shepherd R Small A Tofts C Varian J Webb T West S Widaa S Yates A Cahill DP Louis DN Goldstraw P Nicholson AG Brasseur F Looijenga L Weber BL Chiew YE DeFazio A 《Nature》2007,446(7132):153-158
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers. There was substantial variation in the number and pattern of mutations in individual cancers reflecting different exposures, DNA repair defects and cellular origins. Most somatic mutations are likely to be 'passengers' that do not contribute to oncogenesis. However, there was evidence for 'driver' mutations contributing to the development of the cancers studied in approximately 120 genes. Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated. 相似文献
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Yuri D. ZAKHAROV Olga P. SMYSHLYAEVA Yasunari SHIGETA Alexander M. POPOV Tatiana D. ZONOVA 《自然科学进展》2006,16(13):50-67
The aim of this paper is to reconstruct the Jurassic-Early Cretaceous climatic conditions using new isotopic data. Paleobotanical data indicate that a cooling occurred gradually just after Late Triassic, and a temperature minimum was reached in the Pliensbachian. This was followed by a climatic optimum in the early Toarcian, cooling in the late Toarcian and a second climatic optimum in the Oxfordian. Published isotopic thermometry data and our new results on isotopic composition of some Jurassic invertebrate shells from the Russian Platform, Poland, Germany and England generally confirm this pattern, and also indicate a third climatic optimum in the Middle Callovian. Middle-Late Mesozoic adult belemnites apparently lived during their spawning phase, in shallow waters similar to extant Nautilus. However, at least juvenile belemnoids, unlike ammonoids, engaged in significant short-term vertical migrations in the water column, reaching colder waters of the upper bathyal zone. 相似文献