建筑结构的主动隔震控制

建筑结构的主动控制和被动控制可以有效地减少地震荷载时结构的动力反应。被动隔震控制已被广泛应用于实际的结构控制。为了进一步降低结构震动,主动控制无疑是一种比较理想的方法,它对于提高结构抵抗外界激励不确定性的能力,直接减少输入的干扰,以及在震动发生时连续自动的调整结构动力特性方面均优于被动控制。通过试验对建筑结构主动隔震控制进行研究,试验在伊利诺伊大学香槟分校的智能实验室进行。试验模型是3层2跨的剪切型结构,设置在底层的3个伺服千斤顶提供不超过2%建筑自重的控制力,控制结构的面内运动(X方向,Y方向和XY平面内的转动)。试验结果表明该控制技术不仅可以有效的控制基础隔震层的位移,而且可以控制基底剪力在5%结构自重以内。     

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four signature somatic mutations in addition to numerous lower frequency genetic events of uncertain significance. Here we use Sleeping Beauty (SB) transposon-mediated insertional mutagenesis in a mouse model of pancreatic ductal preneoplasia to identify genes that cooperate with oncogenic Kras(G12D) to accelerate tumorigenesis and promote progression. Our screen revealed new candidate genes for PDA and confirmed the importance of many genes and pathways previously implicated in human PDA. The most commonly mutated gene was the X-linked deubiquitinase Usp9x, which was inactivated in over 50% of the tumours. Although previous work had attributed a pro-survival role to USP9X in human neoplasia, we found instead that loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis. Clinically, low USP9X protein and messenger RNA expression in PDA correlates with poor survival after surgery, and USP9X levels are inversely associated with metastatic burden in advanced disease. Furthermore, chromatin modulation with trichostatin A or 5-aza-2'-deoxycytidine elevates USP9X expression in human PDA cell lines, indicating a clinical approach for certain patients. The conditional deletion of Usp9x cooperated with Kras(G12D) to accelerate pancreatic tumorigenesis in mice, validating their genetic interaction. We propose that USP9X is a major tumour suppressor gene with prognostic and therapeutic relevance in PDA.     

Elastic fiber homeostasis requires lysyl oxidase-like 1 protein

Elastic fibers are components of the extracellular matrix and confer resilience. Once laid down, they are thought to remain stable, except in the uterine tract where cycles of active remodeling occur. Loss of elastic fibers underlies connective tissue aging and important diseases including emphysema. Failure to maintain elastic fibers is explained by a theory of antielastase-elastase imbalance, but little is known about the role of renewal. Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation. Distinct from the prototypic lysyl oxidase (LOX), LOXL1 localizes specifically to sites of elastogenesis and interacts with fibulin-5. Thus elastin polymer deposition is a crucial aspect of elastic fiber maintenance and is dependent on LOXL1, which serves both as a cross-linking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin.     

Shear heating as the origin of the plumes and heat flux on Enceladus

Enceladus, a small icy satellite of Saturn, has active plumes jetting from localized fractures ('tiger stripes') within an area of high heat flux near the south pole. The plume characteristics and local high heat flux have been ascribed either to the presence of liquid water within a few tens of metres of the surface, or the decomposition of clathrates. Neither model addresses how delivery of internal heat to the near-surface is sustained. Here we show that the most likely explanation for the heat and vapour production is shear heating by tidally driven lateral (strike-slip) fault motion with displacement of approximately 0.5 m over a tidal period. Vapour produced by this heating may escape as plumes through cracks reopened by the tidal stresses. The ice shell thickness needed to produce the observed heat flux is at least 5 km. The tidal displacements required imply a Love number of h2 > 0.01, suggesting that the ice shell is decoupled from the silicate interior by a subsurface ocean. We predict that the tiger-stripe regions with highest relative temperatures will be the lower-latitude branch of Damascus, Cairo around 60 degrees W longitude and Alexandria around 150 degrees W longitude.