表面活性剂对水溶性荧光聚合物PPESO_3荧光性质的影响

研究几种不同类型的表面活性剂对所合成的新型水溶性荧光聚合物PPESO3(聚[5,3-二(3-磺酰化丙氧基)-1,4-苯撑乙烯])的作用. 结果表明, 阴离子表面活性剂SDS可使PPESO3荧光发生猝灭; 中性表面活性剂使得聚合物的荧光显著增强; 阳离子表面活性剂一般情况下也会使聚合物荧光增强. 利用表面活性剂对荧光聚合物的荧光增强作用可使这类聚合物成为一种新型的具有高灵敏性的荧光化学传感器.     

电力工业大气污染治理技术开发 的反思与模式创新

通过回顾我国大气污染治理技术的发展历程以及对我国现有大气污染治理技术的现状分析,针对我国在大气污染治理技术开发模式中存在的瓶颈,提出了一种以全方位多尺度系统级数值仿真模拟技术为核心,以要点试验和工程回归为辅助手段的新型技术开发模式,并实际应用该模式实现了大型火电机组烟气脱硫脱硝技术的开发和大规模工程应用,实现了技术的短周期开发和快速成熟。     

“电气控制与可编程序控制器”重点课程建设实践与思考

讨论了两年来"电气控制与可编程序控制器"重点课程建设的有关情况,并结合课程建设实践与实际总结了课程教学特色.针对教学过程中存在的一些现实问题,提出了今后的工作方向.     

Szász-Durrmeyer算子在Orlicz空间中的加权逼近

在Orlicz空间LM中讨论了Szász-Durrmeyer算子的加权逼近,得到了逼近阶的Jackson型估计.     

一类中立型系统的指数稳定性分析

研究了一类中立型时滞系统的指数稳定性问题,首先将中立型系统转化为广义系统,然后利用Lyapunove-Krasovskii泛函以及LMI的方法得到一个系统指数稳定性的一个充分条件.文中最后的实例表明此种方法较其它方法相比具有较小的保守性.     

水库可持续发展指标体系研究

随着水资源的日趋紧张,评价水库现状,研究探讨水利的可持续发展问题,己成为人们关注的热点.以江苏省某水库为例,对其运行、管理及周围生态环境和社会经济发展状况进行调查,并对调查资料进行分析、归纳、总结;提出了由4个一级指标、13个二级指标、38个基层指标组成的一套适合该水库可持续发展的指标体系,并应用层次分析法对各指标进行分析,得到一个综合评价指标.该体系和分析方法为其他水库可持续发展研究提供了参考.     

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

Polarity is an essential feature of many cell types, including neurons that receive information from local inputs within their dendrites and propagate nerve impulses to distant targets through a single axon. It is generally believed that intrinsic structural differences between axons and dendrites dictate the polarized localization of axonal and dendritic proteins. However, whether extracellular cues also instruct this process in vivo has not been explored. Here we show that the axon guidance cue UNC-6/netrin and its receptor UNC-5 act throughout development to exclude synaptic vesicle and active zone proteins from the dendrite of the Caenorhabditis elegans motor neuron DA9, which is proximal to a source of UNC-6/netrin. In unc-6/netrin and unc-5 loss-of-function mutants, presynaptic components mislocalize to the DA9 dendrite. In addition, ectopically expressed UNC-6/netrin, acting through UNC-5, is sufficient to exclude endogenous synapses from adjacent subcellular domains within the DA9 axon. Furthermore, this anti-synaptogenic activity is interchangeable with that of LIN-44/Wnt despite being transduced through different receptors, suggesting that extracellular cues such as netrin and Wnts not only guide axon navigation but also regulate the polarized accumulation of presynaptic components through local exclusion.     

The complete genome of an individual by massively parallel DNA sequencing

The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of 'genomic medicine'. However, the formidable size of the diploid human genome, approximately 6 gigabases, has prevented the routine application of sequencing methods to deciphering complete individual human genomes. To realize the full potential of genomics for human health, this limitation must be overcome. Here we report the DNA sequence of a diploid genome of a single individual, James D. Watson, sequenced to 7.4-fold redundancy in two months using massively parallel sequencing in picolitre-size reaction vessels. This sequence was completed in two months at approximately one-hundredth of the cost of traditional capillary electrophoresis methods. Comparison of the sequence to the reference genome led to the identification of 3.3 million single nucleotide polymorphisms, of which 10,654 cause amino-acid substitution within the coding sequence. In addition, we accurately identified small-scale (2-40,000 base pair (bp)) insertion and deletion polymorphism as well as copy number variation resulting in the large-scale gain and loss of chromosomal segments ranging from 26,000 to 1.5 million base pairs. Overall, these results agree well with recent results of sequencing of a single individual by traditional methods. However, in addition to being faster and significantly less expensive, this sequencing technology avoids the arbitrary loss of genomic sequences inherent in random shotgun sequencing by bacterial cloning because it amplifies DNA in a cell-free system. As a result, we further demonstrate the acquisition of novel human sequence, including novel genes not previously identified by traditional genomic sequencing. This is the first genome sequenced by next-generation technologies. Therefore it is a pilot for the future challenges of 'personalized genome sequencing'.     

参数p(x)为分段线性函数时斯图谟刘维尔问题的格林函数及其定性性质

研究了当参数p(x)是区间[0,1]上的分段线性函数时,非线性斯图谟刘维尔方程边值问题的格林函数及其性质,并证明了相应边值问题解的积分公式.