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931.
932.
933.
C. A. Grob T. Reichstein H. Rosenthal 《Cellular and molecular life sciences : CMLS》1945,1(8):275-276
Summary As previously reported the larvae ofTribolium confusum require two unknown factors obtainable from yeast apart from various vitamines of the B-group for normal growth. One of these possesses acidic properties. This factor could be fully replaced by a folic acid preparation of potency 4000 kindly placed at our disposal by Prof.R. J. Williams. This may be regarded as a possibility but not as a proof that folic acid is the reported factor.
C. A. Grob dankt der Haco-Gesellschaft AG., Gümligen, für die Unterstützung dieser Arbeit. 相似文献
C. A. Grob dankt der Haco-Gesellschaft AG., Gümligen, für die Unterstützung dieser Arbeit. 相似文献
934.
935.
936.
In the rabbit jejunum, the elevation of temperature within the range of 25-37 degrees C diminished the sensitivity to noradrenaline (NA) for both the relaxation and amplitude inhibition. The relaxation by NA was mainly mediated via adrenergic beta-receptors at 25, 30 or 37 degrees C. The amplitude inhibition was mediated via alpha-receptors at 37 degrees C, and both alpha- and beta-receptors at 30 or 25 degrees C. 相似文献
937.
The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 microliters drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea. 相似文献
938.
Mammalian pineal melatonin: a clock for all seasons 总被引:9,自引:0,他引:9
The central role of the pineal gland and its hormone melatonin (MEL) in mammalian photoperiodic responses is discussed in terms of: 1) evidence for the involvement of MEL in photoperiodism, 2) which feature of the MEL secretion profile might be most important for regulating photoperiodic responses, 3) evidence for the modulation of responses to changes in daylength based on previous photoperiod exposure (i.e., photoperiodic history) and 4) how the MEL signal might be processed at its target sites to elicit physiological responses. 相似文献
939.
S. R. Sanders-Sanchez D. Malsbury A. T. C. Tsin 《Cellular and molecular life sciences : CMLS》1990,46(5):499-500
Summary Retinal pigment epithelium (RPE) cells were collected from, bovine eyes using a new method. The cells were harvested by vortexing the RPE and underlying choroid in 0.05 M citrate phosphate buffer, pH 5. RPE cells recovered by this method were compared to a standard method by microscopic examination of cell integrity, estimation of total protein, and assay of 11-cis and all-trans retinyl ester hydrolase (REH) activities. Results suggest that this method collects RPE cells of good integrity and with a significantly higher protein yield than the conventional method. Additionally, a much higher retinyl ester hydrolase activity was noted. Therefore we propose that this procedure offers a new and convenient method in the collection of RPE proteins for certain purposes such as enzyme purification. 相似文献
940.
Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene 总被引:21,自引:0,他引:21
The fibrinolytic potential of the vasculature is modulated primarily by the availability and activity of plasminogen activators, which convert the zymogen plasminogen into the active fibrin-degrading enzyme plasmin. The activities of these key regulatory enzymes are directly neutralized by their primary endogenous inhibitor, plasminogen activator inhibitor-1 (PAI-1). Although some individuals with a tendency to develop thrombotic disorders exhibit elevated levels of PAI-1 in their plasma, the cause-and-effect relationship between increased PAI-1 and thrombosis is still unclear. Specifically, it is not known whether chronic depression of fibrinolytic activity results in the development of thrombosis. To address this question we developed transgenic mice in which the contribution of PAI-1 to thrombus formation could be evaluated. The results presented in this report indicate that elevated levels of PAI-1 contribute to the development of venous but not arterial occlusions. 相似文献