Combined effects of testosterone and estradiol on the ventral lobe of the rat postate in organ culture]

After organ culture without hormone, the epithelial gland cells of Rat veantral prostate undergo atrophic changes, whereas the interstitial stroma components tend to increase. Estradiol (1-1,000 nM),added to the culture medium, is ineffective. On the contrary, testosterone (1-100 nM) maintains epithelial cells and prevents the increase of interstitial stroma. When estradiol (1-1,000 nM) is combined with a physiological concentration of testosterone (1-4 nM), the epithelial cells are well maintained, but the inhibitory action of testosterone on the stroma is counteracted so that the glandular epithelium and the interstitial stroma are both stimulated. However, when testosterone is used at supraphysiological (10-100 nM) concentrations, estradiol is completely ineffective and the structure of the prostate is identical to the one given by the androgen alone.     

Specific anti-antibody in transplantation

Zusammenfassung Durch ein immunologisches Dreieck-System (Hund-Kaninchen-Hund) wurde ein Anti-Antikörper bei Hunden erzeugt und seine Wirkung in vitro und in vivo demonstriert. Die Anti-Antikörper-Methode bietet neue Möglichkeiten, dem Problem der Transplantat-Abstossung und der Therapie der Krankheiten immunologischen Ursprungs näherzukommen.

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This investigation was supported by Public Health Service grant No. CA 02624 and the Detroit General Hospital Research Corp. and Metropolitan Hospital Research grant NO. 208-12.     

Special forms of amitotic nuclear division in striated muscle and other insect tissues

Résumé On décrit quelques aspects morphologiques de l'appareil nucléaire des fibres musculaires striées des insectes. Le nom Polykaryonéma est proposé pour désigner les noyaux filamenteux géants qui par fragmentations successives produisent des chaÎnes de noyaux indépendants, placées dans le centre des fibres musculaires adultes. Ce phénomène offre un bon exemple de division nucléaire amitotique.