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排序方式: 共有96条查询结果,搜索用时 31 毫秒
71.
A. Schurmann G. S. G. Spencer C. J. Berry 《Cellular and molecular life sciences : CMLS》1995,51(8):780-785
Female dwarf rats at different ages were treated with recombinant porcine GH or with a potent sheep anti-rat GH serum. Body weight and spleen weight increased with GH and decreased with anti-GH treatment (p<0.001). Neither GH nor anti-GH treatment resulted in a change in circulating WBCs, but GH decreased, while anti-GH increased, RBC counts (p<0.001). Similarly, GH treatment tended to decrease the ratio of CD4+:CD8+ T-cells while anti-GH increased (p<0.05) the ratio. Anti-GH treatment also enhanced the animals' ability to produce specific IgG in response to KLH injection. These results indicate that GH may have a physiological role in suppressing humoral immune function but may enhance cell-mediated immunity. 相似文献
72.
Quayshawn Spencer 《Studies in history and philosophy of science》2004,35(4):759-782
Newton’s Principia introduces four rules of reasoning for natural philosophy. Although useful, there is a concern about whether Newton’s rules guarantee truth. After redirecting the discussion from truth to validity, I show that these rules are valid insofar as they fulfill Goodman’s criteria for inductive rules and Newton’s own methodological program of experimental philosophy; provided that cross-checks are used prior to applications of rule 4 and immediately after applications of rule 2 the following activities are pursued: (1) research addressing observations that systematically deviate from theoretical idealizations and (2) applications of theory that safeguard ongoing research from proceeding down a garden path. 相似文献
73.
The modifying effects of oxytocin on stress-induced changes in post-mortem muscle glycolysis in pigs
G. S. G. Spencer L. J. Wilkins D. Lister 《Cellular and molecular life sciences : CMLS》1981,37(2):152-153
Summary The effect of ante-mortem i.m. administration of oxytocin on post-mortem muscle metabolism in Pietrain pigs was examined. Treatment with oxytocin significantly retarded post-mortem glycolysis and stopped the production of pale, soft, exudative meat. 相似文献
74.
75.
Genome-wide association studies (GWAS) search for associations between genetic variants and disease status, typically via logistic regression. Often there are covariates, such as sex or well-established major genetic factors, that are known to affect disease susceptibility and are independent of tested genotypes at the population level. We show theoretically and with data from recent GWAS on multiple sclerosis, psoriasis and ankylosing spondylitis that inclusion of known covariates can substantially reduce power for the identification of associated variants when the disease prevalence is lower than a few percent. Whether the inclusion of such covariates reduces or increases power to detect genetic effects depends on various factors, including the prevalence of the disease studied. When the disease is common (prevalence of >20%), the inclusion of covariates typically increases power, whereas, for rarer diseases, it can often decrease power to detect new genetic associations. 相似文献
76.
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium Strange A Capon F Spencer CC Knight J Weale ME Allen MH Barton A Band G Bellenguez C Bergboer JG Blackwell JM Bramon E Bumpstead SJ Casas JP Cork MJ Corvin A Deloukas P Dilthey A Duncanson A Edkins S Estivill X Fitzgerald O Freeman C Giardina E Gray E Hofer A Hüffmeier U Hunt SE Irvine AD Jankowski J Kirby B Langford C Lascorz J Leman J Leslie S Mallbris L Markus HS Mathew CG McLean WH McManus R 《Nature genetics》2010,42(11):985-990
To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10?? and two loci with a combined P < 5 × 10??). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10??). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis. 相似文献
77.
Spencer Weart 《Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics》2010,41(3):208-217
With the coming of digital computers in the 1950s, a small American team set out to model the weather, followed by attempts to represent the entire general circulation of the atmosphere. The work spread during the 1960s, and by the 1970s a few modelers had produced somewhat realistic looking models of the planet’s regional climate pattern. The work took on wider interest when modelers tried increasing the level of greenhouse gases, and invariably found serious global warming. Skeptics pointed to dubious technical features, but by the late 1990s these problems were largely resolved—thanks to enormous increases in computer power, the number and size of the closely interacting teams that now comprised the international modeling community, and the crucial availability of field experiments and satellite data to set against the models’ assumptions and outputs. By 2007 nearly all climate experts accepted that the climate simulations represented reality well enough to impel strong action to restrict gas emissions. 相似文献
78.
Evans DM Spencer CC Pointon JJ Su Z Harvey D Kochan G Oppermann U Opperman U Dilthey A Pirinen M Stone MA Appleton L Moutsianas L Moutsianis L Leslie S Wordsworth T Kenna TJ Karaderi T Thomas GP Ward MM Weisman MH Farrar C Bradbury LA Danoy P Inman RD Maksymowych W Gladman D Rahman P;Spondyloarthritis Research Consortium of Canada 《Nature genetics》2011,43(8):761-767
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides. 相似文献
79.
O'Donovan MC Craddock N Norton N Williams H Peirce T Moskvina V Nikolov I Hamshere M Carroll L Georgieva L Dwyer S Holmans P Marchini JL Spencer CC Howie B Leung HT Hartmann AM Möller HJ Morris DW Shi Y Feng G Hoffmann P Propping P Vasilescu C Maier W Rietschel M Zammit S Schumacher J Quinn EM Schulze TG Williams NM Giegling I Iwata N Ikeda M Darvasi A Shifman S He L Duan J Sanders AR Levinson DF Gejman PV Cichon S Nöthen MM Gill M Corvin A Rujescu D Kirov G Owen MJ Buccola NG Mowry BJ 《Nature genetics》2008,40(9):1053-1055
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)). 相似文献
80.
Arnaud F Varela M Spencer TE Palmarini M 《Cellular and molecular life sciences : CMLS》2008,65(21):3422-3432
Sheep betaretroviruses offer a unique model system to study the complex interaction between retroviruses and their host. Jaagsiekte
sheep retrovirus (JSRV) is a pathogenic exogenous retrovirus and the causative agent of ovine pulmonary adenocarcinoma. The
sheep genome contains at least 27 copies of endogenous retroviruses (enJSRVs) highly related to JSRV. enJSRVs have played
several roles in the evolution of the domestic sheep as they are able to block the JSRV replication cycle and play a critical
role in sheep conceptus development and placental morphogenesis. Available data strongly suggest that some dominant negative
enJSRV proviruses (i.e. able to block JSRV replication) have been positively selected during evolution. Interestingly, viruses
escaping the transdominant enJSRV loci have recently emerged (less than 200 years ago). Thus, endogenization of these retroviruses
may still be occurring today. Therefore, sheep provide an exciting and unique system to study retrovirus-host coevolution.
(Part of a Multi-author Review) 相似文献