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121.
Viviana Volta Anne Beugnet Simone Gallo Laura Magri Daniela Brina Elisa Pesce Piera Calamita Francesca Sanvito Stefano Biffo 《Cellular and molecular life sciences : CMLS》2013,70(8):1439-1450
The receptor for activated C-kinase 1 (RACK1) is a conserved structural protein of 40S ribosomes. Strikingly, deletion of RACK1 in yeast homolog Asc1 is not lethal. Mammalian RACK1 also interacts with many nonribosomal proteins, hinting at several extraribosomal functions. A knockout mouse for RACK1 has not previously been described. We produced the first RACK1 mutant mouse, in which both alleles of RACK1 gene are defective in RACK1 expression (ΔF/ΔF), in a pure C57 Black/6 background. In a sample of 287 pups, we observed no ΔF/ΔF mice (72 expected). Dissection and genotyping of embryos at various stages showed that lethality occurs at gastrulation. Heterozygotes (ΔF/+) have skin pigmentation defects with a white belly spot and hypopigmented tail and paws. ΔF/+ have a transient growth deficit (shown by measuring pup size at P11). The pigmentation deficit is partly reverted by p53 deletion, whereas the lethality is not. ΔF/+ livers have mild accumulation of inactive 80S ribosomal subunits by polysomal profile analysis. In ΔF/+ fibroblasts, protein synthesis response to extracellular and pharmacological stimuli is reduced. These results highlight the role of RACK1 as a ribosomal protein converging signaling to the translational apparatus. 相似文献
122.
Cristina Lanni Stefano Govoni Adele Lucchelli Cinzia Boselli 《Cellular and molecular life sciences : CMLS》2009,66(18):2985-3008
Clinical depression is viewed as a physical and psychic disease process having a neuropathological basis, although a clear
understanding of its ethiopathology is still missing. The observation that depressive symptoms are influenced by pharmacological
manipulation of monoamines led to the hypothesis that depression results from reduced availability or functional deficiency
of monoaminergic transmitters in some cerebral regions. However, there are limitations to current monoamine theories related
to mood disorders. Recently, a growing body of experimental data has showed that other classes of endogenous compounds, such
as neuropeptides and amino acids, may play a significant role in the pathophysiology of affective disorders. With the development
of neuroscience, neuronal networks and intracellular pathways have been identified and characterized, describing the existence
of the interaction between monoamines and receptors in turn able to modulate the expression of intracellular proteins and
neurotrophic factors, suggesting that depression/antidepressants may be intermingled with neurogenesis/neurodegenerative processes. 相似文献
123.