Induced recovery of defective membrane expression of a CC chemokine receptor 5 mutant by phytohemagglutinin

CC chemokine receptor 5 (CCR5) is a member of the G-protein-coupled receptor superfamily. It plays an important role in macrophage tropic human immunodeficiency virus-1 entry and in some inflammatory reactions. CCR5-893(–) is a single-nucleotide deletion that results in complete truncation of the C tail of the gene product. We detected CCR5-893(–) in a sample of patients infected with non-tuberculosis mycobacteria and found that it was maintained heterozygously with a frequency of 2%. There is no association between this mutation and any immunodeficiency. Membrane expression of CCR5-893(–) was substantially reduced compared to the wild type, but this defective surface presentation recovered greatly recovered in the presence of 2 mg l-1 phytohemagglutinin (PHA). However, PHA inducement did not affect the total intracellular expression of CCR5-893(–) or wild-type CCR5. Thus we suggest there exist some PHA-induced factor(s) that could mediate the presentation of truncated CCR5.Received 23 July 2003; accepted 18 August 2003     

古耀州瓷着色元素的中子活化分析

运用中子活化分析(NAA)技术,测定耀州瓷釉中29种元素的质量含量,从中选取24种着色元素．通过对比分析,最后确定铁是耀州瓷的着色主元素,证明了考古界“耀州瓷以铁为着色主元素”的说法．     

Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation

We found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic (MRX) and syndromic (MRXS) forms of X-linked mental retardation (XLMR). Clinical features in affected males include mental retardation, microcephaly, short stature, spastic paraplegia and midline defects. PQBP1 has previously been implicated in the pathogenesis of polyglutamine expansion diseases. Our findings link this gene to XLMR and shed more light on the pathogenesis of this common disorder.     

Signal frequency based self－tuning fuzzy controller for semi－active suspension system

A new kind of fuzzy control scheme, based on the identification of the signal‘ s main frequency and the behavior of the ER damper, is proposed to control the semi-active suspension system. This method ad-justs the fuzzy controller to achieve the best isolation effect by analyzing the main frequency‘ s characters and inspecting the change of system parameters. The input of the fuzzy controller is the main frequency and the op-timal damping ratio is the output. Simulation results indicated that the proposed control method is very effec-tive in isolating the vibration.     

三相电路的虚拟分析

利用电路仿真软件PSPICE8.0中正弦稳态电路的数值输出功能虚拟三相电路的实验,解决了传统实验中设备笨重老旧、特别是安全性差,因而只能"忍痛割爱"的问题.解决了传统实验中负载单一、测量数据不全的问题.为更多的不易完成的传统实验开辟了一条新路.     

Web Services在大型旋转机械在线诊断系统中的应用

Web Services是实现信息发布的一种软件与通讯技术。提出了Web Services技术与设备故障诊断技术结合的全新思路,将设备的工艺流程、工艺参数、信号特征、故障推理诊断结论等通过软件与通讯的方式实现数据的动态交换和人机界面(HMI)的交互,供用户操作,从而形成网络化的系统信息发布。介绍了Web Services的基本原理和特点,结合国家“十五”计划“八六三”项目课题“网络化、智能化大型旋转机械在线诊断系统”,对在线诊断系统中信息发布的常见内容进行了归纳分类,描述如何采用DELPHI6 Web Services组件,实现网络化、智能化大型旋转机械在线诊断系统的信息发布、查询等功能。     

Fuzzy cluster analysis of the provenance of ancient Yaozhou porcelain body

The technique of neutron activation analysis (NAA) has been employed to measure the content of 29 kinds of elements in the sample of Yaozhou porcelain bodies,Then a fuzzy cluster analsis has been conducted to the NAA data and a diagram of the dynamic fuzzy cluster analysis has been achived,The results indicate that the batch of ancient Yaozhou porcelain bodies,which were of different overglaze color and were produced by different kilns during a period of over 800 years from the Tang Dynasty (618-907 A.D.) to the Yuan Dyansty(1271-1368 A.D.) ,has shared a stable and concentrated raw material source,Provenances of porcelain bodies from different times ,though having their specific independence ,enjoy a close relationship and are not far from one another,Provenances of porcelain bodies made during the Tang Dynasty and the Five Dynasties (907-960 A.D.)are found to be closer to one another,while those of the Song (960-1279A.D.) and the Jin Dynasty (1115-1234 A.D.)are comparatively concentrated in certain areas and are different from those of the Tang Dynasty .Both the tri-colored glazed pottery made in Yaozhou kilns during the Tang Dynasty and the Yaozhou porcelain bodies of the Tang period are from the same provenance.     

Ultraviolet photoluminescence of porous anodic alumina films

Photoluminescence (PL) properties of porous anodic alumina (PAA) films prepared by using electrochemical anodization technique in a mixed solution of oxalic and sulfuric acid have been investigated. The PAA films have an intensive ultraviolet PL emission around 350 nm, of which a possible PL mechanism has been proposed. It was found that the incorporated oxalic ions, which could transform into PL centers and exist in the PAA films, are responsible for this ultraviolet PL emission.     

Role of FGF-2／FGFR signaling pathway in cancer and its signification in breast cancer

Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.     

NMR study on self-assembled cage complex of hexamethylenetetramine and cucurbit[n]urils

Self-assembled complexes between cage com-pounds cucurbit[n = 5—8]urils and hexamethylenetetramine were studied by using NMR techniques. Experimental results reveal that hexamethylenetetramine can lid cucurbit[5]uril to forming self-assembled capsules in which nothing is encap-sulated yet; the cavity of the cucurbit[7]uril can accommo-date a hexamethylenetetramine molecule to form a self- assembled host-guest inclusion. Moreover, both the cavity interaction of the cucurbit[7]uril with hexamethylenetetra-mine稨Cl and the portal interaction of the dipole carbonyl of the cucurbit[7]uril with hexamethylenetetramine稨Cl lead to form self-assembled capsules in which the hexamethylene-tetramine稨Cl are encapsulated in the hexamethylenetetra-mine稨Cl lidded cucurbit[7]uril. Although the structures of the portal and cavity to cucurbit[5]uril are similar, there is no obvious interaction between decamethylcucurbit[5]uril and hexamethylenetetramine, and also between cucurbit [6]uril or cucurbit[8]uril and hexamethylenetetramine.