Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

三维光盘存储系统中双光头同步控制的频域分析与辨识

详细介绍了双光头同步控制原理.对采集的伺服模块聚焦误差跟踪信号及共焦模块读写光头的聚焦线圈驱动信号进行了频域分析,并以此两路信号作为系统输入输出,分别对三种参数模型进行参数优化.根据3种模型的频率响应及阶跃响应,选择双光头同步控制过程的参数模型为[450]阶的ARX模型.实测曲线与模型仿真结果符合度(fit)为78.0259%.     

罗丹明B光纤酸度传感器的研究

本文采用静电吸附方法将罗丹明B固定在Nafion膜上,制成光纤酸度传感器,具有响应迅速,稳定性良好,干扰少的优点,可用于2～8M硫酸和盐酸的连续监测。     

匣母和余母在粤方言中的古今演变

以广州话和古劳话为代表，探讨了古匣母和余母在粤方言中的演变规律。匣母演变成半元音［ｊ］［ｗ］和辅音［ｘ］［ｆ］，余母演变成半元音［ｊ］［ｗ］和辅音［ｘ］。这种变化与发音时的气流有关：如气流强，匣母会变成［ｘ］［ｆ］，余母会变成［ｘ］；如气流弱，又受了介音［ｉ］［ｕ］的影响，匣母和余母都会变成半元音［ｊ］［ｗ］。     

单边双裂纹模型及其J积分的守恒性

针对某些工程结构特点,设计了单边双裂纹模型。然后先从理论上证明了其结构J积分的守恒性,再以焊接接头为例,通过体现焊接接头的几个特征参数,从力学和几何不均匀性两方面给予有限元方法数值实验证明,从而为工程结构中类似的缺陷评定奠定基础。     

关于田径运动的训练原则分类及其相关内涵探析

从田径运动训练的实践出发，采用文献资料法和归纳法，在广泛研究国内外田径运动训练专家有关田径训练的论述基础上，根据各原则的性质，按照由宏观抽象，到微观具体的思路，将其划分为田径运动的基本训练，专项训练和方法学3类训练原则加以探讨，并具体分析了各原则的内涵。     

Mbius群的离散性(英文)

利用一个固定的抛物型M bius变换作为检验性元素来检验扩充复平面上的非初等M bius群的离散性 ,文中给出的结果改进了由Jrgensen所建立的判别准则     

观察、实验与科学思维能力

观察、实验需要科学思维作指导，科学思维又可在观察、实验中得以训练与提升，在观察、实验教学中应贯彻科学思维训练的“三互”原则。     

轧机设备油液监测技术的应用

通过对轧机关键设备的润滑油进行定期跟踪监测 ,利用理化分析、光谱分析和铁谱分析等摩擦学分析手段 ,及时掌握油品的使用状况和设备的磨损情况 ,以实现对设备进行故障诊断和视情维修     

港澳特别行政区制度须列入宪法教学体系之中

随着香港、澳门的先后回归，宪法学的体系也应作相应的调整，香港、澳门特别行政区制度应作为单独的一章列入宪法学的体系。